2022 Drug Carriers in Medicine and Biology GRC/GRS

2022年医学和生物学药物载体GRC/GRS

• 批准号: 10378904
• 负责人: Suzie H. Pun
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-18 至 2022-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378904
• 关键词: Address; Area; Basic Science; Biodistribution; Biological; Biology; Blood - brain barrier anatomy; Blood Vessels; Cells; Chemistry; Clinic; Clinical; Communities; Development; Discipline; Disease; Drug Carriers; Drug Delivery Systems; Drug Design; Drug Formulations; Drug Kinetics; Engineering; Environment; Epithelial; Faculty; Future; Goals; Hour; Immune system; Industrialization; Industry; Institution; Knowledge; Laboratory Research; Learning; Lung; Mediating; Medical; Medicine; Modern Medicine; Molecular; Nature; Nucleic Acids; Oncology; Organic Chemistry; Pharmaceutical Preparations; Pharmacologic Substance; Physics; Physiological; Physiology; Postdoctoral Fellow; Proteins; Research; Research Personnel; Science; Seasons; Site; Solubility; Students; System; Therapeutic; Thinking; Time; Translations; Woman; Work; base; career; clinical application; design; diversity and inclusion; engineering design; extracellular; graduate student; innovation; insight; interdisciplinary approach; laboratory development; medical specialties; meetings; multidisciplinary; new technology; next generation; novel strategies; novel therapeutics; patient oriented; posters; skills; small molecule; success; symposium

Project Summary The delivery of small molecules, proteins and biologic drugs, nucleic acids, and other molecular therapies relies to the site of the disease-causing target within the body is highly dependent on the ability to manage solubility, stability, biodistribution, and pharmacokinetics of the drug. The Drug Carriers for Medicine and Biology Gordon Research Conference (GRC) and its accompanying Gordon Research Seminar (GRS) provide key platforms for discussion and dissemination of critical developments in the design of drug delivery systems to meet the many unique challenges of this field. Addressing these issues requires an interdisciplinary approach that engages researchers in basic biology and physiology, chemistry, and physics that inform design as well as engineering and clinical perspectives. The GRC provides a unique environment that successfully brings these groups together to discuss and debate fundamental questions about delivery and to share new innovations in the field. The specific aims of this GRC/GRS are: 1) to provide a forum for discussion of the key barriers to delivery and physiological understanding to inform carrier design, 2) to facilitate discussion of delivery systems in an intellectually and culturally diverse, multidisciplinary environment, with input from engineering, physiological, regulatory, and translational perspectives, 3) to enable presentation and discussion of new innovations and cutting-edge research in the drug delivery field, and 4) to create opportunities for young faculty and other early investigators in the field to present their work and to build critical relationships and partnerships for professional advancement. The subtitle for the 2022 GRC is Drug Carriers for Medicine and Biology: “Enabling new therapies through drug carrier design”. Areas of focus in the seminar include new materials for drug delivery, drug carriers in oncology, cell-mediated drug delivery, intracellular delivery of biologics, biological carriers, advances toward translation and carrier interactions with the immune system. The GRS that takes place prior to the GRC enables graduate students and postdoctoral associates to examine the field and address important questions from their own perspectives as early investigators who are thinking toward the future of the field. Speakers will be selected from among research trainees across a broad range of institutions and disciplines. The 2022 GRS theme, which is “Exploring size- based delivery strategies for biologics and novel drug cargos,” will provide a forum for discussion that connects ongoing laboratory research and the kinds of issues that might ultimately determine translational success. The GRS will also feature a plenary speaker who will provide a deep perspective on this question and discussion leaders chosen from among leaders in the field who can provide background and perspective during the discussions.

项目摘要 小分子、蛋白质和生物药物、核酸和其他分子疗法的递送依赖于 到体内致病靶点的位置高度依赖于控制溶解度的能力， 稳定性、生物分布和药物动力学。医药生物学药物载体 研究会议（GRC）及其配套的戈登研究研讨会（GRS）提供了关键的平台 供讨论和传播药物输送系统设计方面的关键发展， 这一领域的许多独特挑战。解决这些问题需要采取跨学科的办法， 从事基础生物学和生理学，化学和物理学的研究人员，为设计提供信息， 工程和临床前景。GRC提供了一个独特的环境，成功地将这些 小组一起讨论和辩论有关交付的基本问题，并分享新的创新， 外地本报告的具体目的是：1）提供一个讨论主要障碍的论坛 传递和生理的理解，以告知载体设计，2）以促进讨论 在知识和文化多样化的多学科环境中提供系统， 从工程学、生理学、调节学和翻译学的角度，3）使呈现 和讨论药物输送领域的新创新和前沿研究，以及4）创造 为年轻的教师和该领域的其他早期研究人员提供机会，介绍他们的工作， 建立重要的关系和伙伴关系，以促进专业发展。2022年GRC的副标题 是药物载体的医学和生物学：“通过药物载体设计实现新的疗法”。重点领域 在研讨会包括新材料的药物输送，药物载体在肿瘤学，细胞介导的药物输送， 生物制剂、生物载体的细胞内递送朝着翻译和载体与 免疫系统.在GRC之前进行的GRS使研究生和博士后能够 协会检查该领域，并从自己的角度解决重要的问题，尽早 研究人员正在思考该领域的未来。发言人将从研究人员中选出。 学员来自广泛的机构和学科。2022年GRS的主题是“探索规模- 基于生物制品和新型药物货物的交付策略”将提供一个讨论论坛， 正在进行的实验室研究以及可能最终决定转化成功的各种问题。的 GRS还将有一位全体发言人，他将就此问题和讨论提供深入的观点 从该领域的领导人中挑选出来的领导人，他们可以在会议期间提供背景和观点。 讨论。