2022 Drug Carriers in Medicine and Biology GRC/GRS

项目摘要 小分子、蛋白质和生物药物、核酸和其他分子疗法的交付依赖于 体内致病靶点的位置高度依赖于控制溶解度的能力， 药物的稳定性、生物分布和药代动力学。医学和生物学的药物载体 研究会议(GRC)及其伴随的戈登研究研讨会(GRS)提供了关键平台 讨论和传播药物输送系统设计方面的关键发展，以满足 这一领域的许多独特挑战。解决这些问题需要跨学科的方法， 让研究人员从事基础生物学和生理学、化学和物理学的研究，为设计提供信息以及 工程学和临床的观点。GRC提供了一个独特的环境，成功地将这些 小组一起讨论和辩论有关交付的基本问题，并分享 田野。GRC/GRS的具体目标是：1)提供讨论关键障碍的论坛 对分娩和生理的了解，以告知载体设计，2)便于讨论 在智力和文化多样化的多学科环境中的交付系统，有投入 从工程、生理、监管和翻译角度，3)实现演示 和讨论药物递送领域的新创新和前沿研究，以及4)创造 为该领域的年轻教员和其他早期研究人员提供机会介绍他们的工作并 建立重要的关系和伙伴关系，促进职业发展。2022年GRC的副标题 是医学和生物学的药物载体：“通过药物载体设计实现新的疗法”。重点领域 研讨会内容包括药物释放的新材料、肿瘤药物载体、细胞介导性药物释放、 生物制剂的细胞内递送，生物载体，朝着翻译和载体相互作用的方向发展 免疫系统。在GRC之前进行的GRS使研究生和博士后 让员工尽早从自己的角度审视该领域并解决重要问题 正在考虑该领域未来的调查人员。演讲者将从研究中选出 培训对象涉及广泛的机构和学科。2022年GRS的主题是“探索规模-- 基于生物制品和新型药物货物的递送策略“将提供一个讨论论坛，将 正在进行的实验室研究以及可能最终决定翻译成功的问题类型。这个 GRS还将有一位全体演讲者，他将就这一问题和讨论提供深入的观点 从该领域的领导者中选出能够提供背景和观点的领导人 讨论。

Project Summary The delivery of small molecules, proteins and biologic drugs, nucleic acids, and other molecular therapies relies to the site of the disease-causing target within the body is highly dependent on the ability to manage solubility, stability, biodistribution, and pharmacokinetics of the drug. The Drug Carriers for Medicine and Biology Gordon Research Conference (GRC) and its accompanying Gordon Research Seminar (GRS) provide key platforms for discussion and dissemination of critical developments in the design of drug delivery systems to meet the many unique challenges of this field. Addressing these issues requires an interdisciplinary approach that engages researchers in basic biology and physiology, chemistry, and physics that inform design as well as engineering and clinical perspectives. The GRC provides a unique environment that successfully brings these groups together to discuss and debate fundamental questions about delivery and to share new innovations in the field. The specific aims of this GRC/GRS are: 1) to provide a forum for discussion of the key barriers to delivery and physiological understanding to inform carrier design, 2) to facilitate discussion of delivery systems in an intellectually and culturally diverse, multidisciplinary environment, with input from engineering, physiological, regulatory, and translational perspectives, 3) to enable presentation and discussion of new innovations and cutting-edge research in the drug delivery field, and 4) to create opportunities for young faculty and other early investigators in the field to present their work and to build critical relationships and partnerships for professional advancement. The subtitle for the 2022 GRC is Drug Carriers for Medicine and Biology: “Enabling new therapies through drug carrier design”. Areas of focus in the seminar include new materials for drug delivery, drug carriers in oncology, cell-mediated drug delivery, intracellular delivery of biologics, biological carriers, advances toward translation and carrier interactions with the immune system. The GRS that takes place prior to the GRC enables graduate students and postdoctoral associates to examine the field and address important questions from their own perspectives as early investigators who are thinking toward the future of the field. Speakers will be selected from among research trainees across a broad range of institutions and disciplines. The 2022 GRS theme, which is “Exploring size- based delivery strategies for biologics and novel drug cargos,” will provide a forum for discussion that connects ongoing laboratory research and the kinds of issues that might ultimately determine translational success. The GRS will also feature a plenary speaker who will provide a deep perspective on this question and discussion leaders chosen from among leaders in the field who can provide background and perspective during the discussions.