MRI and X-ray catheter design and prototyping

在过去的一年里，我们继续开发与磁共振成像(MRI)兼容的可视设备，以执行计划在MRI下执行的腔内介入程序。 我们已经发明了一种新型的分段血管导丝，它有望克服以前设备的许多安全和机械缺陷。我们已经优化了设计，并开发了一个质量系统，以实现首次人体测试，我们也预计在即将到来的一年中进行测试。 我们与Bogazici大学和佐治亚理工学院合作开发微电子产品的新制造技术，以实现安全和显眼的MRI设备，特别是用于人类应用的针状天线。这些技术已经成功地产生了一种MRI可见标记，它不需要过大的设备，从而限制了微创治疗的性能。 我们已经在一种新型的光声磁共振导管传输线方面取得了进展，该传输线有望进一步提高磁共振导管的安全性。 我们已经发明了几种一流的介入设备，用于新的非手术治疗程序。这些设备包括基于心房导管的三尖瓣修复术、通过腔静脉进入主动脉以使没有良好选择的患者能够进行经导管主动脉瓣置换术、非手术进入左心房、新型血管引导鞘，以及无需手术的先天性心脏病解剖外搭桥术。其中许多包括新型医疗设备的发明和专利申请，例如用于经下腔静脉进入主动脉的特制闭合设备。 我们还与工业界合作，将我们的实验室发明转化为私营部门的病人护理。我们与一家大型导管公司签订了合作研发协议，与小型导管公司签订了共同开发一些设备的研究协议。我们还赞助了我们内部实验室的小企业创新研究合同，通过小企业将新的高风险技术带入临床测试。

During the past year we have continued our work developing magnetic resonance imaging (MRI) compatible and visible devices to perform endoluminal interventional procedures that are planned to perform under MRI. We have invented a novel segmented vascular guidewire that promises to overcome many of the safety and mechanical shortcomings of previous devices. We have optimized the design and developed a quality system to allow first-in-human testing, which we also expect in the upcoming year. We collaborate with Bogazici University and Georgia Institute of Technology to develop new manufacturing techniques for microminiature electronics to enable safe and conspicuous MRI devices, especially a needle antenna for human application. These techniques have succeeded in generating a MRI visible marker that does not require an oversized device that would limit performance in minimally-invasive therapies. We have made inroads towards a novel optoacoustical MRI catheter transmission line which promises further to enhance the safety of MRI catheters. We have invented several first-in-class interventional devices for novel therapeutic non-surgical procedures. These include devices for trans-atrial catheter-based tricuspid valve repair, transcaval access to the aorta to enable transcatheter aortic valve replacement in patients with no good options, non-surgical access to the left atrium, novel vascular introducer sheaths, and extra-anatomic bypass for congenital heart disease without surgery. Many of these include inventions and patent applications for novel medical devices, such as purpose-built closure devices for transcaval access to the aorta. We also work with industry to translate our laboratory inventions into the private sector for patient care. We have entered into collaborative research and development agreements with a large catheter company, research agreements with small catheter company to co-develop some devices. We also have sponsored Small Business Innovation Research contracts from our intramural laboratory to shepherd novel high-risk technology through small businesses into clinical testing.