Biological and mechanical therapies enabled by cardiovascular interventional MRI

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During the past year we have continued our work applying rapid MRI to guide simple and complex mechanical and biological interventions. We are developing clinical-grade catheter devices to recanalize chronic total occlusions of peripheral arteries. Other catheter devices also are under development for real-time MRI procedures in animals and for novel X-ray guided procedures. We are developing catheter-based mitral annuloplasty to treat functional mitral valve regurgitation. We have additional success in porcine models of ischemic cardiomyopathy mitral valve regurgitation. We continue to develop methods to combine or fuse prior MRI-derived regions of interest with real-time X-ray during preclinical and clinical catheter-based procedures. For example, our X-ray Fused with MRI (XFM) system enables a novel approach to non-surgical mitral valve repair. We also demonstrated XFM guided repair of membranous ventricular septal defect, a congenital heart disease usually requiring surgical repair. We continue to prepare for clinical testing of real-time MRI to treat human disease, including obstructive peripheral artery atherosclerosis.