MRI cardiovascular catheterization technology development

在过去的一年中，我们继续使用一种新型的低场和高性能的MRI系统在0.55 T的人体心血管MRI。该系统保留了SAR降低的成像，允许使用导电金属心血管导丝进行MRI导管插入术。这些允许使用基本的金属导管工具，而不会产生危险的加热。 与Adrienne Campbell-Washburn的实验室合作，我们正在帮助表征低场下感兴趣组织的基本MR特性。 我们研究了低场高性能MRI对铁敏感性标记物成像的价值，用于导丝跟踪和导航。 我们研究了低场高性能MRI对减轻磁流体动力学效应的影响，该效应可使人体研究受试者的ECG复极发生扭曲。 我们正在通过合作研发协议与行业密切合作，在介入MRI实验期间以及在X射线和MRI之间转移期间，安全监测和记录患者血流动力学的系统。 我们正在与业界密切合作，将我们的开发成果转化为可广泛用于世界各地医疗保健的商业工具。 具体而言，我们正在研究如何确保导电金属导管器械在实时MRI期间的安全性。

During the past year we continued human cardiovascular MRI using a novel low-field and high-performance MRI system at 0.55T. The system preserves imaging with reduced SAR which allows MRI catheterization using conductive metallic cardiovascular guidewires. These allow using fundamental metallic catheter tools without dangerous heating. In collaboration with the laboratory of Adrienne Campbell-Washburn we are helping to characterize fundamental MR properties of tissues of interest at low field. We have investigated the value of low-field high-performance MRI to image iron susceptibility markers for guidewire tracking and navigation. We have investigated the impact of low-field high-performance MRI to mitigate the magnetohydrodynamic effect that irrevocably distorts ECG repolarization, in human research subjects. We are working closely with industry, through a Collaborative Research and Development Agreement, system for safe patient hemodynamic monitoring and recording during interventional MRI experiments and during transfer between X-ray and MRI. We are working closely with industry to transfer our developments into commercial tools that can be used widely in medical care throughout the world. Specifically we are working on ways to assure safety of conductive metallic catheter devices during real-time MRI.