Pilot Project Program

这个应用程序的首要目标是继续发展和加强达特茅斯囊性纤维化 研究中心(DartCF)，在与NIDDK任务相关的领域复制我们之前成功的 慢性阻塞性肺疾病在呼吸道生物学和感染方面的研究轨迹。试点项目计划(P3)是一个完整的 这是我们战略的一部分。在我们P30资助的第一年，我们已经扩大了我们的调查能力 肠道中宿主-微生物的相互作用和肠道微生物失调对CF相关性糖尿病和整体的影响 这些患者的全身性疾病和健康。第一批试剂、出版物和拨款申请如下 从我们的首批试点项目中脱颖而出。反映出对以下方面日益增长的兴趣和核心支持 在这些研究领域，我们开放的RFA引出了18个与NIDDK相关的高质量提案。从这些方面，我们有 选择了一套新的四个P3项目，所有项目都与胃肠道、全身或肝脏方面的CF有关。我们的战略 建设我们目前的研究基地的优势直接来自于过去有效地使用试点资金 ~15年。利用我们通过试点增强研究能力的经验和出色记录 资金，P3计划将(1)鼓励开发初步数据以开启新的研究 机会，完善假设和实力建议，以竞争外部支持，(2)增强 协作和跨学科研究，以吸引达特茅斯大学的现有研究人员，包括那些拥有 记录CF研究和该领域的新手，并支持新招聘的教师，(3)深化我们的储备库 通过向内科科学家及其合作者提供资金来支持翻译和临床研究项目， (4)支持提交多名调查员的补助金；(5)通过以下方式支持专业发展 指导初级教员，包括基础科学家和内科科学家。这是一种行之有效的策略。在过去, 我们的CF基金会研究发展计划(RDP)和NIH生物医学研究中心 卓越(Cobre)奖将140万美元的试点资金转化为2290万美元的外部赠款支持 在过去的14年里。请注意，2018年的科布雷日落和CF飞行员与肺部话题有关 由RDP独家支持。以此模型为框架，我们设计了一个包容式 申请申请(RFA)和严格的多阶段审查程序，以授予P3补助金，以扩大我们的 研究肠道中宿主-微生物相互作用的能力以及肠道微生物失调对CF相关的影响 糖尿病，在三个机制下：(1)初级教员的基础或翻译指导奖，(2) 跨学科合作基础或翻译奖，以及(3)创新翻译或临床奖 由医学博士或医学博士/博士教研员领导的研究。所有这三个机制都促进了跨学科、多学科、多层次的 研究人员和临床相关研究。通过吸引现有和新的教职员工并支持 作为变革性的研究，P3将直接增强DartCF的认同度、影响力和研究基础。

The overarching goal of this application is to continue to develop and strengthen the Dartmouth Cystic Fibrosis Research Center (DartCF), reproducing in areas relevant to NIDDK mission our previous successful trajectory of CF-related research in airway biology and infection. The Pilot Project Program (P3) is an integral part of our strategy. In our first year of P30 funding, we have already expanded our capacity to investigate host-microbe interactions in the gut and the impact of gut dysbiosis on CF-related diabetes and overall systemic disease and health of these patients. The first reagents, publications and grant submissions are emerging from our inaugural set of pilot projects. As a reflection of the growing interest in and Core support for these research areas, our open RFA elicited 18 high-quality NIDDK-relevant proposals. From these, we have selected a new set of four P3 projects, all in areas related to GI, systemic or liver aspects of CF. Our strategy to build the current strengths of our research base stems directly from effective use of pilot funds over the past ~15 years. Using our experience and outstanding track record of enhancing research capacity through pilot funds, the P3 Program will (1) encourage development of preliminary data to open up new research opportunities, refine hypotheses, and strength proposals to compete for extramural support, (2) enhance collaborative and interdisciplinary research to engage current researchers at Dartmouth, including those with a record of CF research and those new to the field, and support newly recruited faculty, (3) deepen our reservoir of translational and clinical research projects by providing funds to physician-scientists and their collaborators, (4) nucleate the submission of multi-investigator grants, and (5) support professional development through mentoring of junior faculty, including both basic and physician scientists. This is a proven strategy. In the past, our CF Foundation Research Development Program (RDP) and NIH Center for Biomedical Research Excellence (COBRE) awards leveraged $1.4M of pilot funding into $22.9M dollars of extramural grant support over the past 14 years. Note that the COBRE sunset in 2018 and that CF pilots related to pulmonary topics are supported exclusively by the RDP. Using this model as a framework, we have designed an inclusive Request for Applications (RFA) and rigorous multi-stage review procedure to award P3 grants to expand our capabilities to investigate host-microbe interactions in the gut and the impact of gut dysbiosis on CF-related diabetes, under three mechanisms: (1) Mentored Basic or Translational Awards for junior faculty, (2) interdisciplinary Collaborative Basic or Translational Awards, and (3) Innovative Translational or Clinical Studies led by an MD or MD/PhD faculty investigator. All three mechanisms foster interdisciplinary, multi- investigator, and clinically relevant research. By engaging existing and new faculty and supporting transformative research, the P3 will directly enhance the identity, impact, and research base of DartCF.