Dartmouth Cystic Fibrosis Training Program

在本申请中，我们建议继续资助达特茅斯囊性纤维化培训计划 (DCFTP)。寻求持续的支持，以提供全面、高度互动的跨部门培训 课程的重点是基础知识和翻译科学。该计划的总体理念 是使用以疾病为中心的方法来教授基本概念和翻译 动态、多学科研究和基于团队的指导背景下的科学 环境。在本意见书中，我们建议每年直接资助4名学员。我们的节目已经汇集了 来自不同部门的22名敬业培训师的才华-我们目前的计划 包括生物化学和细胞生物学、化学、分子系统系的教员 生物学、医学、微生物学/免疫学、流行病学、儿科学和工程学-提供 向博士生和医学博士/博士生讲授与CF相关的研究。DCFTP将在 已有丰富的基础研究、翻译研究和临床相关研究的研究基地。流程图研究 达特茅斯的项目已经从1997年的三名研究人员和一名NIH拨款发展到一个 世界级科学家，目前每年可获得2,110万美元的研究经费直接成本(平均为0.96万美元 调查员平均)。达特茅斯还将提供约3960万美元的机构支持，包括直接支持 到DartCF，我们的培训项目和附属的研究生项目，在未来5年。我们的培训 教师使用的方法包括临床队列研究、定量方法和 基于实验室和动物的研究；因此，我们的受训人员接触到了广泛的科学研究 回答有影响力的科学问题的策略。DCFTP参与培训学院，它 包括博士、医学博士和医学博士/博士研究人员，在一系列学科中工作，以CF研究为中心 专注；所有培训学院都进行研究，资金充足，并教授和指导我们的受训人员。这 一组基础和医生-科学家研究人员积极从事与CF相关的研究， 细胞生物学、结构生物学、微生物学、免疫学、微生物组、遗传学、生物信息学、 统计学和蛋白质组学。我们计划的一个特点是我们培训的密切和一致的互动 通过DCFTP赞助的一般和学员特定活动与我们的DCFTP实习生进行交流，包括 每周的研究会议、课程、杂志俱乐部和我们的年度静修。培训-赠款资金和DCFTP- 受赞助的、学员特定的增强活动提供了一个统一的基础，极大地促进了 这一群体的互动性(过去~5年中的38份合作出版物证明了这一点 我们的22个培训学院和9个附属学院)以及这些教师所持有的合作助学金。

In this application, we propose continued funding to the Dartmouth Cystic Fibrosis Training Program (DCFTP). Continuing support is sought for a comprehensive, highly interactive, interdepartmental training program with an emphasis on CF basic and translational science. The overall philosophy of the program is to use a disease-centered approach to teach fundamental concepts of basic and translational science in the context of a dynamic, multidisciplinary research and team-based mentoring environment. In this submission, we propose to directly fund 4 Trainees annually. Our program has pooled the talents of 22 dedicated Faculty Trainers from a wide range of departments—our current program includes faculty in the departments of Biochemistry and Cell Biology, Chemistry, Molecular Systems Biology, Medicine, Microbiology/ Immunology, Epidemiology, Pediatrics, and Engineering—to provide instruction in CF-related research to PhD and MD/PhD students. The DCFTP will function in the context of a Research Base already rich in basic, translational, and clinical CF-related studies. The CF research program at Dartmouth has grown from three investigators and one NIH grant in 1997 to a community of world-class scientists that currently secure $21.1M per year in direct costs of research funding ($0.96M per investigator average). Dartmouth will also provide ~$39.6M in institutional support, including direct support to DartCF, our training program and the affiliated graduate programs, over the next 5 years. Our Training Faculty use approaches including the study of clinical cohorts, quantitative methods, and laboratory-based and animal studies; thus, our trainees are exposed to a broad range of scientific strategies to answer impactful scientific questions. The DCFTP participating Training Faculty, which include PhD, MD, and MD/PhD researchers, work in a range of disciplines, with CF research as the central focus; all Training Faculty conduct research, are well funded, and teach and mentor our Trainees. This group of basic and physician-scientist researchers is actively engaged in CF-related research, with expertise in cell biology, structural biology, microbiology, immunology, microbiome, genetics, bioinformatics, statistics, and proteomics. A hallmark of our program is the close and consistent interaction of our Training Faculty with our DCFTP Trainees via DCFTP-sponsored general and Trainee-specific activities, including weekly research meetings, courses, journal clubs, and our annual retreat. Training-grant funds and DCFTP- sponsored, Trainee-specific enhanced activities provide a unifying base that greatly facilitates the strikingly interactive nature of this group (evidenced by 38 collaborative publications over the past ~5 years among our 22 Training and 9 Affiliated Faculty) and of the collaborative grants held by these faculty.