Mapping human brain perivascular space in lifespan using human connectome project data

使用人类连接组项目数据绘制生命周期中的人脑血管周围空间

• 批准号: 10012731
• 负责人: Jeiran Choupan
• 金额: $ 133.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10012731
• 关键词: 3-Dimensional; Adolescent; Affect; Age; Aging; Anisotropy; BRAIN initiative; Biological; Blood Pressure; Body mass index; Brain; Brain region; Caliber; Cerebrospinal Fluid; Cognition; Cognitive; Communities; Computational Technique; Data; Data Analyses; Data Set; Deposition; Development; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Drug Delivery Systems; Early Diagnosis; Foundations; Future; Gatekeeping; Goals; Health; Heterogeneity; Human; Image; Immune system; Individual Differences; Intercellular Fluid; Knowledge; Life; Life Style; Light; Liquid substance; Longevity; Lymphatic; Machine Learning; Magnetic Resonance Imaging; Maps; Measures; Modeling; Morphology; National Institute of Mental Health; Neuroglia; Neurologic; Outcome; Participant; Pathologic; Pathway interactions; Pediatric cohort; Performance; Physiology; Process; Property; Public Health; Research; Research Personnel; Resolution; Resources; Robin bird; Role; Sample Size; Sampling; Short-Term Memory; Sleep; Smoking; Statistical Data Interpretation; Structure; System; T2 weighted imaging; Techniques; Testing; Tissues; Tobacco use; Variant; Visual; Walking; Work; age related; base; biophysical properties; brain health; cardiovascular health; cognitive development; cognitive function; cognitive performance; cohort; connectome; data archive; glymphatic system; human imaging; in vivo; innovation; insight; interest; lifestyle factors; neurobehavioral; neurodevelopment; neuroimaging; neurovascular unit; novel; sex; sleep quality; tool; wasting

PROJECT SUMMARY Perivascular spaces are a critical component of the glia-lymphatic circuit, facilitating the clearance of soluble waste. The role of perivascular spaces and changes in the brain’s clearance system in normal development, aging, and cognition is not fully understood, mainly due to lack of neuroimaging capabilities. However, noninvasive in vivo mapping of the perivascular space fluid with high accuracy and reliability is now made possible with our recent analytical developments, using human connectome project (HCP) data. The objective of this project is to map structural and diffusion features of perivascular space fluid across lifespan. PVS features include PVS presence (e.g., count and volume fraction) and diffusion (e.g., diffusivity and anisotropy). These features will be extracted regionally and globally across the brain. Structural MRI will provide information regarding localization and extent of the PVS and diffusion MRI will be used to investigate biophysical properties of the PVS fluid and surrounding tissue. The central hypothesis is that the perivascular space fluid increases across lifespan. We also hypothesize that individual differences exist in perivascular spaces as a function of demographic, general health and lifestyle health choices, such as body mass index, blood pressure, tobacco use and sleep quality. The central hypothesis will be tested by characterizing the normative map of the perivascular space fluid across the lifespan and in relation to various demographic, cognitive measures, and health factors. We will also examine whether subjects neuro-behavioral performances can be predicted by perivascular space features. We will pursue these aims by applying innovative MRI-based computational techniques that we recently developed and optimized on HCP data. We will also use Adolescent Brain Cognitive Development (ABCD) Studies to build first normative template of PVS in neurodevelopment. Together, our findings will ultimately allow for a better understanding of the human brain clearance system, and our shared perivascular space mapping workflow can provide a resource for researchers to study a wide range of neurological conditions.

项目摘要 血管周围间隙是胶质-淋巴回路的关键组成部分，促进可溶性 浪费血管周围空间的作用和大脑清除系统在正常发育中的变化， 衰老和认知尚未完全理解，主要是由于缺乏神经成像能力。然而，在这方面， 现在可以进行具有高精度和可靠性的血管周围空间流体的非侵入性体内标测 可能与我们最近的分析发展，使用人类连接体计划（HCP）的数据。客观 该项目的目的是绘制整个生命周期中血管周围空间流体的结构和扩散特征。PVS功能 包括PVS存在（例如，计数和体积分数）和扩散（例如，扩散性和各向异性）。这些 特征将在大脑中区域性和全局性地提取。结构MRI将提供信息 关于PVS的定位和范围，将使用弥散MRI研究生物物理特性 和周围组织的残留物中心假设是血管周围间隙液体增加 在整个生命周期中我们还假设，个体差异存在于血管周围空间的功能， 人口统计学、一般健康和生活方式健康选择，如体重指数、血压、烟草 使用和睡眠质量。中心假设将通过表征的规范地图进行测试， 血管周围空间液体在整个生命周期中与各种人口统计学、认知测量相关， 健康因素。我们还将研究受试者的神经行为表现是否可以通过 血管周围间隙特征我们将通过应用创新的基于MRI的计算技术来实现这些目标。 技术，我们最近开发和优化的HCP数据。我们还将使用青少年大脑认知 发展（ABCD）研究，以建立第一个规范性模板PVS在神经发育。我们一起， 这些发现最终将使我们更好地了解人类大脑的清除系统， 血管周围空间标测工作流程可以为研究人员提供一种资源， 神经系统疾病

项目成果

Imaging perivascular space structure and function using brain MRI.

• DOI: 10.1016/j.neuroimage.2022.119329
• 发表时间: 2022-08-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Barisano, Giuseppe;Lynch, Kirsten M.;Sibilia, Francesca;Lan, Haoyu;Shih, Nien-Chu;Sepehrband, Farshid;Choupan, Jeiran
• 通讯作者: Choupan, Jeiran

Neuroimaging aspects and clinical significance of giant perivascular spaces in the brain.

大脑中巨大血管周围空间的神经影像学方面和临床意义。

• DOI: 10.21037/pcm-22-27
• 发表时间: 2022
• 期刊: Precision cancer medicine
• 作者: Barisano,Giuseppe

Brain perivascular space imaging across the human lifespan.

• DOI: 10.1016/j.neuroimage.2023.120009
• 发表时间: 2023-05-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Lynch, Kirsten M.;Sepehrband, Farshid;Toga, Arthur W.;Choupan, Jeiran
• 通讯作者: Choupan, Jeiran

Sex, gender diversity, and brain structure in children ages 9 to 11 years old.

9 至 11 岁儿童的性别、性别多样性和大脑结构。

• DOI: 10.1101/2023.07.28.551036
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Torgerson,Carinna;Ahmadi,Hedyeh;Choupan,Jeiran;Fan,ChunChieh;Blosnich,JohnR;Herting,MeganM
• 通讯作者: Herting,MeganM

Lateralization of Temporal Lobe Epilepsy Based on Resting-State Functional Magnetic Resonance Imaging and Machine Learning.

• DOI: 10.3389/fneur.2015.00184
• 发表时间: 2015
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Yang Z;Choupan J;Reutens D;Hocking J
• 通讯作者: Hocking J