Mapping human brain perivascular space in lifespan using human connectome project data

使用人类连接组项目数据绘制生命周期中的人脑血管周围空间

• 批准号: 10012731
• 负责人: Jeiran Choupan
• 金额: $ 133.65万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10012731
• 关键词: 3-Dimensional; Adolescent; Affect; Age; Aging; Anisotropy; BRAIN initiative; Biological; Blood Pressure; Body mass index; Brain; Brain region; Caliber; Cerebrospinal Fluid; Cognition; Cognitive; Communities; Computational Technique; Data; Data Analyses; Data Set; Deposition; Development; Diffuse; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Drug Delivery Systems; Early Diagnosis; Foundations; Future; Gatekeeping; Goals; Health; Heterogeneity; Human; Image; Immune system; Individual Differences; Intercellular Fluid; Knowledge; Life; Life Style; Light; Liquid substance; Longevity; Lymphatic; Machine Learning; Magnetic Resonance Imaging; Maps; Measures; Modeling; Morphology; National Institute of Mental Health; Neuroglia; Neurologic; Outcome; Participant; Pathologic; Pathway interactions; Pediatric cohort; Performance; Physiology; Process; Property; Public Health; Research; Research Personnel; Resolution; Resources; Robin bird; Role; Sample Size; Sampling; Short-Term Memory; Sleep; Smoking; Statistical Data Interpretation; Structure; System; T2 weighted imaging; Techniques; Testing; Tissues; Tobacco use; Variant; Visual; Walking; Work; age related; base; biophysical properties; brain health; cardiovascular health; cognitive development; cognitive function; cognitive performance; cohort; connectome; data archive; glymphatic system; human imaging; in vivo; innovation; insight; interest; lifestyle factors; neurobehavioral; neurodevelopment; neuroimaging; neurovascular unit; novel; sex; sleep quality; tool; wasting

PROJECT SUMMARY Perivascular spaces are a critical component of the glia-lymphatic circuit, facilitating the clearance of soluble waste. The role of perivascular spaces and changes in the brain’s clearance system in normal development, aging, and cognition is not fully understood, mainly due to lack of neuroimaging capabilities. However, noninvasive in vivo mapping of the perivascular space fluid with high accuracy and reliability is now made possible with our recent analytical developments, using human connectome project (HCP) data. The objective of this project is to map structural and diffusion features of perivascular space fluid across lifespan. PVS features include PVS presence (e.g., count and volume fraction) and diffusion (e.g., diffusivity and anisotropy). These features will be extracted regionally and globally across the brain. Structural MRI will provide information regarding localization and extent of the PVS and diffusion MRI will be used to investigate biophysical properties of the PVS fluid and surrounding tissue. The central hypothesis is that the perivascular space fluid increases across lifespan. We also hypothesize that individual differences exist in perivascular spaces as a function of demographic, general health and lifestyle health choices, such as body mass index, blood pressure, tobacco use and sleep quality. The central hypothesis will be tested by characterizing the normative map of the perivascular space fluid across the lifespan and in relation to various demographic, cognitive measures, and health factors. We will also examine whether subjects neuro-behavioral performances can be predicted by perivascular space features. We will pursue these aims by applying innovative MRI-based computational techniques that we recently developed and optimized on HCP data. We will also use Adolescent Brain Cognitive Development (ABCD) Studies to build first normative template of PVS in neurodevelopment. Together, our findings will ultimately allow for a better understanding of the human brain clearance system, and our shared perivascular space mapping workflow can provide a resource for researchers to study a wide range of neurological conditions.

项目总结

项目成果

Imaging perivascular space structure and function using brain MRI.

• DOI: 10.1016/j.neuroimage.2022.119329
• 发表时间: 2022-08-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Barisano, Giuseppe;Lynch, Kirsten M.;Sibilia, Francesca;Lan, Haoyu;Shih, Nien-Chu;Sepehrband, Farshid;Choupan, Jeiran
• 通讯作者: Choupan, Jeiran

Neuroimaging aspects and clinical significance of giant perivascular spaces in the brain.

大脑中巨大血管周围空间的神经影像学方面和临床意义。

• DOI: 10.21037/pcm-22-27
• 发表时间: 2022
• 期刊: Precision cancer medicine
• 作者: Barisano,Giuseppe

Brain perivascular space imaging across the human lifespan.

• DOI: 10.1016/j.neuroimage.2023.120009
• 发表时间: 2023-05-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Lynch, Kirsten M.;Sepehrband, Farshid;Toga, Arthur W.;Choupan, Jeiran
• 通讯作者: Choupan, Jeiran

Sex, gender diversity, and brain structure in children ages 9 to 11 years old.

9 至 11 岁儿童的性别、性别多样性和大脑结构。

• DOI: 10.1101/2023.07.28.551036
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Torgerson,Carinna;Ahmadi,Hedyeh;Choupan,Jeiran;Fan,ChunChieh;Blosnich,JohnR;Herting,MeganM
• 通讯作者: Herting,MeganM

Lateralization of Temporal Lobe Epilepsy Based on Resting-State Functional Magnetic Resonance Imaging and Machine Learning.

• DOI: 10.3389/fneur.2015.00184
• 发表时间: 2015
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Yang Z;Choupan J;Reutens D;Hocking J
• 通讯作者: Hocking J