Translational Oncology Training Program

转化肿瘤学培训计划

• 批准号: 10115676
• 负责人: Timothy Sebastian Pardee
• 金额: $ 27.6万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10115676
• 关键词: Oncology; Training Programs

Summary Cancer is the second leading cause of death in the US, and many challenges still remain to discover novel and more effective approaches to cure this devastating disease, which requires strong effort in translating basic science knowledge into clinics. To accomplish this goal and further promote translational cancer research, it is imperative to establish a sustainable program to train and educate the next generation of scientists and clinicians, who must have broad knowledge and the ability to communicate and work with colleagues in both fields. The goal of the Translational Oncology Training program (TOTP) is to ensure that the next generation of cancer researchers are equipped with the tools and knowledge that will enable them to bring bench-top discoveries into clinical trials and vice versa. The fellows and students in this program will receive unique training in four different but highly integrated themes: Preclinical Modeling (PCM); Cancer Image Guidance (CIG); Cancer Bio-Validation (CBV); and Clinical Translation (CLT). PCM focuses on analysis of pathways and signaling involved in tumor progression using various preclinical models in order to identify potential therapeutic targets and biomarkers. CIG provides training in state of the art image-guided diagnostic approaches and nanotechnology-based drug delivery systems. Trainees in CBV will learn up-to-date bioinformatics skills in multi-omics setting in order to study and analyze large cohort patient database. Preceptors in CLT have ample experiences in clinical trials and they provide guidance on how to translate basic knowledge into clinical trials. Trainees will rotate through three out of four themes during the first year while taking didactic lectures from all four themes. They will also assemble a mentoring team consisting of both Ph.D and MD faculty. The majority of preceptors of this T32 program are in the Hematology/Oncology and Cancer Biology departments. This structure merges strong clinical and basic science entities in the Wake Forest Baptist Comprehensive Cancer Center (WFBCCC). However, this training program is multidisciplinary and in all, preceptors come from 11 different departments. The program is unique with many innovative training tools: (i) highly integrated 4 translational themes that include both didactic lectures and hands-on rotations among the themes; (ii) inclusion of both Ph.D postdocs and MD fellows to promote both bench-to-bedside and bedside-to-benchtop translational cancer research; (iii) an individualized mentor team consisting of both Ph.D and MD faculty; (iv) boot camp for clinical trial preparation for trainees (v) support from Disease Oriented Teams (DOTs) from WFBCCC; (vi) Transition to Independence (TTI) program to support trainees to become independent through preparation for K-type applications; and (vii) Broad-base career opportunities and development plans such as Ph.D/MBA for graduate students. Therefore, through this training program, Ph.D fellows/students will learn how they can bring basic science knowledge into bedside, while MD fellows will have a deeper understanding of translational, hypothesis-driven research.

概括 癌症是美国第二大死亡原因，要发现新的和有效的治疗方法仍然面临许多挑战 更有效的方法来治愈这种毁灭性的疾病，这需要大力翻译基本原理 将科学知识带入临床。为了实现这一目标并进一步推动转化癌症研究， 当务之急是建立一个可持续的计划来培训和教育下一代科学家和 临床医生必须拥有广泛的知识以及与同事沟通和工作的能力 字段。转化肿瘤学培训计划 (TOTP) 的目标是确保下一个 一代癌症研究人员配备了工具和知识，使他们能够 将实验室发现带入临床试验，反之亦然。该计划的研究员和学生 将接受四个不同但高度集成的主题的独特培训：临床前建模（PCM）；癌症 图像引导（CIG）；癌症生物验证（CBV）；和临床翻译（CLT）。 PCM 注重分析 使用各种临床前模型研究肿瘤进展中涉及的途径和信号传导，以便识别 潜在的治疗靶点和生物标志物。 CIG 提供最先进的图像引导诊断培训 方法和基于纳米技术的药物输送系统。 CBV 的学员将学习最新的 多组学环境中的生物信息学技能，以便研究和分析大型队列患者数据库。 CLT 的导师拥有丰富的临床试验经验，他们提供如何转化的指导 临床试验的基础知识。第一年，学员将轮流学习四个主题中的三个 同时参加所有四个主题的教学讲座。他们还将组建一个由两者组成的指导团队 博士和医学博士教师。该 T32 计划的大多数导师来自血液学/肿瘤学和 癌症生物学系。这种结构融合了 Wake 中强大的临床和基础科学实体 森林浸信会综合癌症中心 (WFBCCC)。然而，这个培训计划是多学科的 总的来说，导师来自 11 个不同的部门。该计划独一无二，有许多创新培训 工具：(i) 高度整合的 4 个转化主题，包括教学讲座和实践轮换 主题之中； (ii) 纳入博士后和医学博士研究员，以促进从实验室到临床和 从床边到实验室的转化癌症研究； (iii) 由博士和博士组成的个性化导师团队 和医学博士教师； (iv) 为学员​​进行临床试验准备的训练营 (v) 疾病导向的支持 来自 WFBCCC 的团队（DOT）； (vi) 向独立过渡 (TTI) 计划，支持受训者成为 通过准备K类申请而独立； (vii) 广泛的职业机会和 研究生的博士/MBA等发展计划。因此，通过本次培训项目，博士生 研究员/学生将学习如何将基础科学知识带入临床，而医学博士研究员将有 对转化性、假设驱动的研究有更深入的了解。