PREDICTION OF CHEMOTHERAPY INDUCED CARDIOMYOPATHY WITH MRI DETECT I

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 阿霉素可以延长许多患有癌症的儿童和成人的生存时间，减轻肿瘤负担，但它的使用可能会导致不可逆转的充血性心力衰竭(CHF)。赫赛汀、紫杉醇和环磷酰胺也是广泛用于癌症治疗的药物，与心脏毒性有关。虽然在化疗过程中检测到的左心室射血分数(LVEF)下降可以预测CHF的发生，但它可能只有在遭受不可逆转的心脏损害后才会发生。 近年来，心血管磁共振成像(MRI)已被用于量化 左心室舒张期局部松弛的局部变化。对儿童的研究有 经常接受阿霉素治疗的患者左室舒张功能的有记录的改变 先于左心室射血分数恶化。从我们的 研究机构指出，MRI可用于检测高血压患者的左室舒张功能异常。 患者均有不同程度的LVEF。我们的目的是确定接受化疗的癌症患者的心脏毒性与核磁共振测量的左心室舒张期松弛或心肌灌注减少之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Doxorubicin prolongs survival and reduces tumor burden for many children and adults with cancer, but its use can cause irreversible congestive heart failure (CHF). Herceptin, Paclitaxel and Cyclophosphamide are also agents that are widely used for treatment of cancer and are associated with cardiotoxicity. Although a fall in left ventricular ejection (LVEF) detected during the course of chemotherapy may forecast the onset of CHF, it may occur only after irreversible cardiac damage has been sustained. Recently, cardiovascular magnetic resonance imaging (MRI) has been used to quantify regional changes in left ventricular diastolic regional relaxation. Studies in children have documented alterations in LV diastolic function in patients receiving Doxorubicin therapy often precede a deterioration in left ventricular ejection fraction. Pilot data generated from our institution indicates that MRI can be used to detect abnormalities of left ventricular relaxation in patients with varying degrees of LVEF. It is our intent to identify the association between cardiotoxicity and reductions in left ventricular diastolic relaxation or myocardial perfusion measured with MRI in cancer patients receiving chemotherapy.