Data Management & Analysis Core (DMAC)

数据管理与分析核心（Data Management and Analysis Core，DMAC） 数据管理和分析核心（DMAC）旨在加强LSU超级基金研究 计划（SRP）对环境持久性自由基（EPFRs）如何诱导 肺/心血管功能障碍，以及如何防止形成，增强衰变，并限制暴露于 EPFR的最终目标是改善人类健康和环境。五个项目和 支持LSU SRP中的核心提出了相当大的数据管理和生物统计挑战， 对中心的整体成功至关重要。DMAC的具体目标是（1）开发和实施 LSU SRP的综合数据管理计划;（2）开发和实施信息学解决方案， 包括数据收集、分发和分析工具，以及LSU SRP生成的数据的安全存储 项目和核心;（3）为SRP项目和核心提供统计专业知识;（4）为SRP项目和核心提供统计专业知识;（5）为SRP项目和核心提供统计专业知识。 应用和发展新的统计模型和方法分析复杂的 多维数据;（5）提供教育倡议和资源，为广大受众的研究生 学生，博士后研究人员和初级教师。DMAC成员拥有知识、技能和 处理复杂的多学科问题所需的经验，由路易斯安那州立大学SRP解决。我们 将利用路易斯安那州立大学系统的最新进展，实施全面的数据管理战略 在高速计算和数据分发中，沿着稳定和安全的数据收集、管理和 用于促进多学科协作的存储平台。我们的核心致力于促进 通过采用软件进行透明和可复制的研究，提供时间戳版本 对文档、文件和代码的控制，如开放科学框架和workflowr R包 用于统计分析。DMAC生物统计学家将扩大超级基金研究可用的工具集 通过开发新的途径和方法来理解EPFR之间的关系， 使用（多变量）多重中介分析，以及使用 可靠的机器学习方法，用于在微观结构路径研究中进行降维 EPFR形成和衰变机制的研究以及其他进展。最后，DMAC将发展和 促进各种形式和场所的广泛举措，以教育SRP调查人员，博士后 研究人员和研究生的主题，如有效的数据管理策略，研究设计 原则，并进行透明，有效，可推广和可重复的研究。

Project Summary/Abstract: Data Management and Analysis Core (DMAC) The Data Management and Analysis Core (DMAC) is designed to enhance the LSU Superfund Research Program's (SRP’s) understanding of how environmentally persistent free radicals (EPFRs) induce pulmonary/cardiovascular dysfunction, and how to prevent formation, enhance decay, and limit exposure to EPFRs, with the ultimate goal of improving human health and the environment. The five Projects and supporting Cores in the LSU SRP present considerable data management and biostatistical challenges that are crucial to the overall success of the Center. The DMAC’s Specific Aims are to (1) Develop and implement a comprehensive data management plan for LSU SRP; (2) Develop and implement informatics solutions, including data collection, distribution, and analysis tools and secure storage for data generated by LSU SRP Projects and Cores; (3) Provide statistical expertise to SRP Projects and Cores; (4) Provide expertise in the application and development of novel statistical models and methodology for analysis of complex multidimensional data; (5) Provide educational initiatives and resources to serve a wide audience of graduate students, postdoctoral researchers, and junior faculty. DMAC members possess the knowledge, skills, and experiences necessary for tackling the complex multi-disciplinary issues to be addressed by the LSU SRP. We will implement a comprehensive data management strategy leveraging recent advances within the LSU system in high-speed computing and data distribution, along with stable and secure data collection, management, and storage platforms for facilitating multi-disciplinary collaborations. Our Core is committed to promoting transparent and reproducible research through the adoption of software, providing time-stamped version control over documents, files, and code, such as the Open Science Framework and the workflowr R package for statistical analysis. The DMAC biostatisticians will expand the toolsets available to the Superfund research community by developing novel approaches and methods for understanding the relationship between EPFR exposures and respiratory health effects using (multivariate) multiple mediation analysis, as well as the use of reliable machine learning methods for dimension reduction in the investigation of the microstructural pathway of EPFR formation and decay mechanisms, among other advancements. Last, the DMAC will develop and promote a wide array of initiatives in various formats and venues for educating SRP investigators, postdoctoral researchers, and graduate students on topics such as effective data management strategies, study design principles, and on conducting transparent, valid, generalizable, and repeatable research.