Dissecting and modifying temporal dynamics underlying major depressive disorder

剖析和修改重度抑郁症背后的时间动态

基本信息

  • 批准号:
    10085101
  • 负责人:
  • 金额:
    $ 2.42万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-03-17 至 2023-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary of Work The purpose of this administrative supplement application is to provide support for Dr. Alexandra Bey, a psychiatry resident and neuroscience researcher, to expand her opportunities to carry out translational neuroscience research during her clinical training. By conducting the project outlined in this grant, Dr. Bey will gain invaluable experience in new scientific techniques, will study a behavior and its underlying neural dynamics extremely important to neuropsychiatric illnesses, and obtain personalized mentorship that will prepare her for an independent scientific career. To her accomplished skillset in molecular genetics and mouse behavior, she will develop electrophysiology and machine learning techniques in order to advance her ability to study neuronal circuits relevant to neurodevelopmental disorders. Through supervision by Dr. Kafui Dzirasa, Dr. Bey will receive intensive mentorship on experimental design, data analysis, manuscript publication, and grant-writing in order to prepare her to run a research group and compete for independent funding. Additionally, through regular counsel from a committee of preeminent clinician-scientists, Dr. Bey will obtain guidance and support for developing as a psychiatrist-neuroscientist as well as obtain relevant clinical exposure to patients with autism. Dr. Bey and Dr. Dzirasa have developed the following research project to investigate the neural dynamics of sleep. Furthermore, sleep as a behavior is quantifiable, translational, and frequently disrupted in many psychiatric and neurodevelopmental disorders. At present, there is very limited understanding of neural networks underlying sleep architecture. Dr. Bey’s experience with generating and characterizing different genetic mouse models of neuropsychiatric disorders uniquely poise her to advance her skillset to include techniques to truly dissect neural circuits, networks, and their dynamics. Utilizing Dr. Dzirasa’s expertise in in vivo electrophysiology, our collaborator Dr. David Carlson’s expertise in machine learning, we will support Dr. Bey in her efforts to: 1) obtain multisite in vivo electrophysiological recordings in mouse models of neuropsychiatric disease during sleep and wake states, 2) utilize machine-learning algorithms to identify altered neural circuit oscillations contributing to sleep architecture, and 3) extend this work to include a clinically relevant genetic manipulation to examine gene x stress interaction on the dynamics of sleep. Dr. Bey will be a key contributor to the development of each of these experiments and through their conduct, will develop expertise in measuring and understanding neural circuit function which will allow her to advance her career in studying the neurobiological basis of autism.
项目工作总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Kafui Dzirasa其他文献

Kafui Dzirasa的其他文献

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{{ truncateString('Kafui Dzirasa', 18)}}的其他基金

Precision editing of neural circuits using engineered electrical synapses
使用工程电突触精确编辑神经回路
  • 批准号:
    10487711
  • 财政年份:
    2022
  • 资助金额:
    $ 2.42万
  • 项目类别:
Precision editing of neural circuits using engineered electrical synapses
使用工程电突触精确编辑神经回路
  • 批准号:
    10700919
  • 财政年份:
    2022
  • 资助金额:
    $ 2.42万
  • 项目类别:
Dissecting and modifying temporal dynamics underlying major depressive disorder
剖析和修改重度抑郁症背后的时间动态
  • 批准号:
    10226122
  • 财政年份:
    2019
  • 资助金额:
    $ 2.42万
  • 项目类别:
Dissecting and modifying temporal dynamics underlying major depressive disorder
剖析和修改重度抑郁症背后的时间动态
  • 批准号:
    10670070
  • 财政年份:
    2019
  • 资助金额:
    $ 2.42万
  • 项目类别:
Dissecting and modifying temporal dynamics underlying major depressive disorder
剖析和修改重度抑郁症背后的时间动态
  • 批准号:
    10441495
  • 财政年份:
    2019
  • 资助金额:
    $ 2.42万
  • 项目类别:
Dissecting and modifying temporal dynamics underlying major depressive disorder
剖析和修改重度抑郁症背后的时间动态
  • 批准号:
    10004169
  • 财政年份:
    2019
  • 资助金额:
    $ 2.42万
  • 项目类别:
A fully biological platform for monitoring mesoscale neural activity
用于监测中尺度神经活动的全生物平台
  • 批准号:
    9764377
  • 财政年份:
    2018
  • 资助金额:
    $ 2.42万
  • 项目类别:
Characterizing sensorimotor gaiting dysfunction in mouse models of schizophrenia
精神分裂症小鼠模型感觉运动步态功能障碍的特征
  • 批准号:
    8582022
  • 财政年份:
    2013
  • 资助金额:
    $ 2.42万
  • 项目类别:
Characterizing sensorimotor gaiting dysfunction in mouse models of schizophrenia
精神分裂症小鼠模型感觉运动步态功能障碍的特征
  • 批准号:
    8701406
  • 财政年份:
    2013
  • 资助金额:
    $ 2.42万
  • 项目类别:
Enabling Stress Resistance
增强抗压能力
  • 批准号:
    9181453
  • 财政年份:
    2012
  • 资助金额:
    $ 2.42万
  • 项目类别:

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