MRI CONSOLE UPGRADE FOR SMALL-ANIMAL 12-T SCANNER

小动物 12-T 扫描仪的 MRI 控制台升级

• 批准号: 7794513
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 32.76万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-28 至 2012-01-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794513
• 关键词: Animal Disease Models; Animal Model; Animals; Architecture; Arts; Award; Biomedical Research; Cell Culture System; Characteristics; Clinic; Communities; Engineering; Evaluation; Event; Funding; Generations; Hamsters; Healthcare; Home environment; Image; Imaging Techniques; Injury; Institution; Laboratories; Laboratory Animal Models; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Imaging; Modeling; Molecular Biology; Morphologic artifacts; Mus; Noise; Pathology; Performance; Phase; Population; Procedures; Rattus; Research Personnel; Resources; Rodent; Running; Sampling; Science; Signal Transduction; Support System; System; Technology; Time; Transgenic Organisms; Translating; United States National Institutes of Health; Universities; Washington; cost effective; instrument; instrumentation; interest; magnetic field; member; method development; pre-clinical; programs; public health relevance; research study; tool

DESCRIPTION (provided by applicant): Small laboratory animal models such as mice, rats and hamsters are widely used throughout the biomedical research community at Washington University in St. Louis and other scientific institutions. With the recent revolution in molecular biology, transgenic laboratory animal models - in particular mice - have become an indispensable part of the biomedical research armamentarium. The identification and development of methods for analyzing and evaluating the characteristics of interest within animal models remains a significant challenge. This is especially true for longitudinal studies, in which members of a sample population are followed over an extended period. Clearly, invasive and/or destructive procedures - especially those that require sacrifice of the subject - are incompatible with such studies. Under these circumstances, nondestructive imaging procedures, such as those offered by magnetic resonance imaging (MRI), are especially valuable. This application from the Washington University Biomedical Magnetic Resonance Laboratory, home to the Washington University Small-Animal Imaging Resource, requests funds to purchase a state-of-the-art 11.74 tesla (500 MHz) MRI console from Varian NMR Systems, Palo Alto, CA. The 11.74 tesla small-animal MRI scanner in question was purchased with a 2002 NIH High-End Instrumentation award and is one of a handful of ultra high field scanners world-wide. It is heavily used in a variety of cross-disciplinary research studies, ranging from evaluation of cell culture systems to rodents, for which high signal-to-noise and contrast- to-noise ratios are critical. The requested console is Varian's new generation DirectDrive" instrument model, which replaces its long running INOVA" line. The current Varian INOVA console is outdated and unable to adequately support researchers who often push the limits of modern MRI science. Varian's DirectDrive console architecture represents a major leap in MR engineering technology, integration, and instrument performance. Importantly, the DirectDrive system supports parallel imaging in a cost effective manner. The console configuration requested includes four transmitter/receiver channels to enable parallel imaging via phased array coils. It also provides markedly superior in phase stability and event timing accuracy for fcMRI, qBOLD, and other demanding studies and can significantly reduce imaging artifacts through increased dynamic range and by eliminating quadrature imbalance. PUBLIC HEALTH RELEVANCE: Small-animal models of disease, pathology, and injury represent an important biomedical research tool. Magnetic resonance imaging provides a noninvasive and nondestructive means to translate preclinical findings from small-animal models to the clinic, directly impacting health care. This program requests funds to upgrade an ultra high magnetic field small-animal MRI scanner to enhance it capabilities, thereby supporting health care researchers.

描述（由申请人提供）：小鼠，大鼠和仓鼠等小型实验室动物模型在圣路易斯华盛顿大学和其他科学机构的整个生物医学研究界广泛使用。随着分子生物学的最新革命，转基因实验室动物模型（尤其是小鼠）已成为生物医学研究手臂的必不可少的一部分。分析和评估动物模型中感兴趣特征的方法的识别和开发仍然是一个重大挑战。对于纵向研究，尤其如此，在纵向研究中，在长时间内遵循样本人群的成员。显然，具有侵入性和/或破坏性程序，尤其是那些需要牺牲对象的程序 - 与此类研究不相容。在这种情况下，非破坏性成像程序（例如磁共振成像（MRI）提供的）尤其有价值。 华盛顿大学生物医学磁共振实验室的该应用程序是华盛顿大学小动物成像资源所在地，要求资金从CA的Varian NMR Systems，CA。有问题的11.74特斯拉小动物扫描仪是通过2002年NIH高端仪器奖购买的，是全球范围内少数超高野外扫描仪之一。它被大量用于各种跨学科研究，范围从对细胞培养系统的评估到啮齿动物，对于高信噪比和对比度和对比度至关重要。请求的控制台是Varian的New Generation DirectDrive“仪器模型，它取代了其长期运行的Inova”系列。目前的Varian Inova控制台已经过时，无法充分支持经常推动现代MRI科学局限的研究人员。 Varian的DirectDrive Console架构代表了MR工程技术，集成和仪器性能的重大飞跃。重要的是，DirectDrive系统以具有成本效益的方式支持并行成像。请求的控制台配置包括四个发射器/接收器通道，以通过相位阵列线圈启用并行成像。它还为FCMRI，Qbold和其他苛刻的研究提供了显着优越的相位稳定性和事件时序精度，并且可以通过增加动态范围并消除正交不平衡的情况，从而大大减少成像伪像。 公共卫生相关性：疾病，病理和损伤的小动物模型代表了重要的生物医学研究工具。磁共振成像提供了一种无创和无损的手段，可以将临床前发现从小动物模型转化为诊所，直接影响医疗保健。该计划要求资金升级超高磁场小动物MRI扫描仪以增强其功能，从而支持医疗保健研究人员。