MRI CONSOLE UPGRADE FOR SMALL-ANIMAL 12-T SCANNER

小动物 12-T 扫描仪的 MRI 控制台升级

• 批准号: 7794513
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 32.76万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-28 至 2012-01-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794513
• 关键词: Animal Disease Models; Animal Model; Animals; Architecture; Arts; Award; Biomedical Research; Cell Culture System; Characteristics; Clinic; Communities; Engineering; Evaluation; Event; Funding; Generations; Hamsters; Healthcare; Home environment; Image; Imaging Techniques; Injury; Institution; Laboratories; Laboratory Animal Models; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Imaging; Modeling; Molecular Biology; Morphologic artifacts; Mus; Noise; Pathology; Performance; Phase; Population; Procedures; Rattus; Research Personnel; Resources; Rodent; Running; Sampling; Science; Signal Transduction; Support System; System; Technology; Time; Transgenic Organisms; Translating; United States National Institutes of Health; Universities; Washington; cost effective; instrument; instrumentation; interest; magnetic field; member; method development; pre-clinical; programs; public health relevance; research study; tool

DESCRIPTION (provided by applicant): Small laboratory animal models such as mice, rats and hamsters are widely used throughout the biomedical research community at Washington University in St. Louis and other scientific institutions. With the recent revolution in molecular biology, transgenic laboratory animal models - in particular mice - have become an indispensable part of the biomedical research armamentarium. The identification and development of methods for analyzing and evaluating the characteristics of interest within animal models remains a significant challenge. This is especially true for longitudinal studies, in which members of a sample population are followed over an extended period. Clearly, invasive and/or destructive procedures - especially those that require sacrifice of the subject - are incompatible with such studies. Under these circumstances, nondestructive imaging procedures, such as those offered by magnetic resonance imaging (MRI), are especially valuable. This application from the Washington University Biomedical Magnetic Resonance Laboratory, home to the Washington University Small-Animal Imaging Resource, requests funds to purchase a state-of-the-art 11.74 tesla (500 MHz) MRI console from Varian NMR Systems, Palo Alto, CA. The 11.74 tesla small-animal MRI scanner in question was purchased with a 2002 NIH High-End Instrumentation award and is one of a handful of ultra high field scanners world-wide. It is heavily used in a variety of cross-disciplinary research studies, ranging from evaluation of cell culture systems to rodents, for which high signal-to-noise and contrast- to-noise ratios are critical. The requested console is Varian's new generation DirectDrive" instrument model, which replaces its long running INOVA" line. The current Varian INOVA console is outdated and unable to adequately support researchers who often push the limits of modern MRI science. Varian's DirectDrive console architecture represents a major leap in MR engineering technology, integration, and instrument performance. Importantly, the DirectDrive system supports parallel imaging in a cost effective manner. The console configuration requested includes four transmitter/receiver channels to enable parallel imaging via phased array coils. It also provides markedly superior in phase stability and event timing accuracy for fcMRI, qBOLD, and other demanding studies and can significantly reduce imaging artifacts through increased dynamic range and by eliminating quadrature imbalance. PUBLIC HEALTH RELEVANCE: Small-animal models of disease, pathology, and injury represent an important biomedical research tool. Magnetic resonance imaging provides a noninvasive and nondestructive means to translate preclinical findings from small-animal models to the clinic, directly impacting health care. This program requests funds to upgrade an ultra high magnetic field small-animal MRI scanner to enhance it capabilities, thereby supporting health care researchers.

描述（申请人提供）：小鼠、大鼠、仓鼠等小型实验动物模型广泛应用于圣路易斯华盛顿大学等科研机构的生物医学研究界。随着近年来分子生物学的革命，转基因实验动物模型，特别是小鼠，已经成为生物医学研究宝库中不可或缺的一部分。确定和发展分析和评估动物模型中感兴趣的特征的方法仍然是一个重大挑战。这对于纵向研究来说尤其如此，在这种研究中，一个样本群体的成员被跟踪了很长一段时间。显然，侵入性和/或破坏性的程序——尤其是那些需要牺牲受试者的程序——与此类研究是不相容的。在这种情况下，非破坏性成像程序，如磁共振成像（MRI）提供的，是特别有价值的。华盛顿大学生物医学磁共振实验室是华盛顿大学小动物成像资源的所在地，该申请要求从加州帕洛阿尔托的瓦里安核磁共振系统公司购买一台最先进的11.74特斯拉（500 MHz）核磁共振控制台。该11.74特斯拉小动物核磁共振扫描仪是2002年美国国立卫生研究院高端仪器奖购买的，是世界上少数超高场扫描仪之一。它被大量用于各种跨学科的研究，从评估细胞培养系统到啮齿动物，其中高信噪比和对比度噪声比是至关重要的。所要求的控制台是瓦里安的新一代DirectDrive“仪表模型，取代了其长期运行的INOVA”系列。目前的瓦里安INOVA控制台已经过时，无法充分支持经常推动现代MRI科学极限的研究人员。瓦里安的DirectDrive控制台架构代表了MR工程技术、集成和仪器性能的重大飞跃。重要的是，DirectDrive系统以经济有效的方式支持并行成像。要求的控制台配置包括四个发送/接收通道，以通过相控阵线圈实现并行成像。它还为fcMRI、qBOLD和其他要求苛刻的研究提供了明显优越的相位稳定性和事件定时精度，并且可以通过增加动态范围和消除正交不平衡来显著减少成像伪影。