UC Davis Comparative Oncology Training Program

项目概要/摘要 临床前动物模型已经成为开发新型癌症疗法的基础。历史上， 这个基金会一直依赖于小鼠模型。虽然小鼠模型非常重要，但模型 不足，需要补充。伴侣动物是远系繁殖的重要组合 具有自发性癌症发展的动物，具有完整的免疫系统，并且具有环境 和表观遗传暴露。解决复杂的癌症研究问题应包括 研究人员在动物和人类物种方面拥有广泛的经验，为我们提供了一个独特的机会， DVM和MD在基础到转化研究中发挥关键作用。兽医可以加强 比较方法对多学科研究至关重要，加速了动物的创新治疗 还有人类医生带来了以病人为中心的方法，将生物学与临床治疗联系起来。 不幸的是，招募和留住具有比较肿瘤学专业知识的生物医学科学家，特别是 DVM或MD临床科学家，仍然是更广泛的研究界面临的一个具有挑战性的问题。 比较肿瘤学培训计划（T32）将提供出色的培训环境 对癌症研究感兴趣的博士前（DVM/PhD）学生和博士后DVM或博士后MD研究员。到 为了实现这一目标，陈博士、肯特博士和坎特博士（MPI）组织了一个由27名加州大学戴维斯分校成员组成的多元化团队 来自兽医学院，医学院，生物科学学院， 农业与环境科学学院和工程学院。教师导师是 获得NCI或癌症相关资金的生物医学研究人员。该计划将利用 NCI指定的加州大学戴维斯分校综合癌症中心，并将完全融入该中心的 癌症教育计划。T32计划的目标是：1）招募和保留一个多元化的群体， 临床科学家，使他们准备成为未来的领导者在学术界，政府服务和公众 健康，2）使T32学者接触以癌症为重点的职业道路，以及3）培训学者使用 比较医学来解决人类癌症生物学。这些目标将通过提供 为DVM/PhD双学位博士前学生和博士后DVM或博士后MD提供3年资助 博士后在培训期间，T32学者将通过量身定制的 课程作业、指导研究、多学科互动和职业发展活动。年底 在资助期内，我们预计将培养11名专业人员，其中包括两名双学位DVM/PhD 学生，七个后DVM研究员，和两个后MD研究员成为高素质的基础和翻译 比较肿瘤学研究者。

Project Summary/Abstract Preclinical animal models have been the foundation for the development of novel cancer therapies. Historically, this foundation has relied on mouse models. While mouse models are fundamentally important, the models are insufficient and need to be complemented. Companion animals are an important combination of outbred animals that have spontaneous cancer development with an intact immune system and have environmental and epigenetic exposures as humans. Tackling complex cancer research problems should include investigators with broad experience across animal and human species presenting a unique opportunity for DVMs and MDs to have a crucial role in basic to translational research. Veterinarians can strengthen comparative approaches essential to multidisciplinary research accelerating innovative treatments for animals and humans. Medical doctors bring a patient-centered approach linking biology with clinical therapy. Unfortunately, recruiting and retaining biomedical scientists with comparative oncology expertise, especially DVM or MD clinician-scientists, continues to be a challenging issue facing the broader research community. The Comparative Oncology Training Program (T32) will provide an outstanding environment to train predoctoral (DVM/PhD) students and post-DVM or post-MD fellows who are interested in cancer research. To accomplish this goal, Drs. Chen, Kent, and Canter (MPIs) organized a diverse team of twenty-seven UC Davis faculty mentors from the School of Veterinary Medicine, School of Medicine, College of Biological Science, College of Agricultural and Environmental Sciences, and College of Engineering. The faculty mentors are accomplished biomedical investigators with NCI or cancer-related funding. The proposed program will leverage the NCI-designated UC Davis Comprehensive Cancer Center and will be fully integrated into the Center’s cancer education program. The T32 program’s objectives are to: 1) recruit and retain a diverse group of clinician-scientists that prepares them to become future leaders in academia, government service and public health, 2) expose the T32 scholars to cancer-focused career paths, and 3) train the scholars to use comparative medicine to address human cancer biology. The objectives will be accomplished by providing up to 3-year funding support for DVM/PhD dual-degree predoctoral students and post-DVM or post-MD postdoctoral fellows. During the training, the T32 scholars will enhance their knowledge through tailored coursework, mentored research, multidisciplinary interactions, and career development activities. By the end of the grant period, we expect to train eleven professionals encompassing two dual-degree DVM/PhD students, seven post-DVM fellows, and two post-MD fellows to become highly-qualified basic and translational comparative oncology researchers.