UC Davis Comparative Oncology Training Program

项目摘要/摘要 临床前动物模型一直是开发新的癌症治疗方法的基础。从历史上看， 这一基础依赖于老鼠模型。虽然鼠标模型在根本上很重要，但这些模型 这是不够的，需要加以补充。伴侣动物是近亲繁殖的重要组合 有自发性癌症发生的动物，具有完整的免疫系统和环境 以及人类的表观遗传暴露。解决复杂的癌症研究问题应该包括 研究人员在动物和人类物种方面拥有丰富的经验，为 DVM和MD在基础到翻译研究中发挥关键作用。兽医可以增强 对多学科研究至关重要的比较方法加速动物创新治疗 和人类。医学医生带来了以患者为中心的方法，将生物学与临床治疗联系起来。 不幸的是，招募和留住具有比较肿瘤学专业知识的生物医学科学家，特别是 DVM或MD临床医生-科学家，仍然是更广泛的研究界面临的一个具有挑战性的问题。 比较肿瘤学培训计划(T32)将提供良好的培训环境 对癌症研究感兴趣的博士后(DVM/PhD)学生和DVM或MD后研究员。至 为了实现这一目标，陈博士、肯特博士和坎特博士(MPIS)组织了一个由加州大学戴维斯分校27人组成的多元化团队 来自兽医学院、医学院、生物科学学院的教师导师， 农业与环境科学学院和工程学院。教职员工导师是 拥有NCI或癌症相关基金的资深生物医学研究人员。拟议中的计划将利用 NCI指定的加州大学戴维斯综合癌症中心，并将完全整合到该中心的 癌症教育项目。T32计划的目标是：1)招聘和留住不同的群体 临床医生--培养他们成为学术界、政府部门和公共部门未来领导者的科学家 健康，2)让T32学者接触以癌症为重点的职业道路，以及3)培训学者使用 研究人类癌症生物学的比较医学。这些目标将通过提供 为DVM/博士双学位博士后和DVM后或MD后提供为期3年的资助 博士后研究员。在培训期间，T32学者将通过量身定做的方式增进知识 课程、辅导性研究、多学科互动和职业发展活动。到了最后 在资助期内，我们预计将培训11名专业人员，包括两个双学位DVM/博士学位 学生、7名DVM后研究员和2名MD后研究员成为高资质的基础和翻译人员 比较肿瘤学研究人员。

Project Summary/Abstract Preclinical animal models have been the foundation for the development of novel cancer therapies. Historically, this foundation has relied on mouse models. While mouse models are fundamentally important, the models are insufficient and need to be complemented. Companion animals are an important combination of outbred animals that have spontaneous cancer development with an intact immune system and have environmental and epigenetic exposures as humans. Tackling complex cancer research problems should include investigators with broad experience across animal and human species presenting a unique opportunity for DVMs and MDs to have a crucial role in basic to translational research. Veterinarians can strengthen comparative approaches essential to multidisciplinary research accelerating innovative treatments for animals and humans. Medical doctors bring a patient-centered approach linking biology with clinical therapy. Unfortunately, recruiting and retaining biomedical scientists with comparative oncology expertise, especially DVM or MD clinician-scientists, continues to be a challenging issue facing the broader research community. The Comparative Oncology Training Program (T32) will provide an outstanding environment to train predoctoral (DVM/PhD) students and post-DVM or post-MD fellows who are interested in cancer research. To accomplish this goal, Drs. Chen, Kent, and Canter (MPIs) organized a diverse team of twenty-seven UC Davis faculty mentors from the School of Veterinary Medicine, School of Medicine, College of Biological Science, College of Agricultural and Environmental Sciences, and College of Engineering. The faculty mentors are accomplished biomedical investigators with NCI or cancer-related funding. The proposed program will leverage the NCI-designated UC Davis Comprehensive Cancer Center and will be fully integrated into the Center’s cancer education program. The T32 program’s objectives are to: 1) recruit and retain a diverse group of clinician-scientists that prepares them to become future leaders in academia, government service and public health, 2) expose the T32 scholars to cancer-focused career paths, and 3) train the scholars to use comparative medicine to address human cancer biology. The objectives will be accomplished by providing up to 3-year funding support for DVM/PhD dual-degree predoctoral students and post-DVM or post-MD postdoctoral fellows. During the training, the T32 scholars will enhance their knowledge through tailored coursework, mentored research, multidisciplinary interactions, and career development activities. By the end of the grant period, we expect to train eleven professionals encompassing two dual-degree DVM/PhD students, seven post-DVM fellows, and two post-MD fellows to become highly-qualified basic and translational comparative oncology researchers.