UC Davis Comparative Oncology Training Program

加州大学戴维斯分校比较肿瘤学培训计划

• 批准号: 10686927
• 负责人: Robert J. Canter
• 金额: $ 29.05万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686927
• 关键词: Oncology; Training Programs; comparative

Project Summary/Abstract Preclinical animal models have been the foundation for the development of novel cancer therapies. Historically, this foundation has relied on mouse models. While mouse models are fundamentally important, the models are insufficient and need to be complemented. Companion animals are an important combination of outbred animals that have spontaneous cancer development with an intact immune system and have environmental and epigenetic exposures as humans. Tackling complex cancer research problems should include investigators with broad experience across animal and human species presenting a unique opportunity for DVMs and MDs to have a crucial role in basic to translational research. Veterinarians can strengthen comparative approaches essential to multidisciplinary research accelerating innovative treatments for animals and humans. Medical doctors bring a patient-centered approach linking biology with clinical therapy. Unfortunately, recruiting and retaining biomedical scientists with comparative oncology expertise, especially DVM or MD clinician-scientists, continues to be a challenging issue facing the broader research community. The Comparative Oncology Training Program (T32) will provide an outstanding environment to train predoctoral (DVM/PhD) students and post-DVM or post-MD fellows who are interested in cancer research. To accomplish this goal, Drs. Chen, Kent, and Canter (MPIs) organized a diverse team of twenty-seven UC Davis faculty mentors from the School of Veterinary Medicine, School of Medicine, College of Biological Science, College of Agricultural and Environmental Sciences, and College of Engineering. The faculty mentors are accomplished biomedical investigators with NCI or cancer-related funding. The proposed program will leverage the NCI-designated UC Davis Comprehensive Cancer Center and will be fully integrated into the Center’s cancer education program. The T32 program’s objectives are to: 1) recruit and retain a diverse group of clinician-scientists that prepares them to become future leaders in academia, government service and public health, 2) expose the T32 scholars to cancer-focused career paths, and 3) train the scholars to use comparative medicine to address human cancer biology. The objectives will be accomplished by providing up to 3-year funding support for DVM/PhD dual-degree predoctoral students and post-DVM or post-MD postdoctoral fellows. During the training, the T32 scholars will enhance their knowledge through tailored coursework, mentored research, multidisciplinary interactions, and career development activities. By the end of the grant period, we expect to train eleven professionals encompassing two dual-degree DVM/PhD students, seven post-DVM fellows, and two post-MD fellows to become highly-qualified basic and translational comparative oncology researchers.

项目摘要/摘要 临床前动物模型一直是新型癌症疗法发展的基础。从历史上看 该基础在鼠标模型上放松了。尽管鼠标模型在根本上很重要，但模型是 不足，需要完成。伴侣动物是杂交的重要组合 具有赞助商样癌症的动物具有完整的免疫系统，并且具有环境 和表观遗传暴露为人类。解决复杂的癌症研究问题应包括 在动物和人类中拥有丰富经验的调查人员为带来独特的机会 DVM和MD在翻译研究中具有至关重要的作用。兽医可以加强 多学科研究必不可少的比较方法加速了动物的创新治疗 和人类。医生带来了一种以患者为中心的方法，将生物学与临床疗法联系起来。 不幸的是，招募和保留具有比较肿瘤专业知识的生物医学科学家，尤其是 DVM或MD临床科学家仍然是更​​广泛的研究社区面临的挑战问题。 比较肿瘤学培训计划（T32）将为培训提供杰出的环境 对癌症研究感兴趣的前DVM或DVM或MD后研究员。到 实现这一目标，博士。陈，肯特和坎特（MPI）组织了一支由二十七个加州大学戴维斯的潜水员团队 生物科学学院医学院兽医学院的教师导师， 农业与环境科学学院和工程学院。教师导师是 具有NCI或与癌症相关的资金的成熟生物医学研究人员。拟议的计划将利用 NCI指定的UC Davis综合癌症中心将完全融入该中心 癌症教育计划。 T32计划的目标是：1） 临床科学家准备成为学术界，政府服务和公众的未来领导者 健康，2）将T32学者暴露于以癌症为中心的职业道路上，3）训练学者使用 比较医学来解决人类癌症生物学。目标将通过提供 为DVM/PHD双学位学生和DVM或DVM或MD后的三级资金支持3年的资金支持 博士后研究员。在培训期间，T32学者将通过量身定制来增强他们的知识 课程工作，指导的研究，多学科互动和职业发展活动。到最后 在赠款期内，我们希望培训11位专业人员，包括两个双度DVM/PHD 学生，七个DVM后的研究员和两个MD后的研究员成为高素质的基本和翻译 比较肿瘤学研究人员。

项目成果

Is Improved Survival in Early-Stage Pancreatic Cancer Worth the Extra Cost at High-Volume Centers?

• DOI: 10.1016/j.jamcollsurg.2021.02.014
• 发表时间: 2021-07
• 期刊: Journal of the American College of Surgeons
• 影响因子: 5.2
• 作者: Perry LM;Bateni SB;Bold RJ;Hoch JS
• 通讯作者: Hoch JS

Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy.

• DOI: 10.3390/jdb10010011
• 发表时间: 2022-02-08
• 期刊: Journal of developmental biology
• 影响因子: 2.7
• 作者: Lee SY;Loll EG;Hassan AS;Cheng M;Wang A;Farmer DL
• 通讯作者: Farmer DL

ASO Author Reflections: Deescalating Therapy for Older Men with Early Estrogen Receptor Positive Breast Cancer.

• DOI: 10.1245/s10434-020-09357-x
• 发表时间: 2021-05
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Perry LM;Bateni SB;Sauder CAM
• 通讯作者: Sauder CAM

Building a Culture of Support at a Pediatric Surgery Center Through Multidisciplinary Peer Support.

通过多学科同伴支持在小儿外科中心建立支持文化。

• DOI: 10.1016/j.jss.2023.04.029
• 发表时间: 2023
• 期刊: The Journal of surgical research
• 作者: Doyle,Kathleen;Murray,Trudee;Fong,IanC;Chavez,Angela;Rounds,Ginger;Linenberger,Michelle;Wieck,Minna
• 通讯作者: Wieck,Minna

AMDOPARVOVIRUS INFECTIONS ARE PREVALENT, PERSISTENT, AND GENETICALLY DIVERSE IN ZOO-HOUSED RED PANDAS (AILURUS FULGENS).

• DOI: 10.1638/2021-0082
• 发表时间: 2022-03
• 期刊: JOURNAL OF ZOO AND WILDLIFE MEDICINE
• 影响因子: 0.7
• 作者: Alex, Charles E.;Kubiski, Steven, V;Jackson, Kenneth A.;Wack, Raymund F.;Pesavento, Patricia A.
• 通讯作者: Pesavento, Patricia A.