SensiTrak: Automated Assessment of Forelimb Sensation

SensiTrak：前肢感觉自动评估

基本信息

批准号：
10259383
负责人：
Andrew Michael Sloan
金额：
$ 25.64万
依托单位：
VULINTUS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10259383
关键词：
Animal Model Animal Testing Animals Architecture Behavior Behavioral Clinic Collaborations Complex Computer software Custom Data Detection Development Discrimination Disease Engineering Esthesia Feedback Forelimb Functional disorder Genetic Human Impairment Injury Intuition Laboratories Lesion Letters Libraries Market Research Measurement Measures Medial lemniscus Methods Modality Modeling Modernization Movement Mus Needs Assessment Neurology Pain Pathway interactions Patients Perception Peripheral Phase Physiology Process Proprioception Psychophysics Rattus Recovery Recovery of Function Research Research Personnel Rodent Rodent Model Sensory Small Business Technology Transfer Research Spinal cord injury Standardization Stimulus System Temperature Testing Texture Touch sensation Training Translating Universities Validation Volition Withdrawal Work base behavior measurement chronic pain clinically relevant design dorsal column flexibility innovation member neural circuit novel open source operation pre-clinical prototype response software development somatosensory tool

项目摘要

Project Abstract In this Phase I STTR project, Vulintus, Inc., in collaboration with Columbia University, proposes to develop and test ‘SensiTrak,’ an automated, high-throughput behavioral system designed to finely measure somatosensory function in rodent models. Current common methods for measuring somatosensory function in rodent models generally rely on withdrawal responses to uncomfortable or painful stimuli. These tests can be stressful to the animal, while also yielding a high variability in measured responses, and repetitive testing in longitudinal models may even result in chronic pain states. To better understand the connection between physiology and perception of touch and proprioception, researchers need a modern, off-the-shelf assessment system to administer and quantify trained, volitional behaviors. SensiTrak will meet these needs by supporting complex, electromechanical feedback interactions with animals, with interchangeable task modules, behavioral peripherals, and open-source behavioral software. Phase I work will focus on finalization and bench testing of the SensiTrak prototype design and validation testing with a rat model of somatosensory-specific impairment.

项目摘要在I阶段I STTR项目，Vulintus，Inc。，与哥伦比亚大学合作，提案为了开发和测试“敏感性”，这是一个自动化的高通量行为系统在啮齿动物模型中测量体感功能。当前的常见方法测量啮齿动物模型中的体感功能通常依赖于提取反应不舒服或痛苦的刺激。这些测试可能会给动物带来压力，同时也产生测得的响应的高度可变性，纵向模型中的重复测试甚至可能甚至可能导致慢性疼痛状态。更好地了解生理学和触摸和本体感受的感知，研究人员需要现代的现成评估管理和量化经过训练的自愿行为的系统。 Sensitrak将满足这些需求通过支持复合物与动物的机电反馈相互作用，可互换的任务模块，行为外围设备和开源行为软件。第一阶段的工作将重点介绍灵敏度原型设计的最终确定和台式测试用大鼠特定于特异性损伤的大鼠模型进行验证测试。