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Generating new mouse mutant strains

Generating new mouse mutant strains
产生新的小鼠突变品系
批准号：
10266648
负责人：
Karl Eric Pfeifer
金额：
$81.82万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10266648
关键词：
CRISPR/Cas technologyES Cell LineEmbryoEnhancersEpigenetic ProcessGene Expression RegulationGenome StabilityGoalsHematopoiesisImmune systemImplantInjectionsIntramural Research ProgramIronMalariaModelingMutant Strains MiceMutateNational Institute of Child Health and Human DevelopmentOperative Surgical ProceduresPathway interactionsProtocols documentationRNAResearchResearch PersonnelResearch SupportRiskScientistSignal PathwayT-Cell DevelopmentThymus GlandUnited States National Institutes of HealthWorkblastocystdesignembryonic stem cellimmune functionmouse modelnovelstem cell biologyzygote

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中文摘要
翻译
在过去的一年里，我们的研究核心与NIH的十个研究单位合作，产生了新的胚胎干细胞系和新的小鼠模型（8个项目，包括6个CRISPR/Cas9合子注射）。本研究包括建立免疫系统信号通路相互作用、T细胞发育、造血、干细胞生物学、早期胚胎表观遗传、基因组稳定性调控机制、RNA代谢、基因调控和增强子功能、铁代谢与疟疾风险等方面的模型。我们还进行了专门的手术，包括胸腺植入，以支持免疫功能的研究。
英文摘要
During the last year our research core has worked with ten NIH research units to generate novel embryonic stem cell lines and new mouse models (8 projects, including 6 CRISPR/Cas9 Zygote injections). This research included establishment of models to study signal pathway interactions in the immune system, T cell development, hematopoiesis, stem cell biology, epigenetic inheritance in the early embryo, mechanisms regulating genomic stability, RNA metabolis, gene regulation and enhancer function, and iron methabolism and malaria risk. We also performed specialized surgeries including thymus implants to support research on immune function.
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