课题基金 / 基金详情

Generating new mouse mutant strains

Generating new mouse mutant strains
产生新的小鼠突变品系
批准号：
10266648
负责人：
Karl Eric Pfeifer
金额：
$81.82万
依托单位：
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10266648
关键词：
CRISPR/Cas technologyES Cell LineEmbryoEnhancersEpigenetic ProcessGene Expression RegulationGenome StabilityGoalsHematopoiesisImmune systemImplantInjectionsIntramural Research ProgramIronMalariaModelingMutant Strains MiceMutateNational Institute of Child Health and Human DevelopmentOperative Surgical ProceduresPathway interactionsProtocols documentationRNAResearchResearch PersonnelResearch SupportRiskScientistSignal PathwayT-Cell DevelopmentThymus GlandUnited States National Institutes of HealthWorkblastocystdesignembryonic stem cellimmune functionmouse modelnovelstem cell biologyzygote

项目摘要

项目成果

Karl Eric Pfeifer的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
During the last year our research core has worked with ten NIH research units to generate novel embryonic stem cell lines and new mouse models (8 projects, including 6 CRISPR/Cas9 Zygote injections). This research included establishment of models to study signal pathway interactions in the immune system, T cell development, hematopoiesis, stem cell biology, epigenetic inheritance in the early embryo, mechanisms regulating genomic stability, RNA metabolis, gene regulation and enhancer function, and iron methabolism and malaria risk. We also performed specialized surgeries including thymus implants to support research on immune function.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Analysis of Imprinting on Mouse Distal Chromosome 7
Analysis Of Imprinting On Mouse Distal Chromosome 7
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
Generating new mouse models
海外基金