Generating new mouse mutant strains
Generating new mouse mutant strains
批准号:
9339954
负责人:
Karl Eric Pfeifer
金额:
$56.41万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Bone MatrixBrainCryopreservationES Cell LineEmbryoEnhancersEpigenetic ProcessExtracellular MatrixGene Expression RegulationGoalsHematopoiesisHereditary DiseaseImmune systemInjection of therapeutic agentIntramural Research ProgramMetabolismModelingMusMutant Strains MiceMutateNational Institute of Child Health and Human DevelopmentPathway interactionsProtocols documentationRNAResearchResearch PersonnelScientistSignal PathwayT-Cell DevelopmentUnited States National Institutes of HealthWorkblastocystcancer geneticsdesignembryonic stem cellmalignant endocrine gland neoplasmmouse modelneurogenesisnovelstem cell biology
中文摘要
在过去的一年里,我们的研究核心与9个NIH研究单位合作,创造了新的胚胎干细胞系(23个项目)和新的小鼠模型(21个项目)。这项研究包括建立模型,研究发育和成熟大脑中的神经发生,免疫系统中的信号通路相互作用,T细胞发育,造血,干细胞生物学,早期胚胎的表观遗传,RNA代谢,骨和细胞外基质的遗传障碍,基因调节和增强功能,以及内分泌和癌症遗传学。我们还对三个研究单位的16个小鼠品系进行了冷冻保存。
英文摘要
During the last year our research core has worked with nine NIH research units to generate novel embryonic stem cell lines (23 projects) and new mouse models (21 projects). This research included establishment of models to study neurogenesis in developing and mature brains, signal pathway interactions in the immune system, T cell development, hematopoiesis, stem cell biology, epigenetic inheritance in the early embryo, RNA metabolism, genetic disorders in bone and extracellular matrix, gene regulation and enhancer function, and endocrine and cancer genetics. We also performed cryopreservation of 16 mouse lines for three research units.
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专著(0)
科研奖励(0)
会议论文
Analysis of Imprinting on Mouse Distal Chromosome 7
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批准号:6432581
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6813784
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8351152
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项目类别:
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资助金额:$81.9万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Generating new mouse models
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批准号:10908197
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项目类别:
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资助金额:$91.98万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6992966
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6671892
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Regulated expression and developmental functions of the H19 long noncoding RNA
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批准号:10685191
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项目类别:
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资助金额:$141.43万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:10266483
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项目类别:
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资助金额:$151.95万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6541232
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:7968609
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项目类别:
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资助金额:$75.04万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8553889
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项目类别:
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资助金额:$92.42万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8736854
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项目类别:
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资助金额:$141.41万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Generating new mouse mutant strains
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批准号:9790852
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项目类别:
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资助金额:$62.49万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Regulated expression and developmental functions of the H19 long noncoding RNA
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批准号:10908167
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项目类别:
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资助金额:$170.83万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:7734744
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项目类别:
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资助金额:$71.68万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:9339250
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项目类别:
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资助金额:$104.76万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:7334055
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Generating new mouse mutant strains
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批准号:10266648
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项目类别:
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资助金额:$81.82万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8941473
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项目类别:
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资助金额:$103.44万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8149286
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项目类别:
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资助金额:$64.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
国内基金
海外基金
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批准号:81801389
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批准年份:2018
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平扫描数据导引的超低剂量Brain-PCT成像新方法研究
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资助金额:23.0万元
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批准年份:2011
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依托单位: