Generating new mouse mutant strains
Generating new mouse mutant strains
批准号:
9339954
负责人:
Karl Eric Pfeifer
金额:
$56.41万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Bone MatrixBrainCryopreservationES Cell LineEmbryoEnhancersEpigenetic ProcessExtracellular MatrixGene Expression RegulationGoalsHematopoiesisHereditary DiseaseImmune systemInjection of therapeutic agentIntramural Research ProgramMetabolismModelingMusMutant Strains MiceMutateNational Institute of Child Health and Human DevelopmentPathway interactionsProtocols documentationRNAResearchResearch PersonnelScientistSignal PathwayT-Cell DevelopmentUnited States National Institutes of HealthWorkblastocystcancer geneticsdesignembryonic stem cellmalignant endocrine gland neoplasmmouse modelneurogenesisnovelstem cell biology
中文摘要
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英文摘要
During the last year our research core has worked with nine NIH research units to generate novel embryonic stem cell lines (23 projects) and new mouse models (21 projects). This research included establishment of models to study neurogenesis in developing and mature brains, signal pathway interactions in the immune system, T cell development, hematopoiesis, stem cell biology, epigenetic inheritance in the early embryo, RNA metabolism, genetic disorders in bone and extracellular matrix, gene regulation and enhancer function, and endocrine and cancer genetics. We also performed cryopreservation of 16 mouse lines for three research units.
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会议论文
Analysis of Imprinting on Mouse Distal Chromosome 7
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批准号:6432581
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6813784
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8351152
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项目类别:
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资助金额:$81.9万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Generating new mouse models
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批准号:10908197
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项目类别:
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资助金额:$91.98万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6992966
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6671892
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Regulated expression and developmental functions of the H19 long noncoding RNA
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批准号:10685191
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项目类别:
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资助金额:$141.43万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:10266483
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项目类别:
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资助金额:$151.95万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:6541232
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:7968609
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项目类别:
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资助金额:$75.04万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Generating new mouse mutant strains
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批准号:9790852
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项目类别:
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资助金额:$62.49万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8553889
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项目类别:
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资助金额:$92.42万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8736854
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项目类别:
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资助金额:$141.41万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:7734744
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项目类别:
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资助金额:$71.68万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Regulated expression and developmental functions of the H19 long noncoding RNA
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批准号:10908167
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项目类别:
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资助金额:$170.83万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:9339250
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项目类别:
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资助金额:$104.76万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Analysis Of Imprinting On Mouse Distal Chromosome 7
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批准号:7334055
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Generating new mouse mutant strains
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批准号:10266648
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项目类别:
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资助金额:$81.82万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8941473
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项目类别:
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资助金额:$103.44万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
Epigenetic mechanisms regulating the Igf2/H19 and Kcnq1 locus
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批准号:8149286
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项目类别:
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资助金额:$64.0万
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财政年份:--
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负责人:Karl Eric Pfeifer
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依托单位:
国内基金
海外基金
Sitagliptin通过microbiota-gut-brain轴在2型糖尿病致阿尔茨海默样变中的脑保护作用机制
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批准号:81801389
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项目类别:青年科学基金项目
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资助金额:21.0万元
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批准年份:2018
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负责人:田茗源
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依托单位:
平扫描数据导引的超低剂量Brain-PCT成像新方法研究
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批准号:81101046
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资助金额:23.0万元
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批准年份:2011
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负责人:黄静
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依托单位: