An Observational Cross-Sectional Study of Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease

视网膜疾病功能性视觉虚拟现实移动性评估的观察横断面研究

• 批准号: 10266922
• 负责人: Brett Jeffrey
• 金额: $ 23.69万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10266922
• 关键词: Affect; Age; Area; Assessment tool; Biological Markers; COVID-19 pandemic; Clinic Visits; Clinical; Clinical Trials; Clinical Trials Design; Color Visions; Consumption; Contrast Sensitivity; Cross-Sectional Studies; Floor; Goals; Hour; Learning; Measures; Outcome Measure; Participant; Patients; Performance; Play; Questionnaires; Reality Testing; Retina; Retinal Diseases; Severities; Structure; Suspensions; Testing; Time; Vision; Visual Acuity; Visual Fields; Visual impairment; base; computer game; disability; experience; functional outcomes; physically handicapped; primary outcome; recruit; secondary outcome; tool; virtual reality; walking speed

The primary outcome is to determine whether parameters from a recently developed VR mobility tool can serve as biomarkers of functional vision in participants with retinal disease. To this end, we will examine the correlation between VR mobility test parameters (e.g., accuracy, task time) and the mobility score from a PRO questionnaire/s. Secondary outcomes include: 1. The correlation between VR mobility test parameters (e.g., accuracy, task time) and clinical measures of retinal structure and function (e.g. visual acuity, non-seeing area). 2. Learning effect on and test-retest variability of the VR test parameters. 3. Sensitivity of VR mobility test parameters to the presence and severity of retinal disease. 4. Feasibility of the tool based on age and presence of physical disabilities. 5. The effect of prior or present computer game playing (e.g., number of hours, type of games played, computer game platform) on baseline performance on the VR mobility tool. Although we were notified of approval on February 3, 2020 we have not be able to start recruiting for the study due to suspension of clinics visits since March due to the COVID19 pandemic.

主要结果是确定最近开发的VR移动工具的参数是否可以作为视网膜疾病参与者的功能性视力的生物标志物。 为此，我们将检查VR移动性测试参数之间的相关性（例如，准确性、任务时间）和来自PRO问卷的移动性评分。 次要结局包括： 1. VR移动性测试参数之间的相关性（例如，准确性、任务时间）和视网膜结构和功能的临床测量（例如，视敏度、非视区）。 2. VR测试参数的学习效应和重测变异性。 3. VR移动性测试参数对视网膜疾病的存在和严重程度的敏感性。 4. 基于年龄和身体残疾的工具的可行性。 5. 先前或当前计算机游戏的影响（例如，小时数、玩的游戏类型、计算机游戏平台）对VR移动性工具的基线性能的影响。 尽管我们于2020年2月3日收到批准通知，但由于COVID 19大流行自3月以来暂停了诊所访视，我们无法开始招募研究人员。