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National Institute on Drug Abuse Clinical Trial Network: New England Consortium Node

国家药物滥用研究所临床试验网络：新英格兰联盟节点

基本信息

批准号：
10573954
负责人：
Gail D'Onofrio
金额：
$ 10.55万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-30 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10573954
关键词：
Accident and Emergency department Address Aftercare Age Attitude Behavioral Black Populations Black race Buprenorphine Cessation of life Clinical Trials Network Data Analyses Development Discrimination Emergency Department patient Emergency Department-based Intervention Emergency Medicine Emergency department visit Enrollment Ethnic Origin Face Formulation Future Goals Health Services Research Healthcare Systems Helping to End Addiction Long-term Individual Injectable Institution Interview Knowledge Latino Latino Population Link Location Major Depressive Disorder Medicine Methadone National Institute of Drug Abuse New England Opioid Participant Patients Pattern Perception Pharmaceutical Preparations Population Positioning Attribute Public Health Race Randomized Clinical Trials Research Research Methodology Rural Series Services Social Policies Stimulant Structure Suboxone Survivors Treatment outcome United States National Institutes of Health Validation addiction base buprenorphine treatment comparative efficacy depressive symptoms improved innovation novel opioid epidemic opioid mortality opioid overdose opioid use disorder overdose death polysubstance use primary outcome racial and ethnic racial and ethnic disparities social stigma suburb

项目摘要

PROJECT SUMMARY In recent years there has been a marked surge in opioid overdose deaths across Black and Latino populations. Addiction treatment, which includes medications for opioid use disorder (MOUD) such as buprenorphine, decreases fatal opioid overdoses. Yet Black and Latino individuals face substantial disparities in access to MOUD and addiction treatment. The emergency department (ED) represents an emerging setting to initiate MOUD and provide linkage to ongoing addiction treatment to Black and Latino individuals with untreated opioid use disorder (OUD). However, little is known about the barriers and facilitators that Black and Latino individuals encounter to engage in addiction treatment subsequent to an ED visit. Moreover, less is known about the differences in ED presentation for opioid overdose, polysubstance use, major depressive disorder, and stigma within these populations. Filling these knowledge gaps are important because opioid overdose, polysubstance use, major depressive disorder, and stigma have each been linked to worse treatment outcomes. Further, eliciting barriers and facilitators can inform future ED-based interventions to enhance engagement in addiction treatment among Black and Latino individuals with untreated OUD. The goal of this proposal is to evaluate disparities in access to addiction treatment and elicit potential targets for ED-based interventions that enhance engagement in addiction treatment among Black and Latino populations. The specific aims are to: 1) conduct a qualitative study focusing on patterns of barriers and facilitators to engaging in addiction treatment among Black, Latino, and non-Latino White patients receiving ED-initiated buprenorphine treatment with a referral for continuation of OUD treatment outside of the ED and 2) evaluate differences among Black, Latino, and non- Latino White ED patients with untreated OUD on factors previously identified as predictors of worse treatment outcome, including opioid overdose, polysubstance use, major depressive disorder, and stigma, using supplemental analyses of data collected in CTN 0099. To accomplish this, we will conduct both semi-structured individual interviews of Black, Latino, and non-Latino White participants enrolled in CTN 0099 after they have completed their final 30-day assessments and supplemental analyses from data collected in CTN 0099. Study findings will inform the development of an ED-based intervention that enhances engagement in addiction treatment among Black and Latino populations subsequent to ED visit.

项目总结