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Bilateral integration of the auditory scene

听觉场景的双边整合

基本信息

批准号：
10570878
负责人：
CHARLES C LEE
金额：
$ 36.16万
依托单位：
LOUISIANA STATE UNIV A&M COL BATON ROUGE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10570878
关键词：
Acoustics Affect Aging Auditory Auditory system Behavior Bilateral Binaural Binding Brain Brain Stem Cells Central Auditory Processing Disorder Complement Contralateral Development Diagnosis Diagnostic Disease Ear Equilibrium Esthesia Failure Future Glutamates Goals Health Hearing problem Impaired cognition Impairment In Vitro Inferior Inferior Colliculus Injections Investigation Ipsilateral Knowledge Language Disorders Lasers Light Link Longevity Medial geniculate body Mediating Methods Midbrain structure Mission Modernization Mus Nerve Degeneration Neuroanatomy Neurons Outcome Pathologic Pathway interactions Pattern Physiological Population Presbycusis Preventive measure Process Productivity Property Public Health Quality of life Research Role Scanning Scheme Signal Transduction Slice Societies Source Stimulus Structure Synapses System Techniques Testing Therapeutic Therapeutic Intervention Tinnitus Tracer Trauma United States National Institutes of Health Viral auditory pathway auditory processing auditory stimulus auditory thalamus behavioral impairment cell type diagnostic strategy experience experimental study improved in vivo information processing innovation neural neural circuit neuromechanism neurophysiology normal hearing optogenetics prevent prospective response sound source localization therapeutic target

项目摘要

ABSTRACT The auditory system is posed with answering a challenging question: Does sound arriving at each ear originate from a single source or multiple sources? To accomplish this perceptual feat, central auditory neural circuits must accurately assess the spectral and temporal profile of bilateral sound signals to bind and integrate related acoustic objects. Failure of this bilateral integrative process can account for many of the perceptual and behavioral impairments that accompany auditory disorders, such as tinnitus, presbycusis and central auditory processing disorders, which most of the population will experience over the lifespan. Surprisingly, the neural mechanisms that enable this bilateral integration of acoustic information remain largely unknown, but likely depend on an intricate balance of excitatory and inhibitory connections that link the two halves of the auditory brain. Although commissural pathways have been well studied in auditory brainstem centers, much less is known about the functional organization of commissural circuitry in higher centers of the auditory brain. Thus, the long- term goals of our research are to understand the functional organization of the commissural pathways in the processing of bilateral auditory information. Our primary objective here is to test a largely overlooked, yet substantial, commissural auditory projection system, i.e. the pathway from the inferior colliculus to the contralateral medial geniculate body. Our central hypothesis is that the medial geniculate body integrates functionally and topographically aligned inputs from both the ipsilateral and contralateral inferior colliculi at a cell- type specific level. Further, we hypothesize that the disruption of such bilateral tectothalamic convergence results in deficits to the spectral and temporal processing of acoustic information in the medial geniculate body, which contributes to disorders of the central auditory system. We will test our hypotheses by assessing: 1) the functional neuroanatomy and 2) the neurophysiological impact of these contralateral tectothalamic pathways on auditory processing, by employing modern, cell-type specific neuroanatomical and neurophysiological approaches. As such, these studies are innovative since they address the unknown and unexplored functional organization of the contralateral auditory tectothalamic pathways. Finally, the proposed experiments are significant since they are expected to reveal mechanistic features of auditory processing that will have a positive impact for neural diagnostics and treatments for central auditory impairments.

摘要