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Social, Developmental and Epidemiology of Alcohol Use Disorders

酒精使用障碍的社会、发育和流行病学

基本信息

批准号：
10581566
负责人：
KENNETH SEEDMAN KENDLER
金额：
$ 49.73万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10581566
关键词：
Academic achievement Acculturation Acquaintances Address Affect Age Alcohols Birth Cardiovascular system Caring Childhood Clinical Communities Couples Data Data Sources Development Disease Economics Environmental Risk Factor Epidemiology Etiology Extended Family Family Funding Generations Genetic Genetic Models Genetic Risk Geographic Locations Geography Goals Health Heterogeneity Hospitals Hypertension Immigrant Immigration Individual International Classification of Disease Codes Intervention Laws Marital Relationships Marital Status Marriage Mediating Mediator Medical Mental Depression Mental disorders Methodology Methods Morbidity - disease rate Natural experiment Nature Nuclear Family Obesity Onset of illness Outcome Parents Partner in relationship Pathway interactions Pattern Performance Personality Pharmaceutical Preparations Phenotype Policies Population Prevention Primary Care Process Productivity Psychological Models Psychopathology Randomized Records Recurrence Refugees Registries Research Resources Risk Risk Assessment Risk Factors Role Sampling Sex Differences Siblings Social outcome Specialist Statistical Methods Structural Models Sweden Testing Typology Universities Virginia Woman Work alcohol consequences alcohol epidemiology alcohol exposure alcohol risk alcohol use disorder causal model comorbidity contagion data registry deprivation design disorder risk epidemiological model genetic analysis genetic pedigree grandchild high risk improved indexing insight medical complication member men offspring protective factors psychiatric comorbidity psychosocial residence sex social social model sociodemographic factors transmission process

项目摘要

Project Summary We seek, in this revision of our renewal application, to build on the findings of our productive first project period that was focused on advancing our understanding of risk and protective factors for, and the consequences of, Alcohol Use Disorder (AUD). In the next funding period, we will apply our epidemiological and methodological expertise to examine the following facets of AUD: the etiology and consequences of its phenotypic heterogeneity; the influence of specific causal factors; the nature and etiology of the medical consequences of AUD; the transmission of AUD within marital pairs, nuclear families and extended pedigrees and the impact of acculturation on risk for AUD in various immigrant groups. These goals all utilize the wide range of data available from multiple nationwide data sources in Sweden on 11.8 million men and women, 26% of whom are 1st- or 2nd-generation immigrants. These data are of unparalleled completeness and depth and have recently been expanded to include a Swedish primary care registry (PCR) created by our team. Our first specific aim seeks to address the important problem of the heterogeneity of AUD by applying latent class analysis to develop an optimal typology of AUD in all affected cases in Sweden. We will then validate this using a split-half design and determine how these subtypes are associated with key risk factors and whether subtypes are differentially associated with psychosocial and medical sequelae of AUD. Our second aim uses standard and newly developed methods of causal inference to examine the impact of poor academic achievement on AUD risk, and evaluate, in two different ways, promising models for the psychological transmission of AUD within families. We will here utilize a range of natural experiments available in Swedish registry data. Our third aim will capitalize on the newly available PCR and other medical registers to determine the temporal, genetic, and environmental relationships between AUD and both classical alcohol-related medical complications and common medical morbidities such as cardiovascular illness, hypertension and obesity. Our fourth aim will explore the transmission of AUD risk within large pedigrees and marital relationships using three major strategies: advanced SEM methods; exploration within three-generation pedigrees of features of second generation members who do versus do not transmit AUD to the third generation; and study of the multiple ways in which various marital outcomes can impact on the risk for and the course of AUD. Our final aim will examine, among immigrants to Sweden, how rates of AUD are modified by acculturation. Applying the expertise of our research groups at Virginia Commonwealth and Lund University in AUD research, social and genetic epidemiology, and causal modeling to a uniquely powerful sample, we will be able to improve risk assessment and offer insight for promising prevention/intervention targets for AUD and its consequences.

项目概要在更新申请的本次修订中，我们力求以我们富有成效的第一个项目期间的发现为基础重点是增进我们对风险和保护因素及其后果的理解，酒精使用障碍（AUD）。在下一个资助期内，我们将应用我们的流行病学和方法论检查 AUD 以下方面的专业知识：其表型的病因及其后果异质性；具体因果因素的影响；医疗后果的性质和病因澳元； AUD 在婚姻伴侣、核心家庭和大谱系中的传播及其影响不同移民群体对澳元风险的文化适应。这些目标都利用了广泛的数据瑞典多个全国数据源提供了 1,180 万名男性和女性的数据，其中 26% 第一代或第二代移民。这些数据具有无与伦比的完整性和深度，并且最近已扩展到包括我们团队创建的瑞典初级保健登记处 (PCR)。我们的第一个具体目标试图通过应用潜在类别分析来解决 AUD 异质性的重要问题针对瑞典所有受影响病例制定 AUD 的最佳类型。然后我们将使用分半验证这一点设计并确定这些亚型如何与关键风险因素相关，以及这些亚型是否与 AUD 的社会心理和医疗后遗症存在不同的相关性。我们的第二个目标使用标准和新开发的因果推理方法，用于检查学业成绩不佳对 AUD 的影响风险，并以两种不同的方式评估 AUD 心理传播的有希望的模型家庭。我们将在这里利用瑞典注册数据中提供的一系列自然实验。我们的第三个目标将利用新可用的 PCR 和其他医学登记来确定时间、遗传和 AUD 与典型的酒精相关医疗并发症和心血管疾病、高血压和肥胖等常见疾病。我们的第四个目标是使用三个主要的方法探索 AUD 风险在大谱系和婚姻关系中的传播策略：先进的SEM方法；在三代谱系中探索第二代的特征传授澳元与不传授澳元给第三代的一代成员；和多重研究各种婚姻结局对 AUD 风险和病程产生影响的方式。我们的最终目标是研究瑞典移民中澳元汇率如何因文化适应而改变。应用我们弗吉尼亚联邦大学和隆德大学研究小组在 AUD 研究、社会和遗传流行病学以及对独特强大样本的因果建模，我们将能够提高风险评估并为 AUD 及其后果的有希望的预防/干预目标提供见解。

项目成果

期刊论文数量（50）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Alcohol use disorder and divorce: evidence for a genetic correlation in a population-based Swedish sample.

DOI：
10.1111/add.13719
发表时间：
2017-04
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Salvatore JE;Larsson Lönn S;Sundquist J;Lichtenstein P;Sundquist K;Kendler KS
通讯作者：
Kendler KS

The rearing environment and the risk for alcohol use disorder: a Swedish national high-risk home-reared v. adopted co-sibling control study.