Data Integration and Quality Core

约翰霍普金斯AITC的目标是深刻的数据密集型，在大多数情况下，将涉及大型 整合不同临床数据的努力。数据集成和质量核心将促进 试点研究者之间的联系和开发新的 以及改善老年人健康的适销产品。患者风险的范围， 干预参数和结果包括大量电子健康记录（EHR）数据。 本提案的目的是：（1）确保所有得到支持的AITC项目得到审查和优化， 建立在数据质量和管理基础上的数据质量和利用的最高标准 约翰霍普金斯医学院和公共卫生学院的可用资源，2） 为不同的数据整合和集成提供一个通用平台， 霍普金斯的资源非常适合这个目的。约翰霍普金斯精准医学平台 （PMAP）为数据集成和分析提供了一个安全、健壮和灵活的基于云的框架。 我们的核心将审查所有的概念提案和试点应用，并帮助确保，3）协调 在可行的情况下，将跨源和域的通用数据元素转换为规范标准。我们将 使用富含HL 7 FHIR源的OHDSI-OMOP标准，用于电子健康记录数据，开放 用于设备数据集成的mHealth和CommonHealth以及通用术语服务增强了 FHIR术语服务器功能通过UMLS、caDSR和NCI同义词库进行增强， 语义数据集成完成这些目标将有助于确保相关的数据模式 包括患者报告的信息、调查和传感器数据将被整合到连贯的渲染中 可以支持机器学习发现或统计评估的推理。我们还将帮助 确保作为任何人工智能或技术的一部分收集的任何人工智能或技术相关数据 通过此AITC的开发应用程序将以这样的方式进行审查和组织， 快速用于开发旨在改善健康和健康的特定产品- 作为老年人。在这一努力中，重要的是约翰霍普金斯精确医学的发展 分析平台（PMAP），为获批临床研究构建的数据收集和分析系统 基于患者的临床数据，开发并维护为 约翰霍普金斯医学院和约翰霍普金斯应用物理实验室加速 生物医学发现我们在开发和实施该数据平台方面的经验将 使来自全国各地的试点研究调查员。在此基础上，以及数据平台方面的专业知识 和电子健康记录研究，我们建议支持所有试点的发展和完成， 根据以下具体目标，在JH AITC内开展项目。

The goals of the Johns Hopkins AITC are profoundly data intensive, and in most cases will involve large efforts that incorporate disparate clinical data. The Data Integration and Quality Core will facilitate the connections between pilot study investigators and appropriate data connection needed to develop new and marketable products that improve the health of older adults. The spectrum of patient risks, intervention parameters, and outcomes comprise a large swath of electronic health record (EHR) data. The aims of this proposal are 1) to ensure that all supported AITC projects are reviewed and optimized to the highest standards of data quality and utilization building on the data quality and management resources available across the Johns Hopkins School of Medicine and the School of Public Health, 2) to provide a common platform for disparate data consolidation and integration, leveraging available resources at Hopkins ideally suited for this purpose. The Johns Hopkins Precision Medicine Platform (PMAP) provides a secure, robust, and flexible cloud-based framework for data integration and analyses. Our core will review all concept proposals and pilot applications and help to ensure, and 3) to harmonize common data elements across sources and domains into a canonical standard where practical. We will use the OHDSI-OMOP standards enriched with HL7 FHIR feeds for Electronic Health Record data, Open mHealth and CommonHealth for device data integration, and Common Terminology Services enhance FHIR Terminology Server functionality augmented with UMLS, caDSR, and the NCI Thesaurus for semantic data integration. Completion of these aims will help to ensure that related modalities of data including patient reported information, surveys, and sensor data will be integrated into coherent renderings that can sustain inferencing for machine learning discovery or statistical evaluation. We will also help to assure that any AI or technology related data collected as part of any artificial intelligence or technology development application that comes thru this AITC will be vetted and organized in such a way that it can be quickly utilized in the development of specific products that are meant to improve the health and well- being of older adults. Important in this effort is the development of the Johns Hopkins Precision Medicine Analytics Platform (PMAP), a data collection and analysis system built for approved clinical research based upon clinical data of patients was developed and is maintained as a collaboration between the Johns Hopkins School of Medicine and the Johns Hopkins Applied Physics Laboratory to accelerate biomedical discovery. Our experience in the development and implementation this data platform will enable pilot study investigators from across the country. Building on this, and expertise in data platform and electronic health record research, we propose to support the development and completion of all pilot projects within the JH AITC according to the following specific aims.