A National Center for Digital Health Informatics Innovation

项目总结 在过去的十年里，CTSA在开发信息学工具和服务方面取得了令人难以置信的进步 支持机构或以中心为中心的翻译研究。然而，集线器之间的强大协作是 要实现CTSA网络的全部潜力，这是一个协作和共享的活生生的生态系统。我们 汇聚了开放科学、临床和生物医学信息学、健康科学图书馆、 以及NCATS翻译器倡议，提议创建国家数字医疗创新中心，以 将CTSA信息学社区与开放科学社区联合起来，以催化下一步 生物医学信息学发展的几个步骤。我们将创建一个开放的治理模式，包括所有人 世卫组织愿意参与并协作制定下一步行动。我们将接受一个‘想法’ 实施‘模式(I2I)，支持建立协作开发的可持续基础设施。我们 将通过开放数据、开放软件、开放资源的轴心，通过两个集成的主题 迫切需要的领域：罕见疾病和人类终身健康。这些努力的基础是 评估、培训和创建社区挑战的创新模式，以此作为机制 激发新的、有影响力的工具和方法。我们将利用开放和团队科学的力量 展示新的研究机会的方法。我们的领导层包括俄勒冈健康科学公司 约翰·霍普金斯大学、华盛顿大学、圣路易斯华盛顿大学、 西北大学、Sage BioNetworks、杰克逊实验室和斯克里普斯研究所。我们 有来自翻译信息学所有领域的合作者，包括医疗记录供应商、临床研究 开放软件和开放数据领域的网络和领导者。我们的共同努力将推动 临床和转化性研究的国家信息学基础设施的演变。

PROJECT SUMMARY Over the past decade, the CTSAs have made incredible progress in developing informatics tools and services to support institutional or hub-centric translational research. However, robust collaboration between the hubs is required to realize the full potential of the CTSA network, a living ecosystem of collaboration and sharing. We have brought together pioneers of open science, clinical and biomedical informatics, health science libraries, and the NCATS Translator initiative to propose the creation of a National Center for Digital Health Innovation to coalesce the CTSA informatics community together with the open science community to catalyze the next steps in the evolution of biomedical informatics. We will create an open governance model that includes all who would like to participate and collaboratively forge the next steps. We will embrace an ‘idea to implementation’ model (I2I), supporting the creation of collaboratively developed sustainable infrastructure. We will do this via the axes of open data, open software, open resources, and through two integrated thematic areas of urgent need: rare disease and human health across the lifespan. Underpinning these efforts are innovative models for evaluation, training, and the creation of community challenges as mechanisms to stimulate new and impactful tools and methods. We will leverage the power of an open and team science approach to demonstrate new research opportunities. Our leadership include Oregon Health Sciences University, Johns Hopkins University, the University of Washington, Washington University in St. Louis, Northwestern University, Sage BioNetworks, the Jackson Laboratory and the Scripps Research Institute. We have collaborators from all areas of translational informatics including health record vendors, clinical research networks and leaders in open software and open data. Together our efforts will catalyze the next stage in the evolution of the national informatics infrastructure for clinical and translational research.