SCENTinel: A Rapid Smell Test for COVID-19 Surveillance

SCENTinel：用于 COVID-19 监测的快速气味测试

• 批准号: 10264616
• 负责人: PAMELA HELEN DALTON
• 金额: $ 50.27万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-21 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10264616
• 关键词: 2019-nCoV; Age; Anosmia; Area; Awareness; Biological Testing; Biomedical Research; COVID-19; COVID-19 diagnosis; COVID-19 patient; COVID-19 screening; COVID-19 surveillance; COVID-19 testing; Caring; Chemicals; Child; Collaborations; Communities; Complement; Data; Data Coordinating Center; Data Set; Demographic Survey; Detection; Development; Diagnostic tests; Ensure; Exhibits; Fever; Food; Foundations; Foxes; General Population; Goals; Gold; Health Benefit; Health care facility; Human; Individual; Industrialization; Longevity; Measures; Medical; Monitor; Nursing Homes; Odors; Olfaction Disorders; Outcome; Participant; Patient Self-Report; Performance; Phase; Population Heterogeneity; Population Surveillance; Prevalence; Protocols documentation; Psychometrics; Quarantine; Race; Recommendation; Reporting; Research; Respondent; SARS-CoV-2 infection; SARS-CoV-2 negative; SARS-CoV-2 positive; Safety; Schools; Scientist; Screening procedure; Self Administration; Sensitivity and Specificity; Site; Smell Perception; Standardization; Subacute Care; Swab; Symptoms; Taste Perception; Technology Transfer; Test Result; Testing; Time; United States National Institutes of Health; Universities; Validation; Viral; Work; Workplace; accurate diagnosis; aged; base; coronavirus disease; cost; dalton; density; design; early onset; evidence base; experience; insight; instrument; interest; multidisciplinary; nasal swab; patient response; performance tests; salivary assay; screening; sex; smell test; success; symptomatology; tool; tv watching

PROJECT SUMMARY Smell loss is a predominant symptom of COVID-19, and initial evidence based on self-reports suggests that chemosensory loss is a sensitive predictor of COVID-19 in the general population, more so than fever. However, given the natural lack of awareness of chemosensory changes, self-reports underestimate the true prevalence of smell loss in patients with COVID-19 by 20% compared to an objective test. Therefore, we propose testing and deploying a rapid and objective measure of smell ability, the SCENTinel test, inspired by the NIH Toolbox® Odor Identification Test that our team previously developed. SCENTinel is an inexpensive, and convenient smell test for COVID-19 surveillance of the population that quickly and easily assesses three smell loss factors: odor detection, odor intensity, and odor identification. It is designed for practical use in several contexts, including high-density areas such as community medical sites, universities, subacute care facilities, and both industrial and nonindustrial workplaces. Our multi-disciplinary team has expertise in understanding taste and smell, developing and validating chemosensory tests, as well as studying the broad symptomatology of COVID-19. The group is led by MPI Dalton from the Monell Chemical Senses Center, an expert in human olfaction and designing olfactory tests; MPI Parma from Temple University is an expert in COVID-19 smell loss, is the Chair of the Global Consortium for Chemosensory Research, and has expertise in conducting research in rapidly changing situations; Dr. Schalet and his team at Northwestern University and Dr. Chun and his team at Yale University, among the other established and interested partners (Fox subacute nursing homes, Hormel Food). Our team also includes the Director of Technology Transfer at the Monell Center, Dr. O’Leary, to explore potential partners and expand SCENTinel deployment nationwide. Dr. Reed from the Monell Chemical Senses Center will work directly with the Data Coordination Center, drawing on her experience in managing large shared NIH datasets. All will work closely with the NIH Project Scientist. This proposal aims to a) fine-tune SCENTinel’s ability to predict a positive COVID-19 diagnostic test; b) examine marginal smell loss as a sign of the earliest phases of COVID-19, before a positive diagnostic test; and c) assess the test’s psychometric validity with test-retest reliability measures and validation against the NIH Toolbox® Odor Identification Test. Together, these aims will establish a standardized protocol for use of SCENTinel as a rapid and objective smell test that can easily be incorporated into onsite COVID-19 testing centers, schools, and workplaces nationwide. Furthermore, it will provide key insights into early-onset chemosensory symptoms in relation to a confirmed COVID-19 diagnosis, providing a crucially needed means to contain the spread of COVID-19.

项目摘要 气味丧失是Covid-19的主要症状，基于自我报告的初始证据表明， 化学感应损失是Covid-19在普通人群中的敏感预测指标，而不是发烧。 但是，鉴于自然缺乏对化学感觉变化的认识，自我报告低估了真实 与客观测试相比，COVID-19患者的气味降低20％的患病率降低了20％。因此，我们 提案测试和部署气味能力的快速和客观测量，灵感来自Scentinel测试 我们团队先前开发的NIHToolbox®气味识别测试。 Scentinel是一个便宜的， 和方便的气味测试，以迅速而轻松评估的人口进行19009的监视 三种气味损失因素：气味检测，气味强度和气味识别。它旨在实际使用 几种环境，包括高密度领域，例如社区医疗网站，大学，亚急性护理 设施，以及工业和非工业工作场所。我们的多学科团队在 了解口味和气味，开发和验证化学感应测试，并研究广泛 COVID-19的症状学。该组由Monell Chemical Senses Center的MPI Dalton领导， 人类嗅觉和设计嗅觉测试的专家；来自坦普尔大学的MPI Parma是 Covid-19气味丧失，是全球化学感应研究联盟的主席，并具有专业知识 在快速变化的情况下进行研究； Schalet博士和他在西北大学的团队以及 Chun博士及其在耶鲁大学的团队，以及其他建立且有趣的合作伙伴（Fox Subcute 护士房屋，荷米尔食品）。我们的团队还包括Monell的技术转移总监 中心O'Leary博士探索潜在的合作伙伴并扩大全国范围内的Scentinel部署。里德博士 从Monell化学感官中心中心将直接与数据协调中心合作 管理大型共享NIH数据集的经验。所有人都将与NIH项目科学家紧密合作。这 提案旨在a）微调Scentinel预测阳性COVID-19诊断测试的能力； b）检查 在阳性诊断测试之前，边缘气味丧失是Covid-19的最早阶段的标志；和c） 通过测试可靠性措施和针对NIH的验证评估测试的心理测量有效性 Toolbox®气味识别测试。这些目标共同建立了使用的标准化协议 香气作为快速而客观的气味测试，可以轻松地掺入现场Covid-19 全国中心，学校和工作。此外，它将为早期发作提供关键的见解 与确认的Covid-19诊断有关的化学感应症状，提供完全需要的手段 以包含COVID-19的传播。