Conduct of studies to evaluate the toxic potential of C9-alkylbenzenes in laboratory animals

该项目的目标是为转化毒理学司（DTT）的危险识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性测试是公共卫生研究的一个重要方面,它是确定化学物质对人体健康有害。需要进行适当的毒理学研究，以确保得出的数据可靠。本项目涉及通过全身吸入接触c9 -烷基苯（包括1,2,4-三甲苯、2-乙基甲苯和混合二甲苯）后的毒性表征。人类很可能同样通过吸入接触到这些化合物。该项目的数据将用于制定关于1,2,4-三甲苯、2-乙基甲苯和混合二甲苯对大鼠和小鼠的潜在毒性和致癌性的合理科学结论，并最终支持数字地面电视的使命和目标以及其他联邦机构的风险评估活动。此外，公众可充分了解因接触1,2,4-三甲苯、2-乙基甲苯和混合二甲苯而产生的风险因素。

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves characterization of the toxicity of C9-alkylbenzenes, including 1,2,4-trimethylbenzene, 2-ethyltoluene, and mixed xylenes, following exposure via whole body inhalation. Humans are likely to be similarly exposed to these compounds via inhalation. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of 1,2,4-trimethylbenzene, 2-ethyltoluene and mixed xylenes in rats and mice and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to 1,2,4-trimethylbenzene, 2-ethyltoluene and mixed xylenes. Keywords: toxicity, inhalation, trimethylbenzene, ethyltoluene, xylene, lung