Conduct of studies to evaluate the toxic potential of thallium (I) sulfate in laboratory animals

进行研究以评估硫酸铊 (I) 对实验动物的潜在毒性

• 批准号: 10599058
• 负责人: BARNEY SPARROW
• 金额: $ 42.54万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2023-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10599058
• 关键词: Adverse effects; Chemicals; Data; Development; Dose; Ensure; Environmental Exposure; Evaluation Studies; Exposure to; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Laboratory Animals; Manuscripts; Mission; Mus; Phase; Preparation; Rattus; Risk Assessment; Route; Sulfate; Thallium; Toxic effect; Toxicity Tests; Toxicology; design; disorder prevention; drinking water; exposed human population; neurobehavioral; public health research; reproductive; sound

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of thallium (I) sulfate in rats and mice, following exposure in drinking water. This compound is found in drinking water and thus human exposure is anticipated via this route. In addition, thallium (I) sulfate is likely to be representative of other thallium compounds in drinking water. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of thallium in rats and mice and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. Keywords: toxicity, drinking water, thallium

该项目的目标是支持转化毒理学(DTT)危险识别活动，旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及在饮用水中暴露后对大鼠和小鼠进行硫酸铊(I)的毒性研究。这种化合物是在饮用水中发现的，因此预计人类会通过这一途径接触到这种化合物。此外，硫酸铊(I)很可能是饮用水中其他铊化合物的代表。该项目的数据将用于就铊对大鼠和小鼠的潜在毒性得出合理的科学结论，并最终支持DTT的任务和目标以及其他联邦机构的风险评估活动。 关键词：毒性、饮用水、铊