Binaural processing and hearing in children with cochlear implants
人工耳蜗植入儿童的双耳处理和听力
基本信息
- 批准号:10606930
- 负责人:
- 金额:$ 57.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-12-01 至 2027-11-30
- 项目状态:未结题
- 来源:
- 关键词:AgeAreaAttentionAuditoryAuditory areaBehaviorBilateralBinauralBrainBrain StemChildChildhoodClinicalClinical assessmentsCochlear ImplantsCochlear implant procedureCognitionCognitiveCuesElectrodesElectroencephalographyElectrophysiology (science)EngineeringEnvironmentHearingImplantInvestigationLearningLifeMainstreamingMeasuresMemoryOutcomeParticipantPerformanceResearchRoleSafetySignal TransductionSocializationSpeechStimulusStructureTestingauditory processingbinaural hearingclinical careclinical outcome assessmentcognitive controlcognitive processdeafnessdesignexecutive functionexperienceinsightneuralneurodevelopmentnormal hearingnovelpreservationrecruitsocialstemsuccessvisual tracking
项目摘要
Abstract
There is strong clinical impetus to provide bilateral hearing early in life, not only for safety in navigating the
environment, but also to maximize learning and socializing in mainstreamed settings. Although this topic is an
active area of research, we lack critically important information on how to assess and interpret the impact of age
at onset of deafness and auditory experience in children with bilateral cochlear Implants (CIs). Four groups of
bilateral CI users and normal hearing (NH) participants in the same age ranges will be recruited to test
hypotheses about the role of auditory experience and inter-implant delay in emergence of binaural hearing,
functional listening and cognition. Here we propose novel studies aimed at gaining fresh insight into the role of
auditory experience and inter-implant delay on outcomes. We will integrate perceptual and
electroencephalographical (EEG) measures of binaural integrity (Aim 1), and functional listening with binaural
cues (Aim 2). Further, cognitive measures of executive function (EF) are introduced to promote novel discovery
of the association between binaural listening measures and EF (Aim 3). By synergistically combining these
approaches, this project will be the first to provide urgently needed answers to timely and clinically critical
questions regarding pediatric cochlear implantation. An important barrier to maximizing outcomes stems from
engineering limitations whereby CIs are lacking binaural coordination. In addition, while speech envelope (ENV)
cues are preserved in speech signals, cues that are significant for binaural hearing, namely temporal fine
structure (TFS) cues, are not preserved in CI processing. We will systematically manipulate the control of ENV
and TFS cues by using either research processors that allow exquisite control of timing of stimuli reaching each
electrode or presenting stimuli to clinical processors and in free field, where stimulation is more akin to today’s
CI processing. comprehensive investigation into outcomes in children with bilateral CIs, using perceptual, eye
tracking and EEG measures at multiple levels of auditory processing. The stepwise assessment along the neural
axis, from brainstem to auditory cortex, to cortical connectivity and whole brain coherence analyses, will enable
us to understand which perceptual deficits are associated with abnormal neural processing. Cognitive measures
are introduced to promote novel discovery of how abnormal neural development is related to EF, and if these
effects show pervasive effects beyond auditory-based EF tasks. This information is important for understanding
how the timing of bilateral CIs is related to a set of cognitive processes– regulating attention, memory, and
controlling cognitive behaviors – necessary for success across academic, social, and daily living domains. We
will harness the tests used in our studies to develop a clinical assessment toolbox that can be used by clinicians
to assess binaural hearing abilities, and our findings will further identify which cognitive EF measures should be
use along with auditory measures to clinically assess outcomes in children. Results will inform selection of design
features in engineering CIs, with an emphasis on binaural processors, thus aiming to reduce the gap in
performance relative to NH listeners.
抽象的
在生命早期提供双侧听力有着强大的临床推动力,这不仅是为了安全地导航
环境,同时也最大限度地在主流环境中学习和社交。虽然这个话题是一个
在活跃的研究领域,我们缺乏关于如何评估和解释年龄影响的极其重要的信息
双侧人工耳蜗植入 (CI) 儿童的耳聋发作和听觉体验。四组
将招募相同年龄范围的双边 CI 用户和正常听力(NH)参与者进行测试
关于听觉体验和植入间延迟在双耳听力出现中的作用的假设,
功能性听力和认知。在这里,我们提出新颖的研究,旨在获得新的见解
听觉体验和植入间延迟对结果的影响。我们将感性与
双耳完整性的脑电图 (EEG) 测量(目标 1)以及双耳功能性听力
提示(目标 2)。此外,引入执行功能(EF)的认知测量来促进新的发现
双耳听力测量与 EF 之间的关联(目标 3)。通过协同组合这些
方法,该项目将是第一个为及时和临床关键问题提供急需答案的项目
关于小儿人工耳蜗植入的问题。实现成果最大化的一个重要障碍来自于
CI 缺乏双耳协调的工程限制。此外,虽然语音包络 (ENV)
线索保留在语音信号中,这些线索对双耳听力很重要,即时间精细
CI 处理中不会保留结构 (TFS) 线索。我们将系统地操纵ENV的控制
和 TFS 提示,通过使用任一研究处理器来精确控制到达每个刺激的时间
电极或在自由场中向临床处理器呈现刺激,其中刺激更类似于今天的
CI 处理。使用感知、眼睛对双侧 CI 儿童的结果进行全面调查
听觉处理多个层面的跟踪和脑电图测量。沿着神经网络的逐步评估
从脑干到听觉皮层,再到皮质连接和全脑一致性分析的轴,将使
我们了解哪些知觉缺陷与异常的神经处理有关。认知测量
引入这些新发现是为了促进神经发育异常与 EF 之间的关系的新发现,如果这些
效果显示出超出基于听觉的 EF 任务的普遍效果。此信息对于理解很重要
双侧 CI 的时间安排如何与一组认知过程相关——调节注意力、记忆力和认知能力
控制认知行为——在学术、社交和日常生活领域取得成功所必需的。我们
将利用我们研究中使用的测试来开发可供临床医生使用的临床评估工具箱
评估双耳听力能力,我们的研究结果将进一步确定应采用哪些认知 EF 测量
与听觉测量一起使用来临床评估儿童的结果。结果将告知设计选择
工程 CI 的特点,重点是双耳处理器,从而旨在缩小差距
相对于 NH 听众的表现。
项目成果
期刊论文数量(0)
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Ruth Y Litovsky其他文献
Ruth Y Litovsky的其他文献
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{{ truncateString('Ruth Y Litovsky', 18)}}的其他基金
Improving Binaural Hearing in Children with Cochlear Implants
改善植入人工耳蜗儿童的双耳听力
- 批准号:
8827879 - 财政年份:2014
- 资助金额:
$ 57.47万 - 项目类别:
Spatial Hearing in Children with Normal Hearing and Bilateral Cochlear Implants
听力正常且双侧人工耳蜗植入儿童的空间听力
- 批准号:
7857943 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
Improving Binaural Hearing in Children with Cochlear Implants
改善植入人工耳蜗儿童的双耳听力
- 批准号:
8763932 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
Spatial Hearing in Children with Normal Hearing and Bilateral Cochlear Implants
听力正常且双侧人工耳蜗植入儿童的空间听力
- 批准号:
7628035 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
Spatial Hearing in Children with Normal Hearing and Bilateral Cochlear Implants
听力正常且双侧人工耳蜗植入儿童的空间听力
- 批准号:
7753770 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
Spatial Hearing in Children with Normal Hearing and Bilateral Cochlear Implants
听力正常且双侧人工耳蜗植入儿童的空间听力
- 批准号:
7322567 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
Spatial Hearing in Children with Normal Hearing and Bilateral Cochlear Implants
听力正常且双侧人工耳蜗植入儿童的空间听力
- 批准号:
7462298 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
Improving Binaural Hearing in Children with Cochlear Implants
改善植入人工耳蜗儿童的双耳听力
- 批准号:
8630807 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
Spatial Hearing in Children with Normal Hearing and Bilateral Cochlear Implants
听力正常且双侧人工耳蜗植入儿童的空间听力
- 批准号:
7633094 - 财政年份:2007
- 资助金额:
$ 57.47万 - 项目类别:
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