Tau Burden and Spatial Spread in Preclinical Alzheimer Disease

临床前阿尔茨海默病中的 Tau 蛋白负担和空间扩散

• 批准号: 10606646
• 负责人: JOHN MORRIS
• 金额: $ 180.29万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10606646
• 关键词: Address; Adult Children; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer’s disease biomarker; Amyloid; Amyloid Proteins; Amyloid beta-Protein; Amyloidosis; Blood; Blood Pressure; Blood Vessels; Body mass index; Brain; Brain Mapping; Cerebrospinal Fluid; Cerebrovascular Disorders; Cerebrum; Clinical; Cognitive; Data; Dementia; Deposition; Development; Diet; Diffusion Magnetic Resonance Imaging; Elderly; Evaluation; Exercise; Functional Magnetic Resonance Imaging; Genetic; Glycosylated hemoglobin A; Goals; Grant; Hemorrhage; Image; Imaging Techniques; Impaired cognition; Impairment; Individual; Infarction; Inflammation; Lead; Life Style; Link; Longevity; Magnetic Resonance Imaging; Maps; Measures; Medial; Nerve Degeneration; Normalcy; Participant; Pathology; Pathway interactions; Pattern; Phase; Phenotype; Physical activity; Physiology; Pittsburgh Compound-B; Positron-Emission Tomography; Program Research Project Grants; Race; Rest; Risk; Staging; Symptoms; Tauopathies; Temporal Lobe; Testing; Thick; White Matter Disease; White Matter Hyperintensity; abeta deposition; beta amyloid pathology; cardiovascular health; cerebrovascular lesion; cognitive performance; gut microbiome; imaging biomarker; imaging modality; molecular marker; nerve injury; neural; neuroinflammation; neuropathology; pre-clinical; radioligand; serial imaging; sex; social health determinants; social influence; tau Proteins; tau aggregation; uptake; white matter; β-amyloid burden

Project 1: Project Summary/Abstract The Adult Children Study (ACS) is an ongoing evaluation of middle to older adults at risk for development of Alzheimer disease (AD). In Project 1 of the ACS, we use a combination of advanced imaging techniques to explore the earliest signs of AD pathology. Using positron emission tomography (PET) we test for amyloid and tau protein deposits in the brain, using Pittsburgh Compound B C11 (PiB) and Flortaucipir F18 (FTP) and we examine brain structural networks, pathology and physiology using magnetic resonance imaging (MRI). While amyloid deposits can be present up to 20 years before dementia symptoms, tau deposits are closely linked with cognitive decline. We will evaluate the structural and functional changes in the brain associated with the transition from the asymptomatic (preclinical) phase of AD into the symptomatic stages of AD dementia. We will generate unique brain maps for each imaging modality and we will then examine these maps in relation to one another, to develop an integrated understanding of the imaging changes which occur during the transition from asymptomatic and symptomatic AD. We will combine this information with information about lifestyle, exercise, diet, inflammation, and blood and cerebrospinal fluid (CSF) tests obtained in the other ACS Cores and Projects in order to better understand what factors lead to AD dementia.

项目1：项目摘要/摘要 成人儿童研究(ACS)是对有发展风险的中老年人进行的持续评估 阿尔茨海默病(AD)。在ACS的项目1中，我们使用高级成像技术的组合来 探索AD病理的最早征象。使用正电子发射断层扫描(PET)，我们检测淀粉样蛋白和 Tau蛋白在大脑中沉积，使用匹兹堡化合物B C11(PIB)和Flortaucipir F18(FTP)和WE 使用磁共振成像(MRI)检查脑结构网络结构、病理和生理学。而当 淀粉样蛋白沉积可在痴呆症症状出现前20年出现，tau沉积与此密切相关 认知能力下降。我们将评估与此相关的大脑结构和功能变化 从AD的无症状(临床前)阶段过渡到AD痴呆的症状阶段。我们 将为每种成像模式生成唯一的脑图，然后我们将检查这些图与 以发展对在过渡期间发生的成像变化的综合理解 来自无症状和有症状的阿尔茨海默病。我们将把这些信息与生活方式的信息结合起来， 在其他ACS核心中进行运动、饮食、炎症以及血液和脑脊液(CSF)测试 和项目，以更好地了解是什么因素导致阿尔茨海默病。