Excitation and inhibition in visual processing

视觉处理中的兴奋和抑制

• 批准号: 10615072
• 负责人: Nicholas J Priebe
• 金额: $ 50.62万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615072
• 关键词: Address; Afferent Neurons; Animal Behavior; Architecture; Area; Autopsy; Behavior; Behavioral; Biological Models; Calcium; Callithrix; Cells; Complex; Cues; Disparate; Electrophysiology (science); Elements; Environment; Esthesia; Eye Movements; Genomics; Goals; Image; Individual; Injections; Knowledge; Label; Location; Measurement; Measures; Membrane Potentials; Modeling; Motion; Nature; Neurons; Neurosciences; Pattern; Physiological; Population; Primates; Process; Property; Role; Sensory; Shapes; Signal Transduction; Stimulus; System; Testing; V1 neuron; Viral; Visual; Visual Cortex; Visual Motion; Visual System; Work; area MT; experimental study; extracellular; immunocytochemistry; neural; neural circuit; neurochemistry; novel; object motion; orientation selectivity; response; sensory input; sensory integration; sensory mechanism; sensory system; two photon microscopy; visual processing

Project Summary A fundamental goal of systems neuroscience is to describe how sensory inputs are integrated and guide an animal's behavior. To be able to integrate these inputs, early sensory systems have developed selectivities for specific stimulus features that allow them to analyze the inputs using these features as basis. A classic example is the emergence of orientation selectivity within the visual cortex (Hubel and Wiesel, 1962). Successive processing stages in the early visual system perform systematic transformations on the incoming inputs that enable them to be able to identify multiple aspects of the visual scene important for guiding an animal's behavior, including the location, shape, depth and motion of objects. While the unique feature selectivities emerging at different stages in visual processing are known to a certain extent, the nature and mechanisms of these sensory transformations less well-understood. We aim to uncover how disparate motion signals are integrated to produce a global percept of motion, and to understand the conditions in which such integration fails.

项目摘要 系统神经科学的一个基本目标是描述感觉输入是如何整合的， 引导动物的行为。为了能够整合这些输入，早期的感觉系统 开发了特定刺激特征的选择性，使他们能够使用这些特征分析输入， 特征为基础。一个经典的例子是视觉中出现的方向选择性 皮质（Hubel和Wielton，1962）。早期视觉系统中的连续处理阶段 对输入的系统转换，使他们能够识别多个 对指导动物行为很重要的视觉场景方面，包括位置，形状， 物体的深度和运动。虽然在不同阶段出现的独特功能选择性， 视觉处理在一定程度上是已知的，这些感觉的性质和机制 不太容易理解的变化。我们的目标是揭示不同的运动信号是如何 综合起来，产生一个全球性的运动感知，并了解这种运动的条件， 整合失败。

项目成果

Orientation selectivity of synaptic input to neurons in mouse and cat primary visual cortex.

• DOI: 10.1523/jneurosci.2039-11.2011
• 发表时间: 2011-08-24
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Tan AY;Brown BD;Scholl B;Mohanty D;Priebe NJ
• 通讯作者: Priebe NJ

On the Rotations of the Cranial Spheres.

关于颅球的旋转。

• DOI: 10.1016/j.neuron.2020.10.030
• 发表时间: 2020
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Pattadkal,JagrutiJ;Priebe,NicholasJ
• 通讯作者: Priebe,NicholasJ

Functional characterization of spikelet activity in the primary visual cortex.

初级视觉皮层小穗活动的功能特征。

• DOI: 10.1113/jp270876
• 发表时间: 2015
• 期刊: The Journal of physiology
• 作者: Scholl,Benjamin;Andoni,Sari;Priebe,NicholasJ
• 通讯作者: Priebe,NicholasJ

Natural binocular depth discrimination behavior in mice explained by visual cortical activity.

• DOI: 10.1016/j.cub.2021.02.031
• 发表时间: 2021-05-24
• 期刊: Current biology : CB
• 作者: Boone HC;Samonds JM;Crouse EC;Barr C;Priebe NJ;McGee AW
• 通讯作者: McGee AW

Functional characterization and spatial clustering of visual cortical neurons in the predatory grasshopper mouse Onychomys arenicola.

捕食性蚱蜢小鼠甲鼠视觉皮层神经元的功能特征和空间聚类。

• DOI: 10.1152/jn.00779.2016
• 发表时间: 2017
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Scholl,Benjamin;Pattadkal,JagrutiJ;Rowe,Ashlee;Priebe,NicholasJ
• 通讯作者: Priebe,NicholasJ