Southeast Asia Malaria Research Center

东南亚疟疾研究中心

• 批准号: 10612378
• 负责人: LIWANG CUI
• 金额: $ 233.63万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10612378
• 关键词: Achievement; Address; Affect; Anti-malarial drug resistance; Antibodies; Artemisinins; Behavioral; Biological Assay; Biology; Biostatistics Core; Bite; Breeding; Cambodia; China; Chloroquine resistance; Circulation; Collaborations; Combined Modality Therapy; Communities; Complex; Country; Culicidae; Development; Disease; Drug resistance; Ecology; Effectiveness; Epidemiological trend; Epidemiology; Face; Falciparum Malaria; Family; Fostering; Foundations; Genomics; Goals; Heterogeneity; Human; Immunoassay; Individual; Insecticide Resistance; Insecticides; International; Intervention; Knowledge; Laos; Malaria; Measures; Migrant; Molecular; Monitor; Monoclonal Antibodies; Multi-Drug Resistance; Myanmar; Parasite resistance; Parasites; Persons; Pharmaceutical Preparations; Phase; Plasmodium falciparum; Plasmodium vivax; Politics; Population; Population Biology; Porosity; Province; Public Health; Pyrimethamine; Research; Resistance; Sampling; Scientist; Series; Site; Southeastern Asia; Structure; System; Thailand; United States; Vietnam; Vivax Malaria; data management; detection assay; effectiveness evaluation; environmental change; human migration; improved; innovation; innovative technologies; interdisciplinary approach; malaria transmission; new combination therapies; point of care; programs; resistance mechanism; resistant Plasmodium falciparum; socioeconomic development; southeast Asian; transmission process; vector; vector control; vector mosquito

OVERALL SUMMARY Malaria in the Greater Mekong Subregion (GMS) of Southeast Asia remains an important public health problem. There is immense spatial heterogeneity in malaria distribution, with Myanmar having the highest regional malaria burden. Highly mobile populations crossing porous international borders are a major contributor to parasite introduction and continued transmission. The recent emergence of resistance to the artemisinin (ART) family of drugs as well as to their partner drugs raised global concerns. The vectorial system is highly diverse, and increased outdoor biting and development of insecticide resistance have rendered the two core vector control interventions – insecticide-treated nets and indoor residue spray less effective. Furthermore, falsified and substandard ART-based combination therapies (ACTs) have become a global crisis. Therefore, the central goal of this program is to improve our understanding of how mobile human populations, parasite drug resistance, and mosquito biology contribute to continuous malaria transmission at international borders so that innovative control strategies can be developed to propel the course of regional malaria elimination. To achieve this overarching objective, we have selected study sites in the international border regions of three GMS countries, Myanmar, China, and Thailand, with drastically different malaria epidemiology to conduct comprehensive research on humans, vectors, and parasites in four interrelated projects. In Project 1, the foundation of the whole program, we will conduct malaria surveillance, monitor human migration and its impact on parasite introduction, and evaluate the effectiveness of the current treatment of the predominant P. vivax malaria. Project 2 will study how environmental changes affect mosquito community structures and malaria transmission, identify whether behavioral changes of major vectors are genetically determined, and determine the extent and mechanisms of insecticide resistance in malaria vectors. In Project 3, we will address the emerging problem of resistance of P. falciparum to both the ART family of drugs and partner drugs through molecular studies of resistance mechanisms and by tracking resistance spread in the GMS. Finally, we want to develop monoclonal antibody-based immunoassays to detect both active ingredients in an ACT, and use our newly developed point-of-care dipstick assays for large-scale assessment of the extent of problem of the falsified and substandard ACTs in the GMS countries using a stratified random sampling approach. This program, built on the scientific achievements of the current ICEMR program and the strong network of international collaborators, aims to dissect the complex interactions between migrant human populations, diverse mosquito vectors, MDR parasites, and falsified and substandard ACTs, which are responsible for continued malaria transmission along international borders. These scientific questions are not only pertinent to the GMS nations, but are also applicable to other malaria regions. Therefore, findings from these studies will bear far-reaching impacts on global malaria elimination.

整体总结

项目成果

Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007-2012.

• DOI: 10.1186/s12936-015-0672-9
• 发表时间: 2015-04-18
• 期刊: Malaria journal
• 影响因子: 3
• 作者: Wang Z;Shrestha S;Li X;Miao J;Yuan L;Cabrera M;Grube C;Yang Z;Cui L
• 通讯作者: Cui L

Prevalence of asymptomatic Plasmodium infections with sub-microscopic parasite densities in the northwestern border of Thailand: a potential threat to malaria elimination.

• DOI: 10.1186/s12936-018-2476-1
• 发表时间: 2018-09-12
• 期刊: Malaria journal
• 影响因子: 3
• 作者: Sattabongkot J;Suansomjit C;Nguitragool W;Sirichaisinthop J;Warit S;Tiensuwan M;Buates S
• 通讯作者: Buates S

Development of a specific monoclonal antibody-based ELISA to measure the artemether content of antimalarial drugs.

• DOI: 10.1371/journal.pone.0079154
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Guo S;Cui Y;He L;Zhang L;Cao Z;Zhang W;Zhang R;Tan G;Wang B;Cui L
• 通讯作者: Cui L

In vitro sensitivity of Plasmodium falciparum from China-Myanmar border area to major ACT drugs and polymorphisms in potential target genes.

中缅边境地区恶性疟原虫对主要ACT药物的体外敏感性及潜在靶基因多态性

• DOI: 10.1371/journal.pone.0030927
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Wang Z;Parker D;Meng H;Wu L;Li J;Zhao Z;Zhang R;Miao M;Fan Q;Wang H;Cui L;Yang Z
• 通讯作者: Yang Z

Efficacy of directly-observed chloroquine-primaquine treatment for uncomplicated acute Plasmodium vivax malaria in northeast Myanmar: A prospective open-label efficacy trial.

• DOI: 10.1016/j.tmaid.2019.101499
• 发表时间: 2020-07
• 期刊: Travel medicine and infectious disease
• 影响因子: 12
• 作者: Xu S;Zeng W;Ngassa Mbenda HG;Liu H;Chen X;Xiang Z;Li C;Zhang Y;Baird JK;Yang Z;Cui L
• 通讯作者: Cui L