Universal GABA-edited MRS at 3T

描述(由申请人提供)：抑制性神经递质GABA在兴奋性神经元活动的控制和调节中起着核心作用。使用编辑的~1H磁共振波谱(MRS)可以非侵入性地检测GABA。到目前为止，这种方法在很大程度上局限于那些具有本地MRS专业知识的站点，而且不同的实施方式使得站点之间的结果难以比较。这笔赠款的总体目标是开发一种通用的采集和处理管道，用于测量人脑中的GABA浓度。我们将为3T的大分子抑制的GABA编辑的MRS开发一个在所有三个主要供应商平台上实施的单一序列，用于定量数据分析，并展示新测量的跨平台等价性。由此产生的数据获取和分析工具将提供给临床神经科学和神经成像界。

DESCRIPTION (provided by applicant): The inhibitory neurotransmitter GABA has a central role in control and tuning of excitatory neuronal activity. GABA can be detected non-invasively using edited 1H magnetic resonance spectroscopy (MRS). Until now, this methodology has largely been confined to those sites that have local MRS expertise, and different implementations make comparison of results between site difficult. The overall goal of this grant is the development of a universal acquisition and processing pipeline for measuring GABA concentration in the human brain. We will develop a single sequence, implemented on all three major vendor platforms, for the macromolecule-suppressed GABA-edited MRS at 3T, the GABA Analysis Toolkit (Gannet) for quantitative data analysis, and demonstrate the cross-platform equivalence of the new measurement. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.