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Universal GABA-edited MRS at 3T

3T 通用 GABA 编辑 MRS

基本信息

批准号：
8577507
负责人：
Richard Anthony Edward Edden
金额：
$ 38.04万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8577507
关键词：
Accounting Address Anterior Brain Brain Diseases Brain region Chemicals Clinical Collaborations Communities Computer software Concentration measurement Data Analyses Databases Development Disease Frequencies Functional disorder Goals Grant Human Individual Location Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Manufacturer Name Measurement Measures Methodology Methods Metric Motion Neurons Neurosciences Neurotransmitters Output Phase Process Publishing Relative (related person)Relaxation Research Research Personnel Role Scanning Signal Transduction Site Solutions Spectrum Analysis Standardization Techniques Technology Three-Dimensional Image Time Uncertainty Vendor Visual awake base cohort computerized data processing data acquisition data format design gamma-Aminobutyric Acid healthy volunteer human subject in vivo interest macromolecule neuroimaging prevent software development tool uptake user-friendly

项目摘要

DESCRIPTION (provided by applicant): The inhibitory neurotransmitter GABA has a central role in control and tuning of excitatory neuronal activity. GABA can be detected non-invasively using edited 1H magnetic resonance spectroscopy (MRS). Until now, this methodology has largely been confined to those sites that have local MRS expertise, and different implementations make comparison of results between site difficult. The overall goal of this grant is the development of a universal acquisition and processing pipeline for measuring GABA concentration in the human brain. We will develop a single sequence, implemented on all three major vendor platforms, for the macromolecule-suppressed GABA-edited MRS at 3T, the GABA Analysis Toolkit (Gannet) for quantitative data analysis, and demonstrate the cross-platform equivalence of the new measurement. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

描述（由申请人提供）：抑制性神经递质GABA在兴奋性神经元活动的控制和调谐中具有核心作用。GABA可以使用编辑的1H磁共振波谱（MRS）进行非侵入性检测。到目前为止，这种方法在很大程度上仅限于那些具有本地MRS专业知识的站点，并且不同的实施方式使得站点之间的结果比较困难。这项资助的总体目标是开发一种通用的采集和处理管道，用于测量人脑中GABA的浓度。我们将开发一个单一序列，在所有三个主要供应商平台上实施，用于在3T下的大分子抑制GABA编辑的MRS，用于定量数据分析的GABA分析工具包（Gannet），并证明新测量的跨平台等效性。由此产生的数据采集和分析工具将分发给临床神经科学和神经影像学界。