Program in Biomedical Sciences

生物医学科学项目

• 批准号: 10620792
• 负责人: AMANDA K MCCULLOUGH
• 金额: $ 53.05万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620792
• 关键词: Science; programs

The Program in Biomedical Sciences (PBMS) is a new degree-granting interdisciplinary program designed to provide rigorous training in molecular, biochemical and cellular biology for trainees pursing a career in research-related disciplines. It replaces our prior NIGMS-funded program with substaintial curricular reform designed to meet the needs of the current biomedical research workforce. PBMS provides high quality didactic training that includes scientific content interwoven with elements that enhance the development of professional skills and ensures the highest standard of research training. PBMS is comprised of six research hubs focused on 1) Biochemical, Molecular and Structural Biology; 2) Chemical Physiology; 3) Differentiation, Development and Disease, 4) Genome Sciences; 5) Integrated Cancer Biology; 6) Infectious Disease and Immunology. These hubs provide intensive academic environments that are reflective of research strengths at OHSU and facilitate the training needs of our diverse group of students. Hubs are populated by highly dedicated faculty and trainees at all levels to create inspiring research training opportunites. The mission of PBMS is to train students from a diversity of personal backgrounds and biomedical disciplines so they are prepared to successfully enter the biomedical research workforce. Associated with PBMS is this proposed T32 program, which is fully integrated into the PBMS structure. It brings added value through new experiential learning and career development opportunites, and creating a growing cohort that fosters inclusiveness. The overarching objective is to provide high-quality research training and facilitate transition into a variety of potential careers. This is supported by curricular reform that includes mentored research experiences, interdisciplinary scientific research training, experiential professional training, and an environment that enhances opportunities for collaborative work. The objectives of the program are: 1) Provide trainees with the specific skills they need to successfully enter the biomedical workforce in the field of their choosing. This includes activities that inform students about career opportunities, how to prepare for their career choice, and networking opportunities to facilitate career entry; 2) Enhance the training environment to become more inclusive and supportive, with the goal of building and sustaining diversity at all levels in our program; 3) Expand the highly collaborative nature of our research enterprise by encouraging trainee involvement in identifying and participating in new collaborations; 4) Reduce time to completion from the current average 5.6 years to 4.5 years, which is addressed by substantial curricular reform; 5) Increase the completion rate for all trainees. In the past 5-years 98% of well-represented trainees but only 85% from underrepresented groups completed the PhD. Improved retention is based on efforts to build a more inclusive training environment that supports and values diversity at all levels. Trainees from this program will enter the biomedical research workforce with the expertise in a basic biomedical discipline and skills to independently acquire knowledge to advance their chosen field.

生物医学科学计划（PBMS）是一个新的学位跨学科计划 为受训者提供严格的分子，生化和细胞生物学培训，从事职业 与研究有关的学科。它用代理课程改革取代了我们先前的NIGMS资助计划 旨在满足当前生物医学研究人员的需求。 PBM提供高质量的教学 培训包括与科学内容相互交织的元素，以增强专业的发展 技能和确保研究培训的最高标准。 PBM由六个研究中心组成 1）生化，分子和结构生物学； 2）化学生理学； 3）分化，发展 和疾病，4）基因组科学； 5）综合癌症生物学； 6）传染病和免疫学。 这些枢纽提供了密集的学术环境，这些学术环境反映了OHSU和 促进我们多样化的学生的培训需求。集线器由高度专用的教师填充 和各个级别的学员创造了鼓舞人心的研究培训机会。 PBM的任务是训练 来自各种各样的个人背景和生物医学学科的学生，因此他们准备好 成功进入生物医学研究人员。与PBM相关的是该提出的T32程序， 完全集成到PBMS结构中。它通过新的体验学习和 职业发展的机会，并创造了促进包容性的越来越多的队列。总体 目的是提供高质量的研究培训，并促进过渡到各种潜在职业。 这是课程改革的支持，包括指导的研究经验，跨学科科学 研究培训，体验式专业培训以及增强机会的环境 协作工作。该计划的目标是：1）为受训人员提供所需的特定技能 成功地进入他们选择的领域的生物医学劳动力。这包括通知的活动 学生涉及职业机会，如何为自己的职业选择做准备以及网络机会 促进职业进入； 2）增强培训环境，以变得更加包容和支持 在我们计划中建立和维持多样性的目标； 3）扩大高度协作的性质 通过鼓励学员参与识别和参与新的研究，我们的研究企业 合作； 4）将完成的时间从当前的平均5.6岁降低到4。5年，即 通过实质性的课程改革解决； 5）提高所有学员的完成率。在过去的五年中 代表性良好的学员中，有98％的人数只有85％的人为群体完成了博士学位。改进 保留是基于建立更具包容性培训环境的努力，以支持和价值多样性 所有级别。该计划的学员将进入基本的专业知识的生物医学研究人员 生物医学纪律和技能独立获取知识以推进其选择的领域。

项目成果

Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology.

• DOI: 10.3389/fphar.2022.925880
• 发表时间: 2022
• 期刊: FRONTIERS IN PHARMACOLOGY
• 影响因子: 5.6
• 作者: Oken, Adam C.;Krishnamurthy, Ipsita;Savage, Jonathan C.;Lisi, Nicolas E.;Godsey, Michael H.;Mansoor, Steven E.
• 通讯作者: Mansoor, Steven E.

Cancer stem cell-derived extracellular vesicles preferentially target MHC-II-macrophages and PD1+ T cells in the tumor microenvironment.

• DOI: 10.1371/journal.pone.0279400
• 发表时间: 2023
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Gonzalez-Callejo, Patricia;Guo, Zihan;Ziglari, Tahereh;Claudio, Natalie Marcia;Nguyen, Kayla Hoang;Oshimori, Naoki;Seras-Franzoso, Joaquim;Pucci, Ferdinando
• 通讯作者: Pucci, Ferdinando

Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo.

• DOI: 10.1038/s41467-022-35097-5
• 发表时间: 2022-11-30
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Tiyaboonchai, Amita;Vonada, Anne;Posey, Jeffrey;Pelz, Carl;Wakefield, Leslie;Grompe, Markus
• 通讯作者: Grompe, Markus

Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility.

• DOI: 10.1016/j.crmeth.2023.100625
• 发表时间: 2023-11-20
• 期刊: Cell reports methods
• 作者: Queitsch K;Moore TW;O'Connell BL;Nichols RV;Muschler JL;Keith D;Lopez C;Sears RC;Mills GB;Yardımcı GG;Adey AC
• 通讯作者: Adey AC

Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity.

• DOI: 10.1038/s41598-022-08655-6
• 发表时间: 2022-03-23
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Pincus AB;Huang SJ;Lebold KM;De La Torre U;Proskocil BJ;Drake MG;Nakai H;Fryer AD;Jacoby DB
• 通讯作者: Jacoby DB