Program in Biomedical Sciences

生物医学科学项目

• 批准号: 10620792
• 负责人: AMANDA K MCCULLOUGH
• 金额: $ 53.05万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620792
• 关键词: Science; programs

The Program in Biomedical Sciences (PBMS) is a new degree-granting interdisciplinary program designed to provide rigorous training in molecular, biochemical and cellular biology for trainees pursing a career in research-related disciplines. It replaces our prior NIGMS-funded program with substaintial curricular reform designed to meet the needs of the current biomedical research workforce. PBMS provides high quality didactic training that includes scientific content interwoven with elements that enhance the development of professional skills and ensures the highest standard of research training. PBMS is comprised of six research hubs focused on 1) Biochemical, Molecular and Structural Biology; 2) Chemical Physiology; 3) Differentiation, Development and Disease, 4) Genome Sciences; 5) Integrated Cancer Biology; 6) Infectious Disease and Immunology. These hubs provide intensive academic environments that are reflective of research strengths at OHSU and facilitate the training needs of our diverse group of students. Hubs are populated by highly dedicated faculty and trainees at all levels to create inspiring research training opportunites. The mission of PBMS is to train students from a diversity of personal backgrounds and biomedical disciplines so they are prepared to successfully enter the biomedical research workforce. Associated with PBMS is this proposed T32 program, which is fully integrated into the PBMS structure. It brings added value through new experiential learning and career development opportunites, and creating a growing cohort that fosters inclusiveness. The overarching objective is to provide high-quality research training and facilitate transition into a variety of potential careers. This is supported by curricular reform that includes mentored research experiences, interdisciplinary scientific research training, experiential professional training, and an environment that enhances opportunities for collaborative work. The objectives of the program are: 1) Provide trainees with the specific skills they need to successfully enter the biomedical workforce in the field of their choosing. This includes activities that inform students about career opportunities, how to prepare for their career choice, and networking opportunities to facilitate career entry; 2) Enhance the training environment to become more inclusive and supportive, with the goal of building and sustaining diversity at all levels in our program; 3) Expand the highly collaborative nature of our research enterprise by encouraging trainee involvement in identifying and participating in new collaborations; 4) Reduce time to completion from the current average 5.6 years to 4.5 years, which is addressed by substantial curricular reform; 5) Increase the completion rate for all trainees. In the past 5-years 98% of well-represented trainees but only 85% from underrepresented groups completed the PhD. Improved retention is based on efforts to build a more inclusive training environment that supports and values diversity at all levels. Trainees from this program will enter the biomedical research workforce with the expertise in a basic biomedical discipline and skills to independently acquire knowledge to advance their chosen field.

生物医学科学计划（PBMS）是一个新的学位授予跨学科计划，旨在 提供严格的分子，生物化学和细胞生物学培训，为学员追求职业生涯， 研究相关学科。它取代了我们以前的NIGMS资助的计划与实质性的课程改革 旨在满足当前生物医学研究人员的需求。PBMS提供高质量的教学 培训内容包括科学内容，并与促进专业发展的要素交织在一起， 技能，并确保最高标准的研究培训。PBMS由六个研究中心组成， 1）生物化学，分子和结构生物学; 2）化学生理学; 3）分化，发育 4）基因组科学; 5）综合癌症生物学; 6）传染病和免疫学。 这些中心提供密集的学术环境，反映了OHSU的研究优势， 促进我们不同学生群体的培训需求。中心由高度敬业的教师组成 和各级学员，创造鼓舞人心的研究培训机会。PBMS的使命是培训 来自不同个人背景和生物医学学科的学生，因此他们准备 成功进入生物医学研究队伍。与PBMS相关的是这个拟议的T32计划， 该系统完全集成到PBMS结构中。它通过新的体验式学习带来附加值， 职业发展机会，并创造一个不断增长的群体，促进包容性。总体 目标是提供高质量的研究培训，并促进过渡到各种潜在的职业。 这得到了课程改革的支持，课程改革包括指导研究经验、跨学科科学知识、 研究培训，体验式专业培训，以及提高机会的环境， 协同工作。该计划的目标是：1）为学员提供他们需要的具体技能， 成功进入他们选择的领域的生物医学劳动力。这包括提供信息的活动 学生关于职业机会，如何为他们的职业选择做准备，以及网络机会， 促进职业入门; 2）改善培训环境，使其更具包容性和支持性， 在我们的计划中建立和维持各级多样性的目标; 3）扩大高度协作的性质 我们的研究企业，鼓励学员参与识别和参与新的 4）将完成时间从目前的平均5.6年缩短到4.5年， 通过实质性的课程改革来解决; 5）提高所有受训人员的完成率。在过去的5年里， 98%的代表性良好的学员，但只有85%的代表性不足的群体完成了博士学位。改进 保留是基于努力建立一个更具包容性的培训环境，支持和重视多样性， 各级从这个计划的学员将进入生物医学研究的劳动力与专业知识的基本 生物医学学科和技能，独立获取知识，以推进他们所选择的领域。

项目成果

Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology.

• DOI: 10.3389/fphar.2022.925880
• 发表时间: 2022
• 期刊: FRONTIERS IN PHARMACOLOGY
• 影响因子: 5.6
• 作者: Oken, Adam C.;Krishnamurthy, Ipsita;Savage, Jonathan C.;Lisi, Nicolas E.;Godsey, Michael H.;Mansoor, Steven E.
• 通讯作者: Mansoor, Steven E.

Cancer stem cell-derived extracellular vesicles preferentially target MHC-II-macrophages and PD1+ T cells in the tumor microenvironment.

• DOI: 10.1371/journal.pone.0279400
• 发表时间: 2023
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Gonzalez-Callejo, Patricia;Guo, Zihan;Ziglari, Tahereh;Claudio, Natalie Marcia;Nguyen, Kayla Hoang;Oshimori, Naoki;Seras-Franzoso, Joaquim;Pucci, Ferdinando
• 通讯作者: Pucci, Ferdinando

Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo.

• DOI: 10.1038/s41467-022-35097-5
• 发表时间: 2022-11-30
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Tiyaboonchai, Amita;Vonada, Anne;Posey, Jeffrey;Pelz, Carl;Wakefield, Leslie;Grompe, Markus
• 通讯作者: Grompe, Markus

Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility.

可访问的高通量单细胞全基因组测序，配对染色质可及性。

• DOI: 10.1016/j.crmeth.2023.100625
• 发表时间: 2023-11-20
• 期刊: Cell reports methods
• 作者: Queitsch K;Moore TW;O'Connell BL;Nichols RV;Muschler JL;Keith D;Lopez C;Sears RC;Mills GB;Yardımcı GG;Adey AC
• 通讯作者: Adey AC

Multicolor labeling of airway neurons and analysis of parasympathetic heterogeneity.

• DOI: 10.1038/s41598-022-08655-6
• 发表时间: 2022-03-23
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Pincus AB;Huang SJ;Lebold KM;De La Torre U;Proskocil BJ;Drake MG;Nakai H;Fryer AD;Jacoby DB
• 通讯作者: Jacoby DB