Novel Transcriptional Regulation in Skeletal Muscle Development and Disease
骨骼肌发育和疾病中的新转录调控
基本信息
- 批准号:nhmrc : 112902
- 负责人:
- 金额:$ 22.98万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:NHMRC Project Grants
- 财政年份:2000
- 资助国家:澳大利亚
- 起止时间:2000-01-01 至 2002-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It has been assumed that once genes are activated in a particular type of cell, they remain 'on'. From work described in this laboratory, we now know that gene activity may come and go. Instead of the analogy of a light switch that has been turned on and stays on, it appears that at least in muscle, gene activity is more like blinking lights. If you take an image of muscle tissue, which is just a snapshot in time, a gene may not appear to be activated if it was temporarily 'flashing off' at the time of viewing. This may occur in all tissue types, but it is more easily detected in muscle because the cell is large with many nuclei, rather than small with a single nucleus. Another reason why this phenomenon is more readily detectable in muscle cells is that they are very dynamic cells that can undergo fairly radical changes in shape. An actively growing or hypertrophying muscle cell may have all of its genes at a high pitch of transcriptional activity to support rapid growth. However, once a muscle cell has reached its appropriate size, then muscle genes switch to a flashing mode of transcription to maintain rather than build structures. SIGNIFICANCE: (1) This may be a fundamental mechanism of gene regulation that occurs in virtually all cell types. As such, our finding will open an area of research into the types of molecules involved in this novel mechanism. (2) Our studies will result in a better understanding of the mechanisms of muscle cell hypertrophy in response to excercise and drugs, as well as atrophy due to nerve damage or inherited muscle disease. (3) This mechanism may explain the expression of foreign DNA in muscle cells delivered via gene therapy approaches. Our findings could result in a more efficacious means of expressing the introduced gene that might require tricking the muscle fibre into believing that it is in a perpetual growth mode.
人们一直认为,一旦某种特定类型的细胞中的基因被激活,它们就会保持“开启”状态。从这个实验室描述的工作中,我们现在知道基因活动可能会出现和消失。与打开并保持打开状态的灯开关相比,至少在肌肉中,基因活动似乎更像是闪烁的灯。如果你拍摄肌肉组织的图像,这只是一个时间快照,那么如果一个基因在观看时暂时“闪烁”,那么它可能不会被激活。这可能发生在所有组织类型中,但在肌肉中更容易检测到,因为肌肉细胞大而多核,而不是小而单核。这种现象在肌肉细胞中更容易被发现的另一个原因是,肌肉细胞是非常动态的细胞,可以经历相当彻底的形状变化。一个活跃生长或肥大的肌肉细胞可能所有的基因都处于高水平的转录活动,以支持快速生长。然而,一旦肌肉细胞达到适当的大小,肌肉基因就会切换到一种闪烁的转录模式,以维持而不是构建结构。意义:(1)这可能是几乎所有细胞类型中发生的基因调控的基本机制。因此,我们的发现将为研究这种新机制所涉及的分子类型开辟一个领域。(2)我们的研究将有助于更好地理解运动和药物引起的肌肉细胞肥大,以及神经损伤或遗传性肌肉疾病引起的肌肉萎缩的机制。(3)这一机制可以解释外源DNA通过基因治疗途径在肌肉细胞中的表达。我们的发现可能会导致一种更有效的方式来表达引入的基因,这可能需要欺骗肌肉纤维,使其相信自己处于永久生长模式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Prof Edna Hardeman其他文献
Prof Edna Hardeman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Prof Edna Hardeman', 18)}}的其他基金
Single molecule intracellular intravital imaging of actin dynamics
肌动蛋白动力学的单分子细胞内活体成像
- 批准号:
DP160101623 - 财政年份:2016
- 资助金额:
$ 22.98万 - 项目类别:
Discovery Projects
Molecular Dissection of the Actin Cytoskeleton in Exocytosis Using Intravital Microscopy
使用活体显微镜对胞吐作用中肌动蛋白细胞骨架进行分子解剖
- 批准号:
nhmrc : 1079866 - 财政年份:2015
- 资助金额:
$ 22.98万 - 项目类别:
Project Grants
Mouse models for the identification of factors involved in muscle adaptation
用于识别肌肉适应因素的小鼠模型
- 批准号:
DP0984430 - 财政年份:2009
- 资助金额:
$ 22.98万 - 项目类别:
Discovery Projects
Novel features and mechanisms of congenital myopathies
先天性肌病的新特征和机制
- 批准号:
nhmrc : 321701 - 财政年份:2005
- 资助金额:
$ 22.98万 - 项目类别:
NHMRC Project Grants
THE ROLES OF CYTOSKELETAL PROTEINS IN SKELETAL MUSCLE FUNCTION AND DISEASE
细胞骨架蛋白在骨骼肌功能和疾病中的作用
- 批准号:
nhmrc : 185206 - 财政年份:2002
- 资助金额:
$ 22.98万 - 项目类别:
NHMRC Project Grants
Mouse Model for Nemaline Myopathy
线形肌病小鼠模型
- 批准号:
nhmrc : 990071 - 财政年份:1999
- 资助金额:
$ 22.98万 - 项目类别:
NHMRC Project Grants
相似海外基金
Role of novel histone modifications and variants in transcriptional regulation
新型组蛋白修饰和变异在转录调控中的作用
- 批准号:
10713891 - 财政年份:2023
- 资助金额:
$ 22.98万 - 项目类别:
Epigenetic and transcriptional regulation of a novel T-follicular helper (TFH)-to-T-regulatory type-1 (TR1) cell differentiation pathway
新型滤泡辅助性 T (TFH) 至 T 调节型 1 (TR1) 细胞分化途径的表观遗传和转录调控
- 批准号:
461070 - 财政年份:2022
- 资助金额:
$ 22.98万 - 项目类别:
Operating Grants
Tetrahymena thermophila - a evolutionary divergent model to uncover novel mode of transcriptional regulation
嗜热四膜虫——一种揭示转录调控新模式的进化趋异模型
- 批准号:
571480-2021 - 财政年份:2022
- 资助金额:
$ 22.98万 - 项目类别:
Alliance Grants
Origins and evolution of a novel mechanism of post-transcriptional gene regulation by the HERC family
HERC家族转录后基因调控新机制的起源和进化
- 批准号:
RGPIN-2018-05793 - 财政年份:2022
- 资助金额:
$ 22.98万 - 项目类别:
Discovery Grants Program - Individual
Origins and evolution of a novel mechanism of post-transcriptional gene regulation by the HERC family
HERC家族转录后基因调控新机制的起源和进化
- 批准号:
RGPIN-2018-05793 - 财政年份:2021
- 资助金额:
$ 22.98万 - 项目类别:
Discovery Grants Program - Individual
Tetrahymena thermophila - a evolutionary divergent model to uncover novel mode of transcriptional regulation
嗜热四膜虫——一种揭示转录调控新模式的进化趋异模型
- 批准号:
571480-2021 - 财政年份:2021
- 资助金额:
$ 22.98万 - 项目类别:
Alliance Grants
Establishment of a Novel Treatment for Rett Syndrome Focusing on MeCP2-LBX1 Transcriptional Regulation
建立针对 MeCP2-LBX1 转录调控的 Rett 综合征新疗法
- 批准号:
20K07307 - 财政年份:2020
- 资助金额:
$ 22.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A novel strategy for dentin regeneration by transcriptional regulation of Runx2
通过 Runx2 转录调控实现牙本质再生的新策略
- 批准号:
20K21673 - 财政年份:2020
- 资助金额:
$ 22.98万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Origins and evolution of a novel mechanism of post-transcriptional gene regulation by the HERC family
HERC家族转录后基因调控新机制的起源和进化
- 批准号:
RGPIN-2018-05793 - 财政年份:2020
- 资助金额:
$ 22.98万 - 项目类别:
Discovery Grants Program - Individual
Illuminating novel roles for the Ldb1 co-regulator in transcriptional regulation of brown adipose function
阐明 Ldb1 协同调节因子在棕色脂肪功能转录调节中的新作用
- 批准号:
9921202 - 财政年份:2019
- 资助金额:
$ 22.98万 - 项目类别: