NRSA Training Core

NRSA 培训核心

• 批准号: 10627923
• 负责人: Kenneth G Saag
• 金额: $ 69.56万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-06 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10627923
• 关键词: Acceleration; Clinical; Clinical Research; Clinical Sciences; Communities; Deep South; Degree program; Development; Discipline; Disease; Doctor of Pharmacy; Doctor of Philosophy; Educational Curriculum; Educational process of instructing; Enrollment; Ethnic Origin; Funding; Future; Gender; Geography; Goals; Institution; Intervention; Learning; Mentors; Modeling; Multilingualism; National Research Service Awards; Phase; Productivity; Research; Research Personnel; Scientist; Students; Thinking; Training; Training Programs; Translational Research; Work; bridge program; career development; clinical center; community building; design; doctoral student; experience; fundamental research; human disease; improved; innovation; interest; member; novel; population health; pre-doctoral; programs; racial diversity; recruit; skill acquisition; skills; synergism; translational engagement; translational scientist

ABSTRACT - J. TRAINING CORE (TL1). There is a growing gap between fundamental research and the translation of this research into clinical interventions. In order improve our understanding and treatment of human disease, it is essential to develop translational scientists that are able to move from being narrow, project-focused disciplinary researchers into cross-disciplinary scientists and members of engaged translational science teams. Translational science teams will allow for disciplinary barriers to be broken and integration of unique perspectives and thought models to be incorporated so that scientific innovation can be accelerated. Our Center for Clinical and Translational Science (CCTS) Deep South Translational Thinker Training Program (TL1) bridges fundamental discovery and clinical research through to population health by enhancing interest in translational research and engaging our trainees in a curriculum that takes disciplinary scientists and teaches them how to become multi-lingual members of cross-disciplinary translational science teams. The overall goal of this proposal is develop future translational scientists by cultivating trainees of diverse racial, ethnic, gender, disciplinary, and institutional backgrounds in a novel program of team training, skill development, and community building. The CCTS TL1 has three main components: 1) the Pre-TL1 Phase focuses on showcasing the value of translational science, the impact of clinicians and scientists who can work in translational science teams, and on identification and recruitment of TL1 trainees; 2) the TL1 Research Phase immerses the trainee in a research experience with a skilled and productive researcher who has an excellent mentoring track record and an actively funded research program focusing on translational science. During this research phase that the trainees TL1 appointed trainees learn about cross-disciplinary teams and translational thinking; and 3) the Post-TL1 Phase focuses on retention and continuing career development for the trainees and will continue at least as long as the trainee is a member of our CCTS Partner Institution community. Our CCTS TL1 program will train 15 pre-doctoral students annually from our Hub and Partner Network who are enrolled in PhD, MD, DDS/DMD, DVM/VMD, PharmD, or dual-degree programs and who are seeking a practical, cross-disciplinary introduction to clinical and translational research. This training program design develops a community of trainees from geographic separated students, while also emphasizing discipline-specific depth and transdisciplinary synergy. This facilitates the development of future translational researchers who will work to reduce the diseases that disproportionately burden our Deep South Region.

摘要-J。培训核心（TL1）。基础研究与 将这项研究转化为临床干预措施。为了提高我们对 人类疾病，发展能够从狭窄的转化科学家，至关重要 以项目为重点的纪律研究人员进入跨学科科学家和参与的成员 翻译科学团队。翻译科学团队将允许纪律障碍被打破，并且 将独特的观点和思想模型整合到要纳入的整合，以便科学创新可以 加速。我们的临床与转化科学中心（CCTS）深南翻译思想家 培训计划（TL1）将基本发现和临床研究桥梁通过 增强对翻译研究的兴趣，并让我们的学员参加纪律处分的课程 科学家并教他们如何成为跨学科转化科学的多语言成员 团队。该提案的总体目标是通过培养受训者来发展未来的翻译科学家 在一个新颖的团队计划中，各种各样的种族，种族，性别，纪律和机构背景 培训，技能发展和社区建设。 CCTS TL1具有三个主要组成部分：1） TL1阶段的重点是展示转化科学的价值，临床医生和科学家的影响 谁可以在转化科学团队中工作，以及对TL1学员的认同和招聘； 2）TL1 研究阶段使学员与熟练和富有成效的研究人员进行研究经验 拥有出色的指导记录和一个积极资助的研究计划，重点是翻译 科学。在这个研究阶段，学员TL1任命的学员了解跨学科 团队和翻译思维； 3）TL1后阶段着重于保留和持续职业 学员的发展，至少将继续持续到学员是我们的CCTS合作伙伴的成员 机构社区。我们的CCTS TL1计划将每年从我们的枢纽培训15名博士前学生， 合作伙伴网络已入学博士，医学博士，DDS/DMD，DVM/VMD，PharmD或双级计划以及 正在寻求临床和转化研究的实用，跨学科介绍。这个培训 计划设计开发了来自地理分离学生的学员社区，同时也 强调特定学科的深度和跨学科协同作用。这有助于未来的发展 翻译研究人员将努力减少对我们深南方的不成比例负担的疾病 地区。

项目成果

Correction: Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer.

纠正：神经节苷脂GD2的表达，重新编程膀胱癌中的脂质代谢和EMT表型。

• DOI: 10.18632/oncotarget.27311
• 发表时间: 2019
• 期刊: Oncotarget
• 作者: Vantaku,Venkatrao;Donepudi,SriRamya;Ambati,ChandrashekarR;Jin,Feng;Putluri,Vasanta;Nguyen,Khoa;Rajapakshe,Kimal;Coarfa,Cristian;Battula,VenkataLokesh;Lotan,Yair;Putluri,Nagireddy
• 通讯作者: Putluri,Nagireddy

Mental Health and Psychotropic Stigma Among Student Pharmacists.

• DOI: 10.3389/fpubh.2022.818034
• 发表时间: 2022
• 期刊: Frontiers in public health
• 影响因子: 5.2
• 作者: Davis B;McDaniel CC;Wang CH;Garza KB
• 通讯作者: Garza KB

The Effects of Diabetes Self-Management Education on Quality of Life for Persons With Type 1 Diabetes: A Systematic Review of Randomized Controlled Trials.

• DOI: 10.1177/26350106211070266
• 发表时间: 2022-04
• 期刊: SCIENCE OF DIABETES SELF-MANAGEMENT AND CARE
• 影响因子: 1.9
• 作者: Davidson, Patricia;LaManna, Jacqueline;Davis, Jean;Ojeda, Maria M.;Hyer, Suzanne;Dickinson, Jane K.;Todd, Andrew;Hammons, Tamara M.;Fahim, Shahariar Mohammed;McDaniel, Cassidi C.;McKee, Cynthia A.;Clements, Jennifer N.;Yehl, Kirsten;Litchman, Michelle L.;Blanchette, Julia E.;Kavookjian, Jan
• 通讯作者: Kavookjian, Jan

Engineered cardiac tissue microsphere production through direct differentiation of hydrogel-encapsulated human pluripotent stem cells

• DOI: 10.1016/j.biomaterials.2021.120818
• 发表时间: 2021-05-21
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Finklea, Ferdous B.;Tian, Yuan;Lipke, Elizabeth A.
• 通讯作者: Lipke, Elizabeth A.

Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations.

• DOI: 10.31083/j.fbl2706196
• 发表时间: 2022-06
• 期刊: Frontiers in bioscience
• 作者: Khoa Nguyen;Hassan Yousefi;T. Cheng;Justin W. Magrath;A. Hartono;M. Alzoubi;K. Hebert;Courtney K. Brock;M. Wright;C. Byrne;Andrew Rivera;Sam C. Okpechi;M. Matossian;H. Wathieu;S. Elliott;M. Mondrinos;Sean B Lee;B. Collins-Burow;S. Alahari;D. Drewry;M. Burow