DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAM

深南转化研究指导职业发展计划

基本信息

批准号：
10641020
负责人：
Kenneth G Saag
金额：
$ 104.32万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-06 至 2024-06-30
项目状态：
已结题

项目摘要

We propose the Deep South Translational Research Mentored Career Development Program KL2 to focus on the growing gap between research and the translation of research into clinical practice that has been labeled the “valley of death”. Our Partner Network brings existing training infrastructure, ongoing partnerships, and complementary research expertise in diseases and disparities that are disproportionately represented within an area of the southeastern US known as the “Deep South”. We aim to create a career development program that fosters “team science” and instills scholars with mastery of translational research (TR) core competencies through an intensive curriculum that will nurture “translational thinking” by helping Scholars use logic, imagination, intuition, and systemic reasoning, to examine potential solutions to diseases and conditions that disproportionately affect the Deep South. Over the grant period, we intend to provide enhanced training for 18 early career faculty scholars who will be supported by a collaborative research base (109 mentors) supported by more than $315 million in extramural funding. Our overall goal for this career development program is to facilitate new, and expand existing, innovative opportunities to train early career faculty across the T1-TR spectrum in areas such as drug discovery and development, integrative “omics”, clinical informatics, and outcomes research aimed at addressing disease and health care disparities that disproportionately affect the Deep South. We will mentor these early career investigators towards becoming academic leaders within our CCTS Partner Network and nationally. Our specific aims are to: 1) Identify, recruit, and cultivate a diverse cohort of early career faculty investigators across the Partner Network; 2) Enhance the personalized career development of translational scientists from a broad range of clinical and methodological disciplines through individual, peer, and team mentoring particularly focused on future grant development and grant submission support to assist in the transition towards an independent research career; 3) Provide a curriculum and collaborative, multidisciplinary experiential training in translational research incorporating a spectrum of clinical disorders, with emphasis on prevalent diseases and health disparities in the US Deep South; 4) Advance mentoring and team building skills of faculty to foster “team science” and continue the expansion of cross-institutional training experiences for KL2 Scholars and other early career investigators; The Deep South Translational Research KL2 will provide new and expand existing infrastructure across our regional partners for career development, to recruit and train individuals with significant potential to be highly successful translational researchers, and to mentor them toward becoming academic leaders at our institutions and nationally, and ultimately to improve healthcare in the Deep South.

我们提出了深南转化研究的指导职业发展计划KL2的计划专注于研究与研究转化为临床之间的日益增长的差距练习被标记为“死亡谷”。我们的合作伙伴网络带来了现有的培训基础设施，持续的伙伴关系以及疾病和分布的互补研究专业知识在美国东南部被称为“深南”的地区内的不成比例。我们的目标创建一项职业发展计划，培养“团队科学”，并以精通学者的方式灌输学者翻译研究（TR）核心能力通过强化课程，该课程将护理“翻译思考”通过帮助学者使用逻辑，想象力，直觉和系统性推理来检查潜力对疾病和条件的解决方案不成比例地影响南方深处。在整个赠款期间，我们打算为18名早期职业学院学者提供增强的培训合作研究基础（109名导师）得到了超过3.15亿美元的校外资金。我们的该职业发展计划的总体目标是促进新的，扩大现有的创新性在诸如药物发现等领域训练跨T1-TR谱系训练早期职业教师的机会和开发，综合“ OMIC”，临床信息和旨在的结果研究解决疾病和卫生保健差异不成比例地影响南方。我们将指导这些早期的职业调查人员，以成为CCTS合作伙伴的学术领导者网络和全国。我们的具体目的是：1）识别，招募和培养潜水员的早期队列合作伙伴网络的职业教师调查员； 2）增强个性化的职业发展通过个人，同伴，来自各种临床和方法学学科的转化科学家团队的心理专注于未来的赠款发展和赠款提交支持，以协助向独立研究职业的过渡； 3）提供课程和协作，翻译研究的多学科专家培训，结合了一系列临床疾病，强调美国深处的流行疾病和健康差异； 4）提前心理以及教师的团队建设技能，以促进“团队科学”并继续扩展跨机构 KL2学者和其他早期职业调查人员的培训经验；深南翻译研究KL2将为我们的区域合作伙伴提供新的和扩展现有的基础设施职业发展，招募和培训具有巨大成功潜力的个人翻译研究人员，并指导他们成为我们机构的学术领导者在全国范围内，最终是为了改善南方深处的医疗保健。

项目成果

期刊论文数量（28）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Impact of Donor Hepatitis C Virus on Kidney Transplant Outcomes for Hepatitis C-positive Recipients in the Direct-acting Antiviral Era: Time to Revise the Kidney Donor Risk Index?

DOI：
10.1097/tp.0000000000002949
发表时间：
2020-06-01
期刊：
TRANSPLANTATION
影响因子：
6.2
作者：
Cannon, Robert M.;Locke, Jayme E.;Jones, Christopher M.
通讯作者：
Jones, Christopher M.

Examination of race and infrainguinal bypass conduit use in the Society for Vascular Surgery Vascular Quality Initiative.

DOI：
10.1177/1708538120927704
发表时间：
2020-12
期刊：
Vascular
影响因子：
1.1
作者：
Stewart L;Pearce BJ;Beck AW;Spangler EL
通讯作者：
Spangler EL

Using Mixed Methods Research in Children with Type 1 Diabetes: a Methodological Review.

DOI：
10.1007/s11892-023-01509-z
发表时间：
2023-07
期刊：
CURRENT DIABETES REPORTS
影响因子：
4.2
作者：
Davis, Sara L.;Jaser, Sarah S.;Ivankova, Nataliya V.;Lemley, Trey;Rice, Marti
通讯作者：
Rice, Marti

Using Nursing Assessments of Mobility and Activity to Prioritize Patients Most Likely to Need Rehabilitation Services.

利用行动能力和活动的护理评估来优先考虑最有可能需要康复服务的患者。

DOI：
10.1016/j.apmr.2023.03.018
发表时间：
2023
期刊：
Archives of physical medicine and rehabilitation
影响因子：
4.3
作者：
Capo-Lugo,CarmenE;McLaughlin,KevinH;Ye,Bingqing;Daley,Kelly;Young,Daniel;Lavezza,Annette;Friedman,Michael;Hoyer,ErikH
通讯作者：
Hoyer,ErikH

Effects of statin and antiplatelet therapy noncompliance and intolerance on patient outcomes following vascular surgery.

他汀类药物和抗血小板治疗不依从和不耐受对血管手术后患者预后的影响。

DOI：
10.1016/j.jvs.2019.07.063
发表时间：
2020
期刊：
Journal of vascular surgery
影响因子：
4.3
作者：
Moore,JohnstonL;McFarland,GraemeE;Novak,Zdenek;Patterson,MarkA;Haverstock,Brent;Passman,MarcA;Spangler,EmilyL;Pearce,BenjaminJ;Beck,AdamW
通讯作者：
Beck,AdamW