DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAM

我们建议深南转化研究指导职业发展 计划KL 2专注于研究与将研究转化为临床之间日益扩大的差距 被称为“死亡之谷”的做法。我们的合作伙伴网络将现有的培训基础设施， 持续的伙伴关系，以及在疾病和差距方面的互补研究专长， 在美国东南部一个被称为“南方腹地”的地区，我们的目标是 创建一个职业发展计划，培养“团队科学”，并灌输学者掌握 翻译研究（TR）的核心能力，通过强化课程，将培养“翻译 思维”，帮助学者运用逻辑、想象、直觉和系统推理， 解决不成比例地影响南方腹地的疾病和状况。在这段时间里，我们 打算为18名早期职业教师学者提供强化培训，他们将得到 合作研究基地（109名导师）得到超过3.15亿美元的校外资金支持。我们 这个职业发展计划的总体目标是促进新的，并扩大现有的，创新的， 在药物发现等领域培训T1-TR早期职业教师的机会 和发展，综合“组学”，临床信息学和成果研究，旨在 解决不成比例地影响南方腹地的疾病和医疗保健差距。我们将 指导这些早期职业研究人员成为我们CCTS合作伙伴的学术领袖 网络和国家。我们的具体目标是：1）识别，招募和培养一个多元化的早期群体 整个合作伙伴网络的职业教师调查员; 2）加强个性化的职业发展， 来自广泛的临床和方法学科的翻译科学家，通过个人，同行， 和团队指导特别侧重于未来的赠款开发和赠款提交支持，以协助 过渡到一个独立的研究生涯; 3）提供一个课程和协作， 在转化研究中的多学科经验培训，包括一系列临床疾病， 重点关注美国南部腹地的流行疾病和健康差距; 4）提前指导 和教师的团队建设技能，以促进“团队科学”，并继续扩大跨机构 KL 2学者和其他早期职业调查人员的培训经验;深南翻译 研究KL 2将为我们的区域合作伙伴提供新的和扩展现有的基础设施， 职业发展，招聘和培训具有巨大潜力的个人，使其获得高度成功 翻译研究人员，并指导他们成为我们机构的学术领袖 在全国范围内，并最终改善南方腹地的医疗保健。

We propose the Deep South Translational Research Mentored Career Development Program KL2 to focus on the growing gap between research and the translation of research into clinical practice that has been labeled the “valley of death”. Our Partner Network brings existing training infrastructure, ongoing partnerships, and complementary research expertise in diseases and disparities that are disproportionately represented within an area of the southeastern US known as the “Deep South”. We aim to create a career development program that fosters “team science” and instills scholars with mastery of translational research (TR) core competencies through an intensive curriculum that will nurture “translational thinking” by helping Scholars use logic, imagination, intuition, and systemic reasoning, to examine potential solutions to diseases and conditions that disproportionately affect the Deep South. Over the grant period, we intend to provide enhanced training for 18 early career faculty scholars who will be supported by a collaborative research base (109 mentors) supported by more than $315 million in extramural funding. Our overall goal for this career development program is to facilitate new, and expand existing, innovative opportunities to train early career faculty across the T1-TR spectrum in areas such as drug discovery and development, integrative “omics”, clinical informatics, and outcomes research aimed at addressing disease and health care disparities that disproportionately affect the Deep South. We will mentor these early career investigators towards becoming academic leaders within our CCTS Partner Network and nationally. Our specific aims are to: 1) Identify, recruit, and cultivate a diverse cohort of early career faculty investigators across the Partner Network; 2) Enhance the personalized career development of translational scientists from a broad range of clinical and methodological disciplines through individual, peer, and team mentoring particularly focused on future grant development and grant submission support to assist in the transition towards an independent research career; 3) Provide a curriculum and collaborative, multidisciplinary experiential training in translational research incorporating a spectrum of clinical disorders, with emphasis on prevalent diseases and health disparities in the US Deep South; 4) Advance mentoring and team building skills of faculty to foster “team science” and continue the expansion of cross-institutional training experiences for KL2 Scholars and other early career investigators; The Deep South Translational Research KL2 will provide new and expand existing infrastructure across our regional partners for career development, to recruit and train individuals with significant potential to be highly successful translational researchers, and to mentor them toward becoming academic leaders at our institutions and nationally, and ultimately to improve healthcare in the Deep South.