The Early Growth and Development Study Cohort of the ECHO Program

ECHO 项目的早期生长和发育研究队列

• 批准号: 10745202
• 负责人: Jody M. Ganiban
• 金额: $ 194.04万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745202
• 关键词: 20 year old; Address; Adherence; Adolescence; Adolescent; Affect; Age; Area; Attention deficit hyperactivity disorder; Award; Biological; Biology; Birth; Brain; Calibration; Characteristics; Child; Child Development; Child Health; Child Mental Health; Child Rearing; Child Support; Childbirth; Childhood; Classification; Cohort Studies; Conceptions; Conduct Disorder; Data; Data Element; Development; Dimensions; Discrimination; Economics; Emotional; Enrollment; Ensure; Environment; Environmental Exposure; Esthesia; Ethnic Origin; Ethnic Population; Family; Follow-Up Studies; Funding; Generations; Geography; Goals; Growth; Growth and Development function; Health; Individual; Individual Differences; Infrastructure; Intervention; Interviewer; Investigation; Knowledge; Lead; Link; Longevity; Longitudinal Studies; Low income; Manuscripts; Mental Health; Methods; Minority; Modeling; Neighborhoods; Neurodevelopmental Problem; Outcome; Outcome Measure; Parents; Participant; Pediatric cohort; Phase; Policies; Population Heterogeneity; Predisposition; Pregnancy; Process; Productivity; Protocols documentation; Psychologist; Research Design; Research Infrastructure; Research Personnel; Risk; Risk Factors; Role; Sampling; Science; Shapes; Siblings; Site; Societies; Standardization; System; Temperament; Testing; Time; Training; Work; aged; anxiety symptoms; cohort; data sharing; depressive symptoms; design; follow-up; improved; infancy; insight; middle childhood; neurodevelopment; novel; peer; phase 2 study; prenatal; programs; protective factors; psychosocial; racial identity; racial population; recruit; resilience; retention rate; rural area; social; success; urban area

Project Summary The combined economic and personal effects of children’s neurodevelopmental problems, such as conduct disorder, ADHD, and depression and anxiety symptoms are substantial. At the same time, there is growing evidence that dimensions of positive health can support children in leading meaningful, productive lives. In the current proposal we address knowledge gaps related to the timing of psychosocial environmental exposures and when their effects on child neurodevelopment and positive health emerge, and at what ages children’s risk factors and assets are most potent in affecting developmental trajectories. We also propose to examine the transition to adolescence. Adolescence can be a turning point in child development given rapid changes in the brain, emotional, and social system, yet longitudinal studies from infancy to adolescence with large cohorts of children from diverse backgrounds are sorely lacking. Last, children’s neurodevelopment and positive health are rarely examined in concert, leading to incomplete assessments of children’s mental health at all phases of development. This application seeks to fill some of these knowledge gaps through participation in the Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up Program. In this application, we propose to follow an existing sample of 1,000 children from the Early Growth and Development Study (EGDS) cohort who are enrolled as Level 2 participants in the ECHO Program and have ECHO Cohort Protocol data elements beginning in the prenatal period. EGDS is a nationwide sample of children living with either their adoptive or biological parent(s). Children will be age 7 – 20 years old and assessed annually using the ECHO Cohort Protocol in the proposed study. We have been highly successful in achieving our planned recruitment and enrollment rates, collecting and sharing data with the ECHO Program, and contributing to ECHO-wide science and manuscripts in the current ECHO funding cycle. We will build on our successes and infrastructure to contribute to ECHO’s goals through leading collaborative ECHO Cohort science, with a dual focus on ECHO Cohort Protocol core data elements and on two specialized child outcome areas: Neurodevelopment and Child Positive Health. Through three specific aims, we will: (1) leverage ECHO Cohort Protocol core data elements to examine the immediate and latent impact of early exposures on child health outcomes across different developmental periods in diverse contexts; (2) leverage data from specialized outcomes to test predictors of change in neurodevelopment and positive health in adolescence; and, (3) implement data-driven check points every quarter to assess our retention of existing cohort participants, with an emphasis on diversity and implementation of the protocol with high fidelity. Our overall goal is to work collaboratively with the ECHO Program to advance the understanding of predictors and outcomes of child health in order to inform programs, practices, and policies that will improve the health of children for generations to come.

项目摘要 儿童神经发育问题的经济和个人影响，例如行为 疾病，多动症以及抑郁症和动画症状是很大的。同时，正在增长 证据表明，积极健康的维度可以为儿童带来有意义的产品生活。在 当前建议我们解决与社会心理环境暴露时间有关的知识差距 当他们对儿童神经发育和阳性健康的影响以及儿童的风险 因素和资产在影响发展轨迹方面最有潜力。我们还建议检查 过渡到青少年。鉴于该青少年可能是儿童发育的转折点 大脑，情感和社交系统，但从婴儿期到青少年的纵向研究， 来自潜水员背景的孩子非常缺乏。最后，儿童的神经发育和积极的健康 很少在一致的协同中检查，从而导致对儿童心理健康的不完整评估 发展。本申请通过参与来填补这些知识差距 环境对儿童健康结果的影响（ECHO）队列研究地点用于小儿随访 程序。在本申请中，我们建议关注早期增长中的1,000名儿童的现有样本 和开发研究（EGD）队列，他们是ECHO计划的2级参与者， 具有回声队列协议数据元素从产前期开始。 EGD是国家样本 与自适应或亲生父母一起生活的孩子。儿童将年满7至20岁， 在拟议的研究中使用回声队列方案每年评估。我们在 实现我们计划的招聘和入学率，与Echo计划收集和共享数据， 并在当前的回声融资周期中为范围的范围内的科学和手稿做出了贡献。我们将基础 我们的成功和基础架构通过领先的合作回声队列为Echo的目标做出贡献 科学，双重关注回声队列协议核心数据元素以及两个专业的儿童结果 区域：神经发育和儿童阳性健康。通过三个特定目标，我们将：（1）利用Echo 队列协议核心数据要素，以检查早期暴露对儿童的直接和潜在影响 潜水员背景下不同发育时期的健康结果； （2）利用专业的数据 测试青少年神经发育变化和阳性健康变化的预测因素；和（3） 每个季度实施数据驱动的检查点，以评估我们对现有队列参与者的保留，并 强调以高忠诚的多样性和实施协议的实施。我们的总体目标是工作 与Echo计划合作，以提高对儿童预测因素和结果的理解 健康以告知计划，惯例和政策，以改善儿童的健康 几代人即将到来。