The Early Growth and Development Study Cohort of the ECHO Program

ECHO 项目的早期生长和发育研究队列

• 批准号: 10745202
• 负责人: Jody M. Ganiban
• 金额: $ 194.04万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745202
• 关键词: 20 year old; Address; Adherence; Adolescence; Adolescent; Affect; Age; Area; Attention deficit hyperactivity disorder; Award; Biological; Biology; Birth; Brain; Calibration; Characteristics; Child; Child Development; Child Health; Child Mental Health; Child Rearing; Child Support; Childbirth; Childhood; Classification; Cohort Studies; Conceptions; Conduct Disorder; Data; Data Element; Development; Dimensions; Discrimination; Economics; Emotional; Enrollment; Ensure; Environment; Environmental Exposure; Esthesia; Ethnic Origin; Ethnic Population; Family; Follow-Up Studies; Funding; Generations; Geography; Goals; Growth; Growth and Development function; Health; Individual; Individual Differences; Infrastructure; Intervention; Interviewer; Investigation; Knowledge; Lead; Link; Longevity; Longitudinal Studies; Low income; Manuscripts; Mental Health; Methods; Minority; Modeling; Neighborhoods; Neurodevelopmental Problem; Outcome; Outcome Measure; Parents; Participant; Pediatric cohort; Phase; Policies; Population Heterogeneity; Predisposition; Pregnancy; Process; Productivity; Protocols documentation; Psychologist; Research Design; Research Infrastructure; Research Personnel; Risk; Risk Factors; Role; Sampling; Science; Shapes; Siblings; Site; Societies; Standardization; System; Temperament; Testing; Time; Training; Work; aged; anxiety symptoms; cohort; data sharing; depressive symptoms; design; follow-up; improved; infancy; insight; middle childhood; neurodevelopment; novel; peer; phase 2 study; prenatal; programs; protective factors; psychosocial; racial identity; racial population; recruit; resilience; retention rate; rural area; social; success; urban area

Project Summary The combined economic and personal effects of children’s neurodevelopmental problems, such as conduct disorder, ADHD, and depression and anxiety symptoms are substantial. At the same time, there is growing evidence that dimensions of positive health can support children in leading meaningful, productive lives. In the current proposal we address knowledge gaps related to the timing of psychosocial environmental exposures and when their effects on child neurodevelopment and positive health emerge, and at what ages children’s risk factors and assets are most potent in affecting developmental trajectories. We also propose to examine the transition to adolescence. Adolescence can be a turning point in child development given rapid changes in the brain, emotional, and social system, yet longitudinal studies from infancy to adolescence with large cohorts of children from diverse backgrounds are sorely lacking. Last, children’s neurodevelopment and positive health are rarely examined in concert, leading to incomplete assessments of children’s mental health at all phases of development. This application seeks to fill some of these knowledge gaps through participation in the Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up Program. In this application, we propose to follow an existing sample of 1,000 children from the Early Growth and Development Study (EGDS) cohort who are enrolled as Level 2 participants in the ECHO Program and have ECHO Cohort Protocol data elements beginning in the prenatal period. EGDS is a nationwide sample of children living with either their adoptive or biological parent(s). Children will be age 7 – 20 years old and assessed annually using the ECHO Cohort Protocol in the proposed study. We have been highly successful in achieving our planned recruitment and enrollment rates, collecting and sharing data with the ECHO Program, and contributing to ECHO-wide science and manuscripts in the current ECHO funding cycle. We will build on our successes and infrastructure to contribute to ECHO’s goals through leading collaborative ECHO Cohort science, with a dual focus on ECHO Cohort Protocol core data elements and on two specialized child outcome areas: Neurodevelopment and Child Positive Health. Through three specific aims, we will: (1) leverage ECHO Cohort Protocol core data elements to examine the immediate and latent impact of early exposures on child health outcomes across different developmental periods in diverse contexts; (2) leverage data from specialized outcomes to test predictors of change in neurodevelopment and positive health in adolescence; and, (3) implement data-driven check points every quarter to assess our retention of existing cohort participants, with an emphasis on diversity and implementation of the protocol with high fidelity. Our overall goal is to work collaboratively with the ECHO Program to advance the understanding of predictors and outcomes of child health in order to inform programs, practices, and policies that will improve the health of children for generations to come.

项目摘要 儿童神经发育问题的综合经济和个人影响，如行为 障碍，多动症，抑郁和焦虑症状是实质性的。与此同时， 有证据表明，积极健康的各个方面可以支持儿童过上有意义、有成效的生活。在 目前的建议，我们解决知识差距有关的时间，心理社会环境暴露 以及它们对儿童神经发育和积极健康的影响何时出现，以及儿童的风险年龄 各种因素和资产对发展轨迹的影响最大。我们亦建议研究 过渡到青春期。青春期可能是儿童发展的转折点，因为社会环境发生了迅速变化。 大脑，情感和社会系统，但从婴儿期到青春期的纵向研究， 来自不同背景的儿童非常缺乏。最后，儿童的神经发育和积极健康 很少一起检查，导致对儿童心理健康的所有阶段的评估不完整。 发展本申请旨在通过参与 环境对儿童健康结局（ECHO）队列研究中心的儿科随访影响 程序.在这个应用程序中，我们建议遵循现有的1,000名儿童的样本，从早期成长， 在ECHO计划中作为2级参与者入组的儿童发展研究（EGDS）队列， 具有从产前开始的ECHO队列方案数据元素。EGDS是一个全国性的样本， 与养父母或亲生父母生活在一起的儿童。儿童年龄为7 - 20岁， 在拟定的研究中，每年使用ECHO队列方案进行评估。我们在以下方面取得了巨大成功： 实现我们计划的招募和入组率，收集并与ECHO计划共享数据， 并在当前的ECHO资助周期内为ECHO范围内的科学和手稿做出贡献。我们将建立在 我们的成功和基础设施，通过领先的合作ECHO队列，为ECHO的目标做出贡献 科学，双重重点是ECHO队列方案核心数据元素和两个专门的儿童结局 领域：神经发育和儿童积极健康。通过三个具体目标，我们将：（1）利用ECHO 研究早期接触对儿童的直接和潜在影响的队列方案核心数据要素 不同背景下不同发展阶段的健康结果;（2）利用来自专业 测试青春期神经发育和积极健康变化的预测因素的结果;以及，（3） 每个季度实施数据驱动的检查点，以评估我们对现有队列参与者的保留情况， 强调协议的多样性和高保真度的实现。我们的总体目标是 与ECHO计划合作，以促进对儿童疾病预测因素和结果的理解。 健康，以便为改善儿童健康的计划，实践和政策提供信息， 后代人来说