Data Management and Analysis Core

数据管理与分析核心

基本信息

  • 批准号:
    10622448
  • 负责人:
  • 金额:
    $ 43.58万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-15 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY / ABSTRACT (Data Management and Analysis Core) The Data Management and Analysis (DMA) Core will provide comprehensive data science support for the Program Project Grant (PPG): Precision Cardiovascular Disease Phenotyping and Pathophysiological Pathways in the CARRS cohort (Precision-CARRS). The overarching goal of the DMA Core is to maintain high scientific rigor in the management and analysis of large and complex datasets. The DMA Core will be based at Emory University and the Center for Chronic Disease Control (CCDC) in India. The DMA Core will include 8 investigators with comprehensive data science expertise and a dedicated team of database engineer, data managers and biostatisticians from both the US and India. The DMA Core will oversee data management, data sharing, and the development of common analytic frameworks to promote integration and synergy across the interconnected aims of the Precision-CARRS Projects. The DMA Core will work closely with the Administrative and Field Coordination (AFC) Core and the CVD Phenotyping Core to ensure high quality data capture and documentation, as well as to provide continuous infrastructure and management for all research data from Precision-CARRS (Aim 1). By leveraging and expanding existing data platforms, we will establish workflows and protocols for consistent data cleaning, harmonization, monitoring and documentation for diverse datasets, including longitudinal surveys, subclinical and clinical phtenotypes, blood and urine biomarker measurements, environmental exposures, and data from high-throughput omics technologies and digital sensors. The DMA Core will also work closely with all Reseach Projects to provide centralized support for data analysis using state-of-the-art biostatistics, bioinformatics and maching learning methods (Aim 2). Specifically, the DMA Core will create synchronized analytic plans for both epidemiologic modeling and predictive equation development across projects. To provide integrated and timely data science support throughout the PPG, two DMA Core investigators (one from Emory and one from CCDC) will serve as liaisons for each Core and Project. Finally, the DMA core will support the development of new and innovative analytic methods motivated by the scientific goals of Precision-CARRS (Aim 3). The DMA Core is particularly poised to contribute in the areas of machine learning for predictive health, latent variable models for handling multivariate and structured data, high-dimensional methods for multi-omics, and integrative analysis of heterogeneous data types. In summary, the DMA Core will be an integral component for Precision-CARRS by offering essential data management and analysis support for PPG research aims, while enhancing the reliability, relevance and reproducility of the PPG’s findings to utlimately sustain the long-term impact and collaborative potential of Precision-CARRS.
项目摘要/摘要(数据管理与分析核心)

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Howard H Chang其他文献

The Effect of Novel Antipsychotics on Cognitive Function
新型抗精神病药对认知功能的影响
  • DOI:
    10.3928/0048-5713-19991101-10
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0.5
  • 作者:
    I. Berman;D. Klegon;H. Fiedosewicz;Howard H Chang
  • 通讯作者:
    Howard H Chang
Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality
  • DOI:
    10.1016/j.envint.2024.109147
  • 发表时间:
    2024-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sarah LaPointe;Jaqueline C Lee;Zsolt P Nagy;Daniel B Shapiro;Howard H Chang;Yifeng Wang;Armistead G Russell;Heather S Hipp;Audrey J Gaskins
  • 通讯作者:
    Audrey J Gaskins
Treatment Issues for Patients With Schizophrenia Who Have Obsessive-Compulsive Symptoms
有强迫症状的精神分裂症患者的治疗问题
  • DOI:
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Howard H Chang;I. Berman
  • 通讯作者:
    I. Berman
Is There a Distinct Subtype of Obsessive-Compulsive Schizophrenia?
强迫性精神分裂症是否存在独特的亚型?
  • DOI:
    10.3928/0048-5713-20001001-09
  • 发表时间:
    2000
  • 期刊:
  • 影响因子:
    0.5
  • 作者:
    I. Berman;Howard H Chang;D. Klegon
  • 通讯作者:
    D. Klegon
Obsessive-Compulsive Symptoms in Schizophrenia: Neuropsychological Perspectives
精神分裂症的强迫症状:神经心理学观点
  • DOI:
    10.3928/0048-5713-19990901-09
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0.5
  • 作者:
    I. Berman;Howard H Chang;D. Klegon
  • 通讯作者:
    D. Klegon

Howard H Chang的其他文献

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{{ truncateString('Howard H Chang', 18)}}的其他基金

Methods for Estimating Disease Burden of Seasonal Influenza
估计季节性流感疾病负担的方法
  • 批准号:
    10682150
  • 财政年份:
    2023
  • 资助金额:
    $ 43.58万
  • 项目类别:
Climate & Health Actionable Research and Translation Center
气候
  • 批准号:
    10835462
  • 财政年份:
    2023
  • 资助金额:
    $ 43.58万
  • 项目类别:
Data Management and Analysis Core
数据管理与分析核心
  • 批准号:
    10333814
  • 财政年份:
    2022
  • 资助金额:
    $ 43.58万
  • 项目类别:
Neighborhood transportation vulnerability and geographic patterns of diabetes-related limb loss
社区交通脆弱性和糖尿病相关肢体丧失的地理模式
  • 批准号:
    10680610
  • 财政年份:
    2022
  • 资助金额:
    $ 43.58万
  • 项目类别:
Neighborhood transportation vulnerability and geographic patterns of diabetes-related limb loss
社区交通脆弱性和糖尿病相关肢体丧失的地理模式
  • 批准号:
    10539547
  • 财政年份:
    2022
  • 资助金额:
    $ 43.58万
  • 项目类别:
Data Integration Methods for Environmental Exposures with Applications to Air Pollution and Asthma Morbidity
环境暴露数据集成方法及其在空气污染和哮喘发病率中的应用
  • 批准号:
    10288264
  • 财政年份:
    2021
  • 资助金额:
    $ 43.58万
  • 项目类别:
Climate Penalty: Climate-driven Increases in Ozone and PM2.5 Levels and Mortality
气候惩罚:气候驱动的臭氧和 PM2.5 水平和死亡率增加
  • 批准号:
    10372176
  • 财政年份:
    2021
  • 资助金额:
    $ 43.58万
  • 项目类别:
Dust storms and emergency department visits in four southwestern US states
美国西南部四个州遭遇沙尘暴和急诊室就诊
  • 批准号:
    10372201
  • 财政年份:
    2021
  • 资助金额:
    $ 43.58万
  • 项目类别:
Extreme heat events and pregnancy duration: a national study
极端高温事件与怀孕持续时间:一项全国性研究
  • 批准号:
    10159262
  • 财政年份:
    2018
  • 资助金额:
    $ 43.58万
  • 项目类别:
Extreme heat events and pregnancy duration: a national study
极端高温事件与怀孕持续时间:一项全国性研究
  • 批准号:
    9914101
  • 财政年份:
    2018
  • 资助金额:
    $ 43.58万
  • 项目类别:

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层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
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