A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study

一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究：新罕布什尔州出生队列研究

• 批准号: 10743092
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 680.84万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10743092
• 关键词: 2019-nCoV; 3 year old; Address; Advisory Committees; Agriculture; Air; Airway Disease; Antibiotics; Award; Biological; Biological Markers; Birth; Blood; COVID-19; Characteristics; Chemicals; Child; Child Development; Child Health; Childhood; Code; Cohort Analysis; Cohort Studies; Collaborations; Conceptions; Consent; DNA; Data; Data Collection; Data Element; Diet; Dietary Factors; Early identification; Early-life trauma; Employment; Enrollment; Ensure; Environmental Exposure; Environmental Risk Factor; Evaluation; Event; Family; Feces; Feedback; Fibrinogen; Food; Food Supply; Fossil Fuels; Fostering; Generations; Genetic; Geographic Locations; Geography; Goals; Growth; Hair; Hand; Health; Health Food; Health Personnel; Healthcare; Human Milk; Income; Individual; Infrastructure; Institutional Review Boards; Instruction; Knowledge; Laboratories; Lead; Leadership; Life; Light; Livestock; Manuscripts; Marketing; Measures; Meconium; Mediating; Medical; Mission; Modification; Molecular Epidemiology; New Hampshire; Noise; Nutrient; Obesity; Outcome; Participant; Pediatric cohort; Perinatal; Persons; Phase; Physical activity; Placenta; Policies; Pollution; Population; Population Heterogeneity; Pregnancy; Prospective Studies; Protocols documentation; Psychosocial Factor; Public Health; Research Personnel; Respiratory Tract Infections; Rice; Role; Rural; Rural Health; Sampling; Schools; Science; Site; Social isolation; Solid; Source; Structure of nail of toe; Talents; Temperature; Time; Tooth structure; Trace Elements; Travel; United States National Institutes of Health; Urine; Vulnerable Populations; Water; Weather; Wood stove; Work; biobank; career; central database; cohort; community-level factor; design; dietary; diversity and inclusion; early life exposure; epidemiology study; experience; follow-up; genome wide association study; gut microbiome; health determinants; health disparity; health equity; health inequalities; marginalized community; metabolomics; microbiome; neighborhood safety; neurodevelopment; novel; obesity genetics; obesity risk; offspring; perceived stress; pet animal; pregnant; programs; prospective; public health priorities; recruit; rural setting; rurality; sample collection; social; social factors; success; toxicant; vaccine response; virtual; well water; working group

Project Summary/Abstract. In this renewal application, we will advance the success of the Environmental Influences on Child Health Outcomes program that seeks to “enhance the health of children for generations to come” as one of the Pregnancy and Pediatric Cohort Study Sites. Since 2009, the New Hampshire Birth Cohort Study, a rural prospective molecular epidemiology study, has accrued data and biologic samples on pregnant people and their children with a goal of 6,000 dyads (including 1,005 new pregnancies and 2,800 children consented into ECHO) by August 2023. Data and biospecimens are being leveraged for nearly 100 Concept Proposals (each with one or more manuscripts), including Opportunity and Infrastructure awards to early career investigators and COVID-19 supplements, and with more in the pipeline. Already, 7,440 of our cohort’s biospecimens have been committed to 11 ECHO-Wide laboratory analyses led by our Dartmouth team and other investigators. This includes the ECHO Genome Wide Association Study to which most participants are contributing DNA samples. Non-DNA biologic samples available or being shipped to the ECHO Biorepository include urine, toenails, hair, blood, placenta, meconium, human milk, stool, and teeth. We took part in ECHO program leadership, committees and working groups, designing and sharing protocols, and creating instructional videos and participant feedback materials. We addressed the urgent call for health equity, fostered workforce diversity, and prioritized public health crises, including time sensitive evaluation of SARS- CoV-2 on our most vulnerable populations. We are committed to strengthening these efforts in the next phase. We responded to congressional and agency stakeholders as well as health care providers and families and plan to elevate this engagement moving forward to ensure diverse perspectives and inclusion in our cohort and impact of our work. We will recruit 1,500 additional pregnant people, enlist their conceiving partner, enroll them into a preconception cohort if planning another child and follow children previously accrued into the cohort and newly born in this study phase. We will adhere to the ECHO Cohort Protocol, rely on the program’s REDCap Central database and single IRB. We will continue to capitalize on ECHO’s unprecedented data and samples from diverse populations across the USA, along with Dartmouth’s robust infrastructure and interdisciplinary expertise. Specifically, we will (1) address rural health inequities by characterizing the rural exposome and its impact on child health outcomes, (2) determine the early drivers of lower and upper airway disease and other outcomes and the mediating role of the developing microbiome using specialized measures of exposures (e.g., dietary nutrient-toxicant composition) and outcomes (e.g., respiratory infections and vaccine response), and (3) investigate the influence of inter-pregnancy adiposity and factors of the conceiving partner on child growth using the pilot preconception cohort. Thus, our study site fills a critical niche in the ECHO program and will continue to provide leadership and collaboration in support of its overall mission.

项目摘要/摘要。在本次更新申请中，我们将推动环境计划的成功 对儿童健康成果的影响计划旨在“增强世世代代儿童的健康” 来”作为妊娠和儿科队列研究地点之一。自 2009 年以来，新罕布什尔州的出生 队列研究是一项农村前瞻性分子流行病学研究，已积累了以下方面的数据和生物样本： 孕妇及其子女的目标是 6,000 例（包括 1,005 例新怀孕和 2,800 例） 到 2023 年 8 月，数据和生物样本已被用于近 100 概念提案（每项都有一份或多份手稿），包括机会和基础设施奖 早期职业调查员和 COVID-19 补充剂，以及更多正在酝酿中。已经有 7,440 名 该队列的生物样本已致力于由我们的达特茅斯团队领导的 11 项 ECHO-Wide 实验室分析 和其他调查人员。这包括大多数参与者参与的 ECHO 全基因组关联研究 正在贡献 DNA 样本。可用或正在运送到 ECHO 的非 DNA 生物样本 生物储存库包括尿液、脚趾甲、头发、血液、胎盘、胎便、人乳、粪便和牙齿。我们采取了 参与 ECHO 项目领导、委员会和工作组、设计和共享协议，以及 创建教学视频和参与者反馈材料。我们响应了健康公平的紧急呼吁， 促进劳动力多元化，并优先处理公共卫生危机，包括对 SARS 的时间敏感评估 CoV-2 对我们最脆弱人群的影响。我们致力于在下一阶段加强这些努力。 我们对国会和机构利益相关者以及医疗保健提供者和家庭做出了回应 计划进一步提升这种参与度，以确保我们的群体中存在不同的观点和包容性， 我们工作的影响。我们将另外招募 1,500 名孕妇，招募他们的怀孕伴侣，将他们纳入其中 如果计划再生育一个孩子，则进入孕前队列，并跟踪之前已加入该队列的孩子，并且 刚出生在这个学习阶段。我们将遵守 ECHO 队列协议，依赖该计划的 REDCap 中央数据库和单一 IRB。我们将继续利用 ECHO 前所未有的数据和样本 来自美国各地的不同人群，以及达特茅斯强大的基础设施和跨学科 专业知识。具体来说，我们将 (1) 通过描述农村暴露群体及其特征来解决农村健康不平等问题 对儿童健康结果的影响，(2) 确定下呼吸道和上呼吸道疾病及其他疾病的早期驱动因素 使用专门的暴露测量（例如， 膳食营养毒物成分）和结果（例如呼吸道感染和疫苗反应），以及（3） 调查孕间肥胖及受孕伴侣因素对孩子生长的影响 使用试点孕前队列。因此，我们的研究地点填补了 ECHO 计划中的一个关键位置，并将 继续提供领导和协作以支持其总体使命。