A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study
一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究:新罕布什尔州出生队列研究
基本信息
- 批准号:10743092
- 负责人:
- 金额:$ 680.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoV3 year oldAddressAdvisory CommitteesAgricultureAirAirway DiseaseAntibioticsAwardBiologicalBiological MarkersBirthBloodCOVID-19CharacteristicsChemicalsChildChild DevelopmentChild HealthChildhoodCodeCohort AnalysisCohort StudiesCollaborationsConceptionsConsentDNADataData CollectionData ElementDietDietary FactorsEarly identificationEarly-life traumaEmploymentEnrollmentEnsureEnvironmental ExposureEnvironmental Risk FactorEvaluationEventFamilyFecesFeedbackFibrinogenFoodFood SupplyFossil FuelsFosteringGenerationsGeneticGeographic LocationsGeographyGoalsGrowthHairHandHealthHealth FoodHealth PersonnelHealthcareHuman MilkIncomeIndividualInfrastructureInstitutional Review BoardsInstructionKnowledgeLaboratoriesLeadLeadershipLifeLightLivestockManuscriptsMarketingMeasuresMeconiumMediatingMedicalMissionModificationMolecular EpidemiologyNew HampshireNoiseNutrientObesityOutcomeParticipantPediatric cohortPerinatalPersonsPhasePhysical activityPlacentaPoliciesPollutionPopulationPopulation HeterogeneityPregnancyProspective StudiesProtocols documentationPsychosocial FactorPublic HealthResearch PersonnelRespiratory Tract InfectionsRiceRoleRuralRural HealthSamplingSchoolsScienceSiteSocial isolationSolidSourceStructure of nail of toeTalentsTemperatureTimeTooth structureTrace ElementsTravelUnited States National Institutes of HealthUrineVulnerable PopulationsWaterWeatherWood stoveWorkbiobankcareercentral databasecohortcommunity-level factordesigndietarydiversity and inclusionearly life exposureepidemiology studyexperiencefollow-upgenome wide association studygut microbiomehealth determinantshealth disparityhealth equityhealth inequalitiesmarginalized communitymetabolomicsmicrobiomeneighborhood safetyneurodevelopmentnovelobesity geneticsobesity riskoffspringperceived stresspet animalpregnantprogramsprospectivepublic health prioritiesrecruitrural settingruralitysample collectionsocialsocial factorssuccesstoxicantvaccine responsevirtualwell waterworking group
项目摘要
Project Summary/Abstract. In this renewal application, we will advance the success of the Environmental
Influences on Child Health Outcomes program that seeks to “enhance the health of children for generations to
come” as one of the Pregnancy and Pediatric Cohort Study Sites. Since 2009, the New Hampshire Birth
Cohort Study, a rural prospective molecular epidemiology study, has accrued data and biologic samples on
pregnant people and their children with a goal of 6,000 dyads (including 1,005 new pregnancies and 2,800
children consented into ECHO) by August 2023. Data and biospecimens are being leveraged for nearly 100
Concept Proposals (each with one or more manuscripts), including Opportunity and Infrastructure awards to
early career investigators and COVID-19 supplements, and with more in the pipeline. Already, 7,440 of our
cohort’s biospecimens have been committed to 11 ECHO-Wide laboratory analyses led by our Dartmouth team
and other investigators. This includes the ECHO Genome Wide Association Study to which most participants
are contributing DNA samples. Non-DNA biologic samples available or being shipped to the ECHO
Biorepository include urine, toenails, hair, blood, placenta, meconium, human milk, stool, and teeth. We took
part in ECHO program leadership, committees and working groups, designing and sharing protocols, and
creating instructional videos and participant feedback materials. We addressed the urgent call for health equity,
fostered workforce diversity, and prioritized public health crises, including time sensitive evaluation of SARS-
CoV-2 on our most vulnerable populations. We are committed to strengthening these efforts in the next phase.
We responded to congressional and agency stakeholders as well as health care providers and families and
plan to elevate this engagement moving forward to ensure diverse perspectives and inclusion in our cohort and
impact of our work. We will recruit 1,500 additional pregnant people, enlist their conceiving partner, enroll them
into a preconception cohort if planning another child and follow children previously accrued into the cohort and
newly born in this study phase. We will adhere to the ECHO Cohort Protocol, rely on the program’s REDCap
Central database and single IRB. We will continue to capitalize on ECHO’s unprecedented data and samples
from diverse populations across the USA, along with Dartmouth’s robust infrastructure and interdisciplinary
expertise. Specifically, we will (1) address rural health inequities by characterizing the rural exposome and its
impact on child health outcomes, (2) determine the early drivers of lower and upper airway disease and other
outcomes and the mediating role of the developing microbiome using specialized measures of exposures (e.g.,
dietary nutrient-toxicant composition) and outcomes (e.g., respiratory infections and vaccine response), and (3)
investigate the influence of inter-pregnancy adiposity and factors of the conceiving partner on child growth
using the pilot preconception cohort. Thus, our study site fills a critical niche in the ECHO program and will
continue to provide leadership and collaboration in support of its overall mission.
项目概要/摘要。在这次更新申请中,我们将推动环境保护的成功。
对儿童健康结果的影响方案,旨在“增强几代儿童的健康,
作为妊娠和儿科队列研究中心之一。自2009年以来,新罕布什尔州出生
队列研究是一项农村前瞻性分子流行病学研究,收集了以下方面的数据和生物样本:
孕妇及其子女,目标为6 000对夫妇(包括1 005名新孕妇和2 800名
同意加入ECHO的儿童)。数据和生物样本正在被利用,
概念提案(每个提案都有一份或多份手稿),包括机会和基础设施奖,
早期职业调查人员和COVID-19补充剂,以及更多正在筹备中的产品。已经有7,440名
队列中的生物样本已被提交给由我们的达特茅斯团队领导的11个ECHO范围的实验室分析
和其他调查员。这包括ECHO全基因组关联研究,大多数参与者
正在提供DNA样本非DNA生物样本可用或正在运送至ECHO
生物储存物包括尿液、脚趾甲、毛发、血液、胎盘、胎粪、母乳、粪便和牙齿。我们带
参与ECHO项目领导、委员会和工作组,设计和共享协议,以及
制作教学视频和参与者反馈材料。我们回应了卫生公平的紧急呼吁,
促进劳动力多样性,优先处理公共卫生危机,包括对SARS的时间敏感评估-
COV-2对我们最脆弱的人群。我们致力于在下一阶段加强这些努力。
我们回应了国会和机构利益相关者以及医疗保健提供者和家庭,
我计划进一步加强这种参与,以确保我们的团队具有多样化的观点和包容性,
我们工作的影响。我们会再招募1,500名孕妇,招募她们的怀孕伴侣,
如果计划另一个孩子并跟随先前累积到队列中的孩子,
在这个学习阶段诞生的。我们将坚持ECHO队列方案,依靠该计划的REDCap
中央数据库和单一IRB。我们将继续利用ECHO前所未有的数据和样本
沿着达特茅斯强大的基础设施和跨学科的
专业知识具体而言,我们将(1)通过描述农村的麻烦及其
对儿童健康结果的影响,(2)确定下呼吸道和上呼吸道疾病的早期驱动因素以及其他
结果和使用专门的暴露测量的发育中的微生物组的介导作用(例如,
膳食营养素-毒物组成)和结果(例如,呼吸道感染和疫苗反应),以及(3)
探讨孕期肥胖及妊娠伴侣因素对儿童生长发育的影响
使用的是飞行员的先入之见队列。因此,我们的研究中心填补了ECHO计划中的关键利基,并将
继续提供领导和协作,以支持其总体使命。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARGARET Rita KARAGAS其他文献
MARGARET Rita KARAGAS的其他文献
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{{ truncateString('MARGARET Rita KARAGAS', 18)}}的其他基金
Core A: Administrative, Career Development, and Research Integration Core
核心 A:行政、职业发展和研究整合核心
- 批准号:
10630466 - 财政年份:2023
- 资助金额:
$ 680.84万 - 项目类别:
COBRE Center for Molecular Epidemiology - Equipment Supplement
COBRE 分子流行病学中心 - 设备补充
- 批准号:
10400262 - 财政年份:2021
- 资助金额:
$ 680.84万 - 项目类别:
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study
一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究:新罕布什尔州出生队列研究
- 批准号:
9262487 - 财政年份:2016
- 资助金额:
$ 680.84万 - 项目类别:
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study
一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究:新罕布什尔州出生队列研究
- 批准号:
10474633 - 财政年份:2016
- 资助金额:
$ 680.84万 - 项目类别:
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study
一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究:新罕布什尔州出生队列研究
- 批准号:
10204645 - 财政年份:2016
- 资助金额:
$ 680.84万 - 项目类别:
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study
一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究:新罕布什尔州出生队列研究
- 批准号:
10241453 - 财政年份:2016
- 资助金额:
$ 680.84万 - 项目类别:
Epidemiology, Biomarkers and Exposure Assessment of Metals
流行病学、生物标志物和金属暴露评估
- 批准号:
8881880 - 财政年份:2014
- 资助金额:
$ 680.84万 - 项目类别:
Project 1 Childhood Immune Function and Exposure (Karagas)
项目 1 儿童免疫功能和暴露(卡拉加斯)
- 批准号:
8890326 - 财政年份:2014
- 资助金额:
$ 680.84万 - 项目类别:
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EMOTIONAL AND BEHAVIOR PROBLEMS IN 1-3 YEAR OLD CHILDREN
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