A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study

一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究：新罕布什尔州出生队列研究

• 批准号: 10474633
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 525.52万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474633
• 关键词: 3 year old; 5 year old; Accelerometer; Address; Age; Archives; Asthma; Behavioral; Bioinformatics; Biological; Biological Markers; Birth; Blood; Blood specimen; Cells; Cesarean section; Child; Child Development; Child Health; Childhood; Clinical; Cohort Studies; Complex; Conceptions; Cryopreservation; DNA; DNA Methylation; Data; Data Collection; Data Element; Diagnosis; Elements; Enrollment; Environmental Exposure; Environmental Impact; Environmental Pollution; Environmental Risk Factor; Exposure to; Feces; First Pregnancy Trimester; Flow Cytometry; Gene Expression; Growth; Hair; Health; Home environment; Hospitalization; Household Air Pollution; Human; Human Milk; Infant; Intervention; Interview; Intestines; Knowledge; Laboratories; Life; Lymphocyte; Measurement; Meconium; Mediator of activation protein; Medical; Medical Records; Metals; Methodology; Monitor; Mothers; National Institute of Environmental Health Sciences; New Hampshire; Non-Prescription Drugs; Obesity; Operative Surgical Procedures; Outcome; Outcome Assessment; Participant; Pediatric cohort; Persons; Phase; Physical activity; Physical environment; Placenta; Pregnancy; Prospective Studies; Questionnaires; Records; Research; Respiratory Tract Infections; Role; Rural; Salivary; Sampling; Self Administration; Structure of nail of toe; Techniques; Technology; Testing; Time; Tooth structure; Toxic Environmental Substances; Umbilical Cord Blood; Urine; Ursidae Family; Validation; Water; Water Supply; Wood stove; air monitoring; biobank; built environment; climate change; cohort; data acquisition; detector; drinking; drinking water; early life exposure; experience; feasibility testing; fetal; follow-up; food environment; gut microbiome; improved; in utero; indoor air; innovation; lifestyle factors; metabolomics; microbiome; microbiome sequencing; neurodevelopment; novel; prenatal; pulmonary function; respiratory; respiratory health; rural area; rural setting; sample collection; sex; sleep pattern; social; stool sample; urinary; vaccine response; wood smoke

Project Summary/Abstract: Major gaps exist in our knowledge of the health impacts of widespread and dramatically expanding exposures among children in the US. Children from rural regions are particularly understudied, but may experience higher exposures to contaminants by drinking unregulated water; from household air pollution from wood stoves; and consequent to their rural and changing landscape (e.g., from climate change). As part of this ECHO Pediatric Cohorts application, we propose to take advantage of the NIEHS/EPA supported New Hampshire Birth Cohort Study (NHBCS): a rural, ongoing pregnancy cohort that has accrued over 1,500 maternal-infant dyads. By the beginning of the UH3 phase of this application, the anticipated cohort size will be 2,000, and as part of this ECHO Pediatric Cohorts application, accrual will be extended to 3,000 maternal-infant pairs. Clinical outcomes are being ascertained from interval interviews, questionnaires, medical records, in-person assessments and laboratory tests. The study has archived environmental (tap water and indoor air) and biological samples collected during pregnancy (maternal blood, urine and hair), as well as biological samples acquired at birth (infant cord blood, placenta and meconium) and during childhood (urine, blood, buccal cells, breast milk, toenails and stool). With support of a state-of-the-art biorepository, the ability to utilize these samples for a wide range of downstream analyses has been demonstrated, e.g., for DNA methylation arrays, gene expression, microbiome sequencing, metabolomics and flow cytometry. For the current application, emerging hypotheses of concern will be addressed by: (1) leveraging the extant NHBCS to perform targeted and unsupervised metabolomic analyses of 1,000 cord blood samples and 250 paired maternal gestational blood samples, and assess associations with exposures, early growth, and the infant microbiome; (2) expanding data acquisition, sample collection and participant accrual to more precisely characterize exposures and timing of early life exposures by obtaining urinary metallome and metal metabolomic measurements, and exposome monitoring data from the first trimester of pregnancy, along with spatial analysis of naturally shed teeth for prenatal metal concentrations; and (3) extending follow-up to identify childhood exposures to contaminants (through biomarkers and personal monitors); the home environment (e.g., physical activity and sleep patterns, food environment, green, blue and white space, and media usage); and medical exposures (e.g., prescription and non-prescription medications and surgical interventions) that relate to fetal and childhood growth, obesity at age 3 years, respiratory infection and asthma by age 5 years, and pulmonary function data at age 7.5 years. Additionally, novel statistical approaches will be used to determine the role of the intestinal and salivary microbiome as mediators of these effects. The collective expertise, methodologies, data, samples and preliminary results from this study will contribute to the planning of the broader ECHO Pediatric Cohorts initiative in order to advance our understanding of the environmental factors early in life that drive childhood and lifelong health.

项目摘要/摘要：我们对广泛存在的健康影响的认识存在重大差距

项目成果

Health Behavior Changes during the COVID-19 Pandemic: A Longitudinal Analysis among Children.

• DOI: 10.3390/ijerph19159220
• 发表时间: 2022-07-28
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Bekelman, Traci A.;Dong, Yanan;Elliott, Amy J.;Ferrara, Assiamira;Friesen, Kaylyn;Galarce, Maren;Gilbert-Diamond, Diane;Glueck, Deborah H.;Hedderson, Monique M.;Hockett, Christine W.;Karagas, Margaret R.;Knapp, Emily A.;Lucchini, Maristella;McDonald, Julia C.;Sauder, Katherine A.;Dabelea, Dana
• 通讯作者: Dabelea, Dana

Trends in Screen Time Use Among Children During the COVID-19 Pandemic, July 2019 Through August 2021.

• DOI: 10.1001/jamanetworkopen.2022.56157
• 发表时间: 2023-02-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Hedderson, Monique M.;Bekelman, Traci A.;Li, Mingyi;Knapp, Emily A.;Palmore, Meredith;Dong, Yanan;Elliott, Amy J.;Friedman, Chloe;Galarce, Maren;Gilbert-Diamond, Diane;Glueck, Deborah;Hockett, Christine W.;Lucchini, Maristella;Mcdonald, Julia;Sauder, Katherine;Zhu, Yeyi;Karagas, Margaret R.;Dabelea, Dana;Ferrara, Assiamira
• 通讯作者: Ferrara, Assiamira

Bronchiolitis hospitalizations in rural New England: clues to disease prevention.

• DOI: 10.1177/20499361221099447
• 发表时间: 2022-01
• 期刊: THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE
• 影响因子: 5.7
• 作者: Wright, Peter F.;Hoen, Anne G.;Jarvis, J. Dean;Zens, Michael S.;Dade, Erika F.;Karagas, Margaret R.;Taube, Juliana;Brickley, Elizabeth B.
• 通讯作者: Brickley, Elizabeth B.

Children's Particulate Matter Exposure Characterization as Part of the New Hampshire Birth Cohort Study.

• DOI: 10.3390/ijerph182212109
• 发表时间: 2021-11-18
• 期刊: International journal of environmental research and public health
• 作者: Thornburg J;Halchenko Y;McCombs M;Siripanichgon N;Dowell E;Cho SH;Egner J;Sayarath V;Karagas MR
• 通讯作者: Karagas MR