A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort Study

一项关于影响美国农村儿童终身健康的生命形成早期关键环境暴露的前瞻性研究：新罕布什尔州出生队列研究

• 批准号: 10204645
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 32.19万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10204645
• 关键词: 3 year old; 5 year old; Address; Affect; Age; Air; Air Pollutants; Air Pollution; Archives; Area; Asthma; Award; Behavior; Behavioral; Biological; Biological Markers; Birth; Blood; Blood specimen; COVID-19; COVID-19 pandemic; Cells; Cessation of life; Chemicals; Child; Child Development; Child Health; Childhood; Clinical; Cohort Studies; Colorado; Community Health; Country; Data; Diagnosis; Diet; Disinfectants; Disinfection; Economics; Enrollment; Ensure; Environmental Exposure; Environmental Risk Factor; Ethnic Origin; Ethnic group; Exposure to; Family; Feces; First Pregnancy Trimester; Food; Food Packaging; Future; Geographic Locations; Gestational Age; Growth; Hair; Hand; Health; Home environment; Household Air Pollution; Human Milk; Infant; Intervention; Interview; Intestines; Knowledge; Laboratories; Life; Life Style; Location; Measurement; Measures; Meconium; Mediator of activation protein; Medical; Medical Records; Metals; Methodology; Methods; Mission; Monitor; National Institute of Environmental Health Sciences; Natural experiment; New Hampshire; Obesity; Operative Surgical Procedures; Outcome; Parents; Participant; Pediatric cohort; Perception; Persons; Pharmaceutical Preparations; Phase; Physical activity; Placenta; Play; Poison; Policies; Population; Pregnancy; Prospective Studies; Psychosocial Stress; Questionnaires; Race; Research; Respiratory Signs and Symptoms; Respiratory Tract Infections; Restaurants; Role; Rural; Salivary; Sampling; Schools; Science; Shapes; Shock; Silicones; Site; Sleep; Socioeconomic Status; Stress; Structure of nail of toe; Surface; Testing; Time; Tooth structure; Travel; Umbilical Cord Blood; Universities; Urine; Viral; Water; Wheezing; Wood stove; Work; behavior change; climate change; cohort; coronavirus disease; design; drinking; early life exposure; ethnic diversity; experience; fetal; follow-up; food environment; food insecurity; healthy lifestyle; high risk; interest; metabolomics; microbiome; novel; obesity in children; obesity risk; pandemic disease; personal care products; postnatal; prenatal; prevent; programs; psychosocial; pulmonary function; racial and ethnic; respiratory; rural area; sample collection; sleep pattern; sociodemographic group; transmission process; tv watching; urinary

Project Summary/Abstract: Major gaps exist in our knowledge of the health impacts of widespread and dramatically expanding exposures among children in the US. Children from rural regions are particularly understudied, but may experience higher exposures to contaminants by drinking unregulated water; from household air pollution from wood stoves; and consequent to their rural and changing landscape (e.g., from climate change). As part of this ECHO Pediatric Cohorts application, we propose to take advantage of the NIEHS/EPA supported New Hampshire Birth Cohort Study (NHBCS): a rural, ongoing pregnancy cohort that has accrued over 1,500 maternal-infant dyads. By the beginning of the UH3 phase of this application, the anticipated cohort size will be 2,000, and as part of this ECHO Pediatric Cohorts application, accrual will be extended to 3,000 maternal-infant pairs. Clinical outcomes are being ascertained from interval interviews, questionnaires, medical records, in-person assessments and laboratory tests. The study has archived environmental (tap water and indoor air) and biological samples during pregnancy (maternal blood, urine and hair), as well as biological samples acquired at birth (infant cord blood, placenta and meconium) and during childhood (urine, blood, buccal cells, breast milk, toenails and stool). The ability to utilize these samples for a wide range of downstream analyses has been demonstrated. For the current application, emerging hypotheses of concern will be addressed by: (1) leveragingthe extant NHBCS to perform targeted and unsupervised metabolomic analyses of 1,000 cord blood samples and 250 paired maternal gestational blood samples, and assess associations with exposures, early growth, and the infant microbiome; (2) expandingdata acquisition, sample collection and participant accrual to more precisely characterize exposures and timing of early life exposures by obtaining urinary metal metabolomic measurements, and exposome monitoring data from the first trimester of pregnancy, along with spatial analysis of naturally shed teeth for prenatal metal concentrations; and (3) extending follow-up to identify childhood exposures to contaminants (through biomarkers and personal monitors); the home environment (e.g., physical activity and sleep patterns, food environment, green, blue and white space, and media usage); and medical exposures (e.g., prescription and non-prescription medications and surgical interventions) that relate to fetal and childhood growth, obesity at age 3 years, respiratory infection and asthma by age 5 years, and pulmonary function data at age 7.5 years. Novel statistical approaches will be used to determine the role of the intestinal and salivary microbiome as mediators of these effects. The collective expertise, methodologies, data, samples and preliminary results from this study will contribute to the planning of the broader ECHO Pediatric Cohorts initiative in order to advance our understanding of the environmental factors early in life that drive childhood and lifelong health.

项目摘要/摘要：我们对广泛和广泛的健康影响的认识存在重大差距， 在美国儿童中的暴露量急剧增加。农村地区的儿童尤其 研究不足，但可能会经历更高的暴露于污染物饮用不受管制的水; 家庭空气污染的木材炉灶;和随之而来的农村和不断变化的景观（例如，从 气候变化）。作为ECHO儿科队列应用程序的一部分，我们建议利用 NIEHS/EPA支持的新罕布什尔州出生队列研究（NHBCS）：一项农村正在进行的妊娠队列研究， 已经累积了超过1,500对母婴。在本申请的UH 3阶段开始时， 预期队列规模为2,000人，作为ECHO儿科队列申请的一部分， 扩展到3,000对母婴。临床结果正在从间隔访谈中确定， 调查问卷、医疗记录、亲自评估和实验室检测。该研究已存档 怀孕期间的环境（自来水和室内空气）和生物样本（母体血液、尿液和 头发），以及出生时采集的生物样本（婴儿脐带血、胎盘和胎粪）和 儿童期（尿液、血液、口腔细胞、母乳、脚趾甲和粪便）。利用这些样本进行 广泛的下游分析已得到证实。对于当前的应用，新兴的假设 关注的问题将通过以下方式解决：（1）确保现有的NHBCS执行有针对性的和无人监督的 对1，000份脐带血样本和250份配对母体妊娠血液样本进行代谢组学分析，以及 评估与暴露、早期生长和婴儿微生物组的关联;（2）扩大数据采集， 样本收集和参与者累积，以更准确地描述早期生命的暴露和时间 通过获得尿金属代谢组学测量值和来自 妊娠前三个月，沿着自然脱落牙齿的空间分析，用于产前金属 浓度;（3）扩大后续行动，以确定儿童接触污染物（通过 生物标记和个人监测器）;家庭环境（例如，体力活动和睡眠模式，食物 环境，绿色、蓝色和白色空间，以及媒体使用）;以及医疗暴露（例如，处方和 非处方药物和手术干预），与胎儿和儿童生长，肥胖， 3岁时，5岁时的呼吸道感染和哮喘，以及7.5岁时的肺功能数据。 新的统计方法将用于确定肠道和唾液微生物组的作用， 这些影响的媒介。这些专家的集体专门知识、方法、数据、样本和初步结果， 这项研究将有助于更广泛的ECHO儿科队列计划的规划， 我们对生命早期环境因素的理解，这些因素推动了儿童和终身健康。