Epidemiology, Biomarkers and Exposure Assessment of Metals

流行病学、生物标志物和金属暴露评估

• 批准号: 8881880
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 0.12万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8881880
• 关键词: Adult; Affect; Arsenic; Bangladesh; Biological Markers; Blood Pressure; Blood Vessels; Body mass index; Cardiovascular Diseases; Characteristics; Child Development; Child health care; Clinical; Clip; Collaborations; Data; Data Analyses; Development; Diastolic blood pressure; Diet; Disease; Epidemiologic Studies; Epidemiology; Exposure to; Fetal Development; Fetus; Fostering; Functional disorder; GLUT4 gene; Gelatinase B; General Population; Genes; Genetic Polymorphism; Genetic Predisposition to Disease; Gestational Diabetes; Glucose; Glucose Transporter; Glucose tolerance test; Goals; Grant; Health; Home environment; Household; Hypertension; Individual; Infant; Inflammation; Inflammatory; Knowledge; Life; Low Birth Weight Infant; Measures; Mercury; Metal exposure; Metals; Methods; Molecular; Morbidity - disease rate; Mothers; New England; New Hampshire; Newborn Infant; Non-Insulin-Dependent Diabetes Mellitus; Nutritional status; Only Child; Outcome; Perinatal Exposure; Plasminogen Activator Inhibitor 1; Policies; Population; Positioning Attribute; Pre-Eclampsia; Predisposition; Pregnancy; Pregnant Women; Prospective Studies; Public Health; Research; Risk; Risk Factors; SLC2A1 gene; Serum; Source; Structure of nail of toe; Subgroup; Superfund; System; Testing; Time; Trace Elements; Umbilical Cord Blood; Urine; Vascular Endothelial Cell; Water; Woman; Work; abstracting; blood pressure regulation; cardiovascular disorder risk; cardiovascular risk factor; clinical effect; cohort; design; disorder risk; drinking water; early life exposure; environmental chemical; epidemiologic data; glucose metabolism; glycemic control; high risk; in utero; inflammatory marker; insight; mortality; novel; offspring; population based; programs; remediation; response; superfund site; vascular endothelial dysfunction; water sampling/testing

Project 4: Abstract Project 4, a biomedical project, is an integral component of the Dartmouth Superfund Research Program. Over the past 18 years, we designed and tested methods of measuring environmentally relevant levels of exposure to metals and applied novel biomarkers of exposure, susceptibility, and early response to large- scaled, population-based epidemiologic studies in the US. To date, we have tested over 8,000 households for arsenic (As), of which over 3,500 had private water systems. A GIS analysis of the data (performed in collaboration with the Trace Element Analysis Core) revealed distinct "clusters" of high household water As levels. Over the past five years, we successfully established a pregnancy cohort of women who use private wells in one of these cluster regions. Of the household tap water samples tested thus far, ~15% exceeded the maximum contaminant level for As established by the US EPA of 10 ¿g/L. Over the next five years, we will begin recruitment in another cluster region that is adjacent to planned and existing Superfund sites. While evidence suggests that As is related to adult onset diabetes and hypertension, its effects on these outcomes during pregnancy are uncertain. Thus, we will determine whether As influences glucose and blood pressure control during pregnancy and identify potential genetic susceptibility loci for these effects. Additionally, we will test pregnant women and newborns for markers of systemic inflammation and vascular endothelial dysfunction that have been previously found to relate to As exposure among adults in more highly exposed regions. Our hypothesis is that pregnancy and fetal development represent "windows" of susceptibility to the effects of As on cardiometabolic outcomes. To our knowledge, our study is one of the only molecular epidemiologic investigations of pregnancy and early life exposure to As in vulnerable subgroups of the general population of the US. Cardiovascular disease is the leading cause of morbidity and mortality worldwide, and the risk for this disease begins early in life. Thus, we are now positioned to capitalize upon our work in the previous grant period to fill critical gaps in our understanding of the lifelong health impacts of early life exposure to As, one of the leading environmental chemicals of concern.

项目4：摘要 项目4是一个生物医学项目，是达特茅斯超级基金研究计划的一个组成部分。 在过去的18年里，我们设计并测试了测量环境相关水平的方法， 暴露于金属和应用新的生物标志物的暴露，易感性，和早期反应， 在美国进行的大规模、基于人群的流行病学研究。到目前为止，我们已经测试了8,000多个家庭， 砷（As），其中3，500多人拥有私人供水系统。对数据的地理信息系统分析（在 与微量元素分析中心的合作）揭示了不同的高家庭水砷的“集群” 程度.在过去的五年里，我们成功地建立了一个怀孕的妇女谁使用私人队列， 威尔斯在这些集群区域之一。在迄今为止测试的家庭自来水样本中，约15%超过了 美国环保局规定的砷最大污染物水平为10 μ g/L。未来五年，我们将 开始在另一个邻近计划和现有超级基金地点的集群区域招募人员。而 有证据表明，As与成人发病的糖尿病和高血压有关，其对这些结果的影响 怀孕期间不确定。因此，我们将确定As是否影响血糖和血压 怀孕期间的控制并确定这些影响的潜在遗传易感性位点。此外，我们将 检测孕妇和新生儿全身炎症和血管内皮功能障碍的标志物 先前发现与暴露程度较高地区成人的砷暴露有关。我们 假设是妊娠和胎儿发育代表了对As影响敏感性的“窗口 心脏代谢结果。据我们所知，我们的研究是唯一的分子流行病学之一， 调查一般人群中易受伤害亚组的妊娠和早期生活暴露于As的情况， 美方心血管疾病是全球发病率和死亡率的主要原因， 疾病在生命早期开始。因此，我们现在可以利用我们在上一次赠款中的工作， 这一时期填补了我们对早期生活暴露于As的终身健康影响的理解的关键空白， 主要的环境化学品。