Epidemiology, Biomarkers and Exposure Assessment of Metals

流行病学、生物标志物和金属暴露评估

• 批准号: 8881880
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 0.12万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8881880
• 关键词: Adult; Affect; Arsenic; Bangladesh; Biological Markers; Blood Pressure; Blood Vessels; Body mass index; Cardiovascular Diseases; Characteristics; Child Development; Child health care; Clinical; Clip; Collaborations; Data; Data Analyses; Development; Diastolic blood pressure; Diet; Disease; Epidemiologic Studies; Epidemiology; Exposure to; Fetal Development; Fetus; Fostering; Functional disorder; GLUT4 gene; Gelatinase B; General Population; Genes; Genetic Polymorphism; Genetic Predisposition to Disease; Gestational Diabetes; Glucose; Glucose Transporter; Glucose tolerance test; Goals; Grant; Health; Home environment; Household; Hypertension; Individual; Infant; Inflammation; Inflammatory; Knowledge; Life; Low Birth Weight Infant; Measures; Mercury; Metal exposure; Metals; Methods; Molecular; Morbidity - disease rate; Mothers; New England; New Hampshire; Newborn Infant; Non-Insulin-Dependent Diabetes Mellitus; Nutritional status; Only Child; Outcome; Perinatal Exposure; Plasminogen Activator Inhibitor 1; Policies; Population; Positioning Attribute; Pre-Eclampsia; Predisposition; Pregnancy; Pregnant Women; Prospective Studies; Public Health; Research; Risk; Risk Factors; SLC2A1 gene; Serum; Source; Structure of nail of toe; Subgroup; Superfund; System; Testing; Time; Trace Elements; Umbilical Cord Blood; Urine; Vascular Endothelial Cell; Water; Woman; Work; abstracting; blood pressure regulation; cardiovascular disorder risk; cardiovascular risk factor; clinical effect; cohort; design; disorder risk; drinking water; early life exposure; environmental chemical; epidemiologic data; glucose metabolism; glycemic control; high risk; in utero; inflammatory marker; insight; mortality; novel; offspring; population based; programs; remediation; response; superfund site; vascular endothelial dysfunction; water sampling/testing

Project 4: Abstract Project 4, a biomedical project, is an integral component of the Dartmouth Superfund Research Program. Over the past 18 years, we designed and tested methods of measuring environmentally relevant levels of exposure to metals and applied novel biomarkers of exposure, susceptibility, and early response to large- scaled, population-based epidemiologic studies in the US. To date, we have tested over 8,000 households for arsenic (As), of which over 3,500 had private water systems. A GIS analysis of the data (performed in collaboration with the Trace Element Analysis Core) revealed distinct "clusters" of high household water As levels. Over the past five years, we successfully established a pregnancy cohort of women who use private wells in one of these cluster regions. Of the household tap water samples tested thus far, ~15% exceeded the maximum contaminant level for As established by the US EPA of 10 ¿g/L. Over the next five years, we will begin recruitment in another cluster region that is adjacent to planned and existing Superfund sites. While evidence suggests that As is related to adult onset diabetes and hypertension, its effects on these outcomes during pregnancy are uncertain. Thus, we will determine whether As influences glucose and blood pressure control during pregnancy and identify potential genetic susceptibility loci for these effects. Additionally, we will test pregnant women and newborns for markers of systemic inflammation and vascular endothelial dysfunction that have been previously found to relate to As exposure among adults in more highly exposed regions. Our hypothesis is that pregnancy and fetal development represent "windows" of susceptibility to the effects of As on cardiometabolic outcomes. To our knowledge, our study is one of the only molecular epidemiologic investigations of pregnancy and early life exposure to As in vulnerable subgroups of the general population of the US. Cardiovascular disease is the leading cause of morbidity and mortality worldwide, and the risk for this disease begins early in life. Thus, we are now positioned to capitalize upon our work in the previous grant period to fill critical gaps in our understanding of the lifelong health impacts of early life exposure to As, one of the leading environmental chemicals of concern.

项目4：摘要 项目4是一个生物医学项目，是达特茅斯超级基金研究计划的组成部分。 在过去的18年中，我们设计和测试了测量环境相关水平的方法 暴露于金属和应用的新型生物标志物的暴露，敏感性和对大型反应的早期反应 在美国，基于人群的流行病学研究。迄今为止，我们已经测试了8,000多个家庭 砷（AS），其中3500多个具有私人水系统。 GIS分析数据（在 与痕量元素分析核心的合作）揭示了高级水的独特“集群” 水平。在过去的五年中，我们成功建立了一群使用私人的妇女 这些集群区域之一的井。到目前为止测试的家庭自来水样品中，约有15％超过 美国EPA建立的最大污染物水平为10€g/l。在接下来的五年中，我们将 在另一个与计划和现有超级基金站点相邻的集群区域开始招聘。尽管 有证据表明，与成人发作糖尿病和高血压有关，其对这些结果的影响 怀孕期间不确定。那就是我们将确定AS是否影响葡萄糖和血压 怀孕期间的控制并确定这些作用的潜在遗传易感性位置。此外，我们会的 测试孕妇和新生儿的系统创新和血管内皮功能障碍的标记 以前已经发现，与更高度暴露区域的成年人之间的暴露有关。我们的 假设是怀孕和胎儿发育代表了对AS的影响的易感性的“窗口” 在心脏代谢结果上。据我们所知，我们的研究是唯一的分子流行病学之一 对怀孕和早期生命暴露的调查，如在一般人群中的脆弱亚组中 美国。心血管疾病是全球发病率和死亡率的主要原因，而这一风险 疾病从生命的早期开始。那就是我们现在可以利用上一笔赠款的工作 填补关键空白的时期，我们了解早期生活对终生健康影响的时期 引起关注的主要环境化学品。