MAGNETIC RESONANCE IMAGING OF PHOSPHORUS IN BONE MINERAL

骨矿物中磷的磁共振成像

• 批准号: 3431851
• 负责人: JEROME L ACKERMAN
• 金额: $ 4.55万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1991-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3431851
• 关键词: Paget's disease of breast; calcium phosphate; chickens; clinical biomedical equipment; cow; magnetic resonance imaging; musculoskeletal disorder diagnosis; noninvasive diagnosis; normal ossification; orthopedics; osteoporosis; phantom model; physiologic bone resorption; wound healing

Recent developments in our laboratory have suggested that it may be possible to produce magnetic resonance images of the mineral phase of bone in living animals and, with sufficient longer term engineering and scientific development, in humans. Such images would be chemically specific, in that the spatial distribution of particular calcium phosphate mineral phases could be determined. This could be highly significant for several areas of biomedical research involving mineralized tissue, including developmental biology (development of the skeleton), trauma (healing of fractures), orthopedic surgery (remodeling/turnover at implant sites, behavior of hydroxyapatite-based prostheses), metabolic disease (Paget's and osteoporosis, calcium deposits in atherosclerotic plaque and elsewhere), and possibly cancer (when rapid mineral turnover in primary bone tumors is involved). Presently, there is no way to perform a noninvasive chemical analysis of the mineral phase on a living organism; biopsy allows such analysis in principle, but cannot show the complete spatial distribution. In some of these areas, bone mineral chemistry has been extensively studied, in others it has not, perhaps in part because of the lack of a good noninvasive method. We propose to extend our preliminary micro-scale successes in imaging calcium phosphate mineral distribution to the scale of small-to-medium research animals and human limbs, while keeping the experimental conditions favorable for eventual in vivo studies. The methods include hybrid 2DFT/backprojection imaging techniques combined with modified cross-polarization and other methods of solid-state NMR spectroscopy. Some components of the apparatus, including specialized RF and gradient coils, will be constructed as part of the project.

我们实验室的最新发展表明，这可能是 可能产生骨骼矿物相的磁共振图像 在活的动物中，并具有足够的长期工程和 科学发展，在人类中。 这样的图像将是化学的 具体，特定的磷酸钙的空间分布 可以确定矿物相。 这可能非常重要 涉及矿化组织的生物医学研究的几个领域， 包括发育生物学（骨骼的发展），创伤 （骨折的愈合），骨科手术（植入物的重塑/周转 地点，基于羟基磷灰石的假体的行为），代谢疾病 （Paget和骨质疏松症，动脉粥样硬化斑块中的钙沉积物和 在其他地方），甚至可能是癌症 骨骼肿瘤涉及）。 目前，没有办法执行 生物上矿物阶段的无创化学分析； 活检原则上允许这种分析，但不能显示完整的 空间分布。 在其中一些领域，骨矿物化学具有 经过广泛的研究，在另一些研究中，也许部分是因为 缺乏良好的无创方法。 我们建议在成像方面扩展我们的初步微尺度成功 磷酸钙矿物质分布到小到中等的尺度 研究动物和人类四肢，同时保持实验 有利于最终体内研究的条件。 这些方法包括 混合2DFT/反向投影成像技术与修改 交叉极化和其他固态NMR光谱法的方法。 设备的某些组件，包括专业的RF和梯度 线圈将作为项目的一部分构建。