DNA data development for cancer cell lines and patients

癌细胞系和患者的 DNA 数据开发

• 批准号: 10926648
• 负责人: William Reinhold
• 金额: $ 9.32万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10926648
• 关键词: Adrenocortical carcinoma; Almanacs; Area; CCR; Cancer cell line; Cancerous; Cell Line; Cell Survival; Clustered Regularly Interspaced Short Palindromic Repeats; DNA; DNA Methylation; DNA Sequence Alteration; DNA copy number; Data; Databases; Development; Developmental Therapeutics Program; Disease; Encyclopedias; Extramural Activities; Future; General Hospitals; Genes; Genetic; Genetic Transcription; Genomics; Goals; Knock-out; Malignant Neoplasms; Manuscripts; Massachusetts; Methylation; MicroRNAs; Molecular; Mutation; National Cancer Institute; National Cancer Program; Oncologist; Output; Patients; Pattern; Pharmaceutical Preparations; Pharmacology; Phenotype; Proteins; Publications; Publishing; Reporting; Sampling; Site; Source; Standardization; The Cancer Genome Atlas; Tissues; Transcript; Work; bioinformatics resource; drug sensitivity; genetic variant; interest; multiple data sources; neuroendocrine cancer; pharmacologic; response; small cell lung carcinoma; tool development; treatment response; web app; whole genome

This project is particularly informative in the area of DNA copy number, methylation and mutation, including gene and whole genome data for some 1,600 cell lines and 186 patients. The standardization and presentation of the data in the form of a web-application makes it accessible for non-bioinformaticians. The cell line work was done prior to the patient and thus is further developed. The patient data currently resides on an internal site. The database allows multiple forms of comparisons to phenotypic, molecular, or pharmacological patterns. Data is being provided to the user as response to queries or in toto. The cell line data is accessible through our CellMiner (for the NCI-60) or CellMinerCDB web-based applications. The project is meant to facilitate additional scientific analysis, tool development, and manuscript publication.

该项目在DNA拷贝数、甲基化和突变领域提供了特别丰富的信息，包括约1，600个细胞系和186名患者的基因和全基因组数据。以网络应用程序的形式对数据进行标准化和展示，使非生物信息学家可以访问。细胞系工作在患者之前完成，因此进一步开发。患者数据目前位于内部网站。该数据库允许多种形式的比较表型，分子或药理学模式。数据作为对查询的响应或全部提供给用户。细胞系数据可通过我们的CellMiner（用于NCI-60）或CellMinerCDB基于网络的应用程序访问。该项目旨在促进更多的科学分析，工具开发和手稿出版。

项目成果

R-Loop-Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin.

• DOI: 10.1158/1541-7786.mcr-20-0833
• 发表时间: 2021-08
• 期刊: Molecular cancer research : MCR
• 作者: Safari M;Litman T;Robey RW;Aguilera A;Chakraborty AR;Reinhold WC;Basseville A;Petrukhin L;Scotto L;O'Connor OA;Pommier Y;Fojo AT;Bates SE
• 通讯作者: Bates SE

Association of expression of epigenetic molecular factors with DNA methylation and sensitivity to chemotherapeutic agents in cancer cell lines.

• DOI: 10.1186/s13148-021-01026-4
• 发表时间: 2021-03-06
• 期刊: Clinical epigenetics
• 影响因子: 5.7
• 作者: Vural S;Palmisano A;Reinhold WC;Pommier Y;Teicher BA;Krushkal J
• 通讯作者: Krushkal J