Genomics and Bioinformatics Group web site development and maintenance.

基因组学和生物信息学组网站开发和维护。

• 批准号: 9154337
• 负责人: William Reinhold
• 金额: $ 23.25万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9154337
• 关键词: Binding; Bioinformatics; Biometry; Cancer Patient; Cancerous; Cell Line; Chemicals; Clinical Trials; Computer software; Country; DNA; DNA copy number; Data; Data Set; Databases; Development; Developmental Therapeutics Program; Extramural Activities; Generations; Genes; Genomics; Goals; Imagery; Individual; Internet; Laboratories; Lead; Location; Maintenance; Mammalian Cell; Maps; Metadata; Mining; Molecular; Molecular Biology; Online Systems; Output; Pharmaceutical Preparations; Pharmacogenomics; Pharmacology; Research; Resources; Scientist; Series; Site; System; Time; anticancer activity; comparative genomic hybridization; computer science; design; drug discovery; exome sequencing; genetic variant; molecular scale; quality assurance; repository; therapy outcome; tool; web site

We continueWe have successfully maintained and expanded our Discover web-based tools, with emphasis on CellMiner. Our CellMiner "NCI-60 Analysis Tools" section is providing a significant resource for pharmacogenomic integration, research, and discovery. It is currently the host for five tools, all of which are designed to reduce the time required by the scientist to integrate molecular and pharmacological data. Within the last year, four substaintial upgrades have been made, i) "Gene DNA copy number" signatures, ii) "Genetic variant summation" signatures, iii)"Graphical output for DNA: Exome sequencing", and iv) "Genetic variant versus drug visualization". Two new databases for the NCI-60 have been introduced, for DNA copy number from array comparative genomic hybridization hybridization, and exome sequencing of all genes. The CellMiner data and tools are creating major opportunities for progress in rational drug discovery, application, and individualization of therapy for cancer patients. As molecular alterations of many types can contribute to the outcome of therapy, the Genomic and Bioinformatics Group (GBG) manages and integrate molecular and pharmacological data in such a way that enhances understanding, and facilitates the generation of testable hypotheses in the context of pharmacology. The GBG thus provides access to high throughput data, in addition to providing software resources that facilitate the understanding, mining and exploitation of these data. Using our expertise in molecular biology, molecular pharmacology, biostatistics, bioinformatics, and computer science, we continue to generated public databases, and software to query and mine those data. The drug database is continuously expanded by the DTP, including new drugs entering clinical trials. The NCI-60 is by far the most comprehensively profiled panel of mammalian cells anywhere. Currently our Discover and CellMiner sites have thousands of individual users from 73 countries per month. It has in the past and currently continues to lead to translational discoveries.

我们继续我们已经成功地维护和扩展了我们的发现基于网络的工具，重点是CellMiner。我们的CellMiner“NCI-60分析工具”部分为药物基因组学整合、研究和发现提供了重要的资源。它目前是五个工具的主机，所有这些工具都旨在减少科学家整合分子和药理学数据所需的时间。在过去的一年中，已经进行了四次实质性升级，i）“基因DNA拷贝数”签名，ii）“遗传变异总和”签名，iii）“DNA的图形输出：外显子组测序”，以及iv）“遗传变异与药物可视化”。NCI-60的两个新数据库已经引入，用于阵列比较基因组杂交杂交的DNA拷贝数和所有基因的外显子组测序。CellMiner的数据和工具正在为癌症患者的合理药物发现、应用和个性化治疗创造重大机遇。由于许多类型的分子改变可以有助于治疗的结果，基因组和生物信息学组（GBG）管理和整合分子和药理学数据，以增强理解，并促进药理学背景下可验证假设的生成。因此，GBG除了提供有助于理解、挖掘和利用这些数据的软件资源外，还提供了对高吞吐量数据的访问。利用我们在分子生物学、分子药理学、生物统计学、生物信息学和计算机科学方面的专业知识，我们继续生成公共数据库和软件来查询和挖掘这些数据。DTP不断扩大药物数据库，包括进入临床试验的新药。NCI-60是迄今为止最全面的哺乳动物细胞图谱。目前，我们的Discover和CellMiner网站每月有来自73个国家的数千名个人用户。它在过去和现在继续导致翻译发现。