Elastin and Elastic Fibers

弹性蛋白和弹性纤维

• 批准号: 7743887
• 负责人: Richard A Pierce
• 金额: $ 2.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7743887
• 关键词: Aging; Aneurysm; Atherosclerosis; Award; Biocompatible Materials; Biological Assay; Biology; Bladder; Blood Vessels; Cells; Collaborations; Data; Dermis; Development; Discipline; Disease; Elastic Fiber; Elastic Tissue; Elastin; Exposure to; Homeostasis; Hypertension; In Vitro; Investigation; Lead; Light; Lung; Lung diseases; Mechanics; Modeling; Organogenesis; Participant; Pathology; Play; Prize; Property; Protein-Lysine 6-Oxidase; Proteins; Proteoglycan; Pulmonary Fibrosis; Pulmonary Hypertension; Recording of previous events; Regenerative Medicine; Research; Research Personnel; Resolution; Role; Skin; Structure; Sunlight; Time; Tissue Engineering; Tissues; Transgenic Organisms; Vertebrates; Wound Healing; abstracting; angiogenesis; fibrillin; fibulin; human disease; in vivo; insight; interest; knockout animal; latent TGF-beta binding protein; macromolecule; meetings; novel; posters; repaired; success; symposium

DESCRIPTION (provided by applicant): The Elastin and Elastic Fibers GRC originated in 1979 and has a distinguished history as the leading forum for the development of new ideas on the mechanism of elastic fiber assembly and role that elastic fibers play in tissue homeostasis and disease. The Conference is unique in the depth of its coverage of elastin biology, spanning from detailed, high-resolution structural studies of elastin and fibrillin, to in vitro assembly assays, to functional in vivo research with transgenic and knockout animals, to human disease, and finally to biomaterials and therapies. Over the past decade, the breadth of the Conference has also exploded with the identification and study of numerous elastic fiber-associated proteins, such as the fibulins, latent TGF-beta binding proteins, emilins, proteoglycans and lysyl oxidases. Research on these proteins has emphasized the complexity of the elastic fiber and highlighted the need for new collaborative studies between the biochemists, cell biologists and clinicians in the field. The 2009 Conference will focus on the most recent, exciting developments in the field from the past two years and stimulate discussion among the participants from diverse disciplines and backgrounds. Traditional sessions on elastin and fibrillin structure and assembly, and on tissue engineering of elastogenic materials will be included, however, new to the 2009 Conference will be the incorporation of this research into distinct sessions that revolve around specific tissue damage and repair that are critically dependent on elastin for structure and function, in the dermis, lung destruction and organogenesis, and angiogenesis. Also new to the 2009 Conference, will be a session on the interplay of tissue engineering and regenerative medicine applications of more sophisticated models that elucidate the interplay of elastin-associated macromolecules with an increasing interest in actively intervening in elastic tissue repair. In each morning session, time will be allocated to highlight 3 posters so as to emphasize the exciting research presented by our young researchers at the two poster sessions. To further encourage these young people, 3 poster prizes will be awarded at the final session. Overall, the GRC format differs from almost all other scientific meetings in that it provides an extensive opportunity for open, free and informal discussion. The success of each Conference is attributable to the participation of leaders in the field, new ideas and insight from young investigators, the presentation of unpublished data, engaging formal and informal discussions, and limited size and geographical isolation. In light of the success of past Elastin and Elastic Fiber GRCs, there is no question that the research presented and the discussions that will ensue at the 2009 Conference will lead to new and productive collaborations that will advance the field and uncover novel avenues of elastic fiber investigation. (End of Abstract)

描述（由申请人提供）： 弹性蛋白和弹性纤维 GRC 起源于 1979 年，作为发展弹性纤维组装机制以及弹性纤维在组织稳态和疾病中的作用的新思想的领先论坛，有着悠久的历史。此次会议在弹性蛋白生物学的深度报道方面是独一无二的，涵盖了从弹性蛋白和原纤维蛋白的详细、高分辨率结构研究，到体外组装测定，到转基因和基因敲除动物的功能性体内研究，到人类疾病，最后到生物材料和疗法。在过去的十年中，随着对许多弹性纤维相关蛋白的鉴定和研究，例如纤维蛋白、潜在的 TGF-β 结合蛋白、emilins、蛋白聚糖和赖氨酰氧化酶，会议的广度也呈爆炸式增长。对这些蛋白质的研究强调了弹性纤维的复杂性，并强调了该领域生物化学家、细胞生物学家和临床医生之间进行新的合作研究的必要性。 2009年会议将重点关注过去两年该领域令人兴奋的最新发展，并激发来自不同学科和背景的参与者之间的讨论。将包括关于弹性蛋白和原纤维蛋白结构和组装以及弹性材料的组织工程的传统会议，然而，2009年会议的新内容将是将这项研究纳入不同的会议，这些会议围绕特定的组织损伤和修复，这些组织的结构和功能严重依赖于弹性蛋白，在真皮中，肺破坏和器官发生以及血管发生。 2009 年会议的另一个新内容是关于组织工程和再生医学应用更复杂模型的相互作用的会议，这些模型阐明了弹性蛋白相关大分子的相互作用，以及人们对积极干预弹性组织修复的兴趣日益浓厚。在每天上午的会议上，我们将分配时间突出显示 3 张海报，以强调我们的年轻研究人员在两次海报会议上展示的令人兴奋的研究。为了进一步鼓励这些年轻人，决赛将颁发3名海报奖。 总体而言，GRC 形式与几乎所有其他科学会议的不同之处在于，它为公开、自由和非正式的讨论提供了广泛的机会。每次会议的成功都归功于该领域领导者的参与、年轻研究人员的新想法和见解、未发表数据的展示、正式和非正式的讨论以及有限的规模和地理隔离。鉴于过去弹性蛋白和弹性纤维 GRC 的成功，毫无疑问，2009 年会议上提出的研究和随后的讨论将带来新的、富有成效的合作，从而推动该领域的发展并揭示弹性纤维研究的新途径。 （摘要完）