Elastin and Elastic Fibers

弹性蛋白和弹性纤维

• 批准号: 7743887
• 负责人: Richard A Pierce
• 金额: $ 2.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7743887
• 关键词: Aging; Aneurysm; Atherosclerosis; Award; Biocompatible Materials; Biological Assay; Biology; Bladder; Blood Vessels; Cells; Collaborations; Data; Dermis; Development; Discipline; Disease; Elastic Fiber; Elastic Tissue; Elastin; Exposure to; Homeostasis; Hypertension; In Vitro; Investigation; Lead; Light; Lung; Lung diseases; Mechanics; Modeling; Organogenesis; Participant; Pathology; Play; Prize; Property; Protein-Lysine 6-Oxidase; Proteins; Proteoglycan; Pulmonary Fibrosis; Pulmonary Hypertension; Recording of previous events; Regenerative Medicine; Research; Research Personnel; Resolution; Role; Skin; Structure; Sunlight; Time; Tissue Engineering; Tissues; Transgenic Organisms; Vertebrates; Wound Healing; abstracting; angiogenesis; fibrillin; fibulin; human disease; in vivo; insight; interest; knockout animal; latent TGF-beta binding protein; macromolecule; meetings; novel; posters; repaired; success; symposium

DESCRIPTION (provided by applicant): The Elastin and Elastic Fibers GRC originated in 1979 and has a distinguished history as the leading forum for the development of new ideas on the mechanism of elastic fiber assembly and role that elastic fibers play in tissue homeostasis and disease. The Conference is unique in the depth of its coverage of elastin biology, spanning from detailed, high-resolution structural studies of elastin and fibrillin, to in vitro assembly assays, to functional in vivo research with transgenic and knockout animals, to human disease, and finally to biomaterials and therapies. Over the past decade, the breadth of the Conference has also exploded with the identification and study of numerous elastic fiber-associated proteins, such as the fibulins, latent TGF-beta binding proteins, emilins, proteoglycans and lysyl oxidases. Research on these proteins has emphasized the complexity of the elastic fiber and highlighted the need for new collaborative studies between the biochemists, cell biologists and clinicians in the field. The 2009 Conference will focus on the most recent, exciting developments in the field from the past two years and stimulate discussion among the participants from diverse disciplines and backgrounds. Traditional sessions on elastin and fibrillin structure and assembly, and on tissue engineering of elastogenic materials will be included, however, new to the 2009 Conference will be the incorporation of this research into distinct sessions that revolve around specific tissue damage and repair that are critically dependent on elastin for structure and function, in the dermis, lung destruction and organogenesis, and angiogenesis. Also new to the 2009 Conference, will be a session on the interplay of tissue engineering and regenerative medicine applications of more sophisticated models that elucidate the interplay of elastin-associated macromolecules with an increasing interest in actively intervening in elastic tissue repair. In each morning session, time will be allocated to highlight 3 posters so as to emphasize the exciting research presented by our young researchers at the two poster sessions. To further encourage these young people, 3 poster prizes will be awarded at the final session. Overall, the GRC format differs from almost all other scientific meetings in that it provides an extensive opportunity for open, free and informal discussion. The success of each Conference is attributable to the participation of leaders in the field, new ideas and insight from young investigators, the presentation of unpublished data, engaging formal and informal discussions, and limited size and geographical isolation. In light of the success of past Elastin and Elastic Fiber GRCs, there is no question that the research presented and the discussions that will ensue at the 2009 Conference will lead to new and productive collaborations that will advance the field and uncover novel avenues of elastic fiber investigation. (End of Abstract)

描述（由申请人提供）： 弹性蛋白和弹性纤维GRC起源于1979年，作为开发弹性纤维组装机制和弹性纤维在组织稳态和疾病中发挥作用的新思想的领先论坛，具有悠久的历史。该会议在其弹性蛋白生物学覆盖的深度方面是独一无二的，从弹性蛋白和弹性蛋白的详细，高分辨率结构研究，到体外组装试验，到转基因和基因敲除动物的体内功能研究，到人类疾病，最后到生物材料和疗法。在过去的十年中，会议的广度也随着许多弹性纤维相关蛋白质的鉴定和研究而激增，如纤蛋白、潜伏性TGF-β结合蛋白、emilins、蛋白聚糖和赖氨酰氧化酶。对这些蛋白质的研究强调了弹性纤维的复杂性，并强调了该领域生物化学家，细胞生物学家和临床医生之间新的合作研究的必要性。 2009年会议将重点关注过去两年来该领域最新的令人兴奋的发展，并激发来自不同学科和背景的与会者之间的讨论。传统的弹性蛋白和弹性蛋白的结构和组装，以及弹性材料的组织工程会议将被包括在内，然而，新的2009年会议将是这项研究纳入不同的会议，围绕特定的组织损伤和修复是关键依赖于弹性蛋白的结构和功能，在真皮，肺破坏和器官发生，血管生成。2009年会议的另一个新内容是关于组织工程和再生医学应用的相互作用的会议，这些更复杂的模型阐明了弹性蛋白相关大分子的相互作用，并对积极干预弹性组织修复产生了越来越大的兴趣。在每个上午的会议上，将分配时间突出3张海报，以强调我们的年轻研究人员在两个海报会议上提出的令人兴奋的研究。为了进一步鼓励这些年轻人，最后一节将颁发3个海报奖。 总的来说，GRC的形式与几乎所有其他科学会议不同，因为它提供了广泛的机会进行公开，自由和非正式的讨论。每次会议的成功都归功于该领域领导人的参与、年轻调查人员的新想法和见解、未发表数据的介绍、开展正式和非正式讨论以及规模有限和地理位置偏远。鉴于过去弹性蛋白和弹性纤维GRC的成功，毫无疑问，2009年会议上提出的研究和随后的讨论将导致新的富有成效的合作，这将推动该领域的发展，并揭示弹性纤维研究的新途径。 (End摘要）