Elastin and Elastic Fibers

描述(由申请人提供)： 弹性蛋白和弹性纤维GRC成立于1979年，作为开发弹性纤维组装机制和弹性纤维在组织动态平衡和疾病中所起作用的新思想的领先论坛，已经有了杰出的历史。这次会议对弹性蛋白生物学的深度报道是独一无二的，范围从弹性蛋白和纤维蛋白的详细、高分辨率结构研究，到体外组装分析，到转基因和基因敲除动物的体内功能研究，到人类疾病，最后到生物材料和治疗。在过去的十年里，会议的广度也随着对许多弹性纤维相关蛋白的识别和研究而爆炸式增长，例如纤维蛋白、潜在的转化生长因子-β结合蛋白、胞外多糖、蛋白多糖和赖氨酸氧化酶。对这些蛋白质的研究强调了弹性纤维的复杂性，并强调了该领域的生物化学家、细胞生物学家和临床医生之间进行新的合作研究的必要性。 2009年会议将侧重于过去两年来该领域最新、最令人振奋的事态发展，并鼓励来自不同学科和背景的与会者进行讨论。将包括关于弹性蛋白和纤维蛋白结构和组装以及弹性材料的组织工程的传统会议，然而，2009年会议的新内容将是将这项研究纳入不同的会议，这些会议围绕着在结构和功能上严重依赖弹性蛋白的特定组织损伤和修复，在真皮中，肺破坏和器官发生，以及血管生成。2009年大会的另一项新内容是关于组织工程和再生医学应用的相互作用的会议，更复杂的模型阐明了弹性蛋白相关大分子的相互作用，人们对积极干预弹性组织修复越来越感兴趣。在每天上午的会议中，将分配时间突出3张海报，以强调我们的年轻研究人员在两次海报会议上展示的令人兴奋的研究。为了进一步鼓励这些年轻人，将在最后一届会议上颁发3张海报奖。 总体而言，GRC的形式与几乎所有其他科学会议的不同之处在于，它为公开、自由和非正式的讨论提供了广泛的机会。每一次会议的成功都归功于实地领导人的参与、年轻研究人员的新想法和见解、提出未公布的数据、进行正式和非正式讨论以及规模有限和地理孤立。鉴于过去弹性蛋白和弹性纤维GRC的成功，毫无疑问，2009年会议上提出的研究和随后将进行的讨论将导致新的和富有成效的合作，这些合作将推动该领域的发展，并揭示弹性纤维研究的新途径。(摘要结束)

DESCRIPTION (provided by applicant): The Elastin and Elastic Fibers GRC originated in 1979 and has a distinguished history as the leading forum for the development of new ideas on the mechanism of elastic fiber assembly and role that elastic fibers play in tissue homeostasis and disease. The Conference is unique in the depth of its coverage of elastin biology, spanning from detailed, high-resolution structural studies of elastin and fibrillin, to in vitro assembly assays, to functional in vivo research with transgenic and knockout animals, to human disease, and finally to biomaterials and therapies. Over the past decade, the breadth of the Conference has also exploded with the identification and study of numerous elastic fiber-associated proteins, such as the fibulins, latent TGF-beta binding proteins, emilins, proteoglycans and lysyl oxidases. Research on these proteins has emphasized the complexity of the elastic fiber and highlighted the need for new collaborative studies between the biochemists, cell biologists and clinicians in the field. The 2009 Conference will focus on the most recent, exciting developments in the field from the past two years and stimulate discussion among the participants from diverse disciplines and backgrounds. Traditional sessions on elastin and fibrillin structure and assembly, and on tissue engineering of elastogenic materials will be included, however, new to the 2009 Conference will be the incorporation of this research into distinct sessions that revolve around specific tissue damage and repair that are critically dependent on elastin for structure and function, in the dermis, lung destruction and organogenesis, and angiogenesis. Also new to the 2009 Conference, will be a session on the interplay of tissue engineering and regenerative medicine applications of more sophisticated models that elucidate the interplay of elastin-associated macromolecules with an increasing interest in actively intervening in elastic tissue repair. In each morning session, time will be allocated to highlight 3 posters so as to emphasize the exciting research presented by our young researchers at the two poster sessions. To further encourage these young people, 3 poster prizes will be awarded at the final session. Overall, the GRC format differs from almost all other scientific meetings in that it provides an extensive opportunity for open, free and informal discussion. The success of each Conference is attributable to the participation of leaders in the field, new ideas and insight from young investigators, the presentation of unpublished data, engaging formal and informal discussions, and limited size and geographical isolation. In light of the success of past Elastin and Elastic Fiber GRCs, there is no question that the research presented and the discussions that will ensue at the 2009 Conference will lead to new and productive collaborations that will advance the field and uncover novel avenues of elastic fiber investigation. (End of Abstract)