MOLECULAR TARGETS IN BPD

BPD 中的分子靶标

• 批准号: 7716093
• 负责人: Richard A Pierce
• 金额: $ 2.26万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716093
• 关键词: Alveolar; Borderline Personality Disorder; Bronchopulmonary Dysplasia; Computer Retrieval of Information on Scientific Projects Database; Development; Elastin; Funding; Grant; Institution; Mechanical ventilation; Molecular Target; Myofibroblast; Papio; Research; Research Personnel; Resources; Retinoids; Signal Pathway; Source; Stretching; Supplementation; Testing; United States National Institutes of Health; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: Test the efficacy of retinoid supplementation in preventing or blunting the development of BPD in premature baboons. Specific Aim 2: Determine effects of current treatment therapies on alveolar myofibroblasts and alveolar elastin. Specific Aim 3: Characterize changes in stretch-activated signaling pathways due to mechanical ventilation.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体目标 1：测试类视黄醇补充剂在预防或减缓早产狒狒 BPD 发展方面的功效。 具体目标 2：确定当前治疗方法对肺泡肌成纤维细胞和肺泡弹性蛋白的影响。 具体目标 3：表征机械通气引起的牵拉激活信号通路的变化。