MOLECULAR TARGETS IN BPD

BPD 中的分子靶标

• 批准号: 7562476
• 负责人: Richard A Pierce
• 金额: $ 6万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562476
• 关键词: Alveolar; Borderline Personality Disorder; Bronchopulmonary Dysplasia; Computer Retrieval of Information on Scientific Projects Database; Development; Elastin; Funding; Grant; Institution; Mechanical ventilation; Molecular Target; Myofibroblast; Papio; Research; Research Personnel; Resources; Retinoids; Signal Pathway; Source; Stretching; Supplementation; Testing; United States National Institutes of Health; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1: Test the efficacy of retinoid supplementation in preventing or blunting the development of BPD in premature baboons. Specific Aim 2: Determine effects of current treatment therapies on alveolar myofibroblasts and alveolar elastin. Specific Aim 3: Characterize changes in stretch-activated signaling pathways due to mechanical ventilation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 具体目标1：测试补充类维生素类动物在预防或钝化BPD中的疗效。 具体目标2：确定当前治疗疗法对肺泡肌纤维细胞和肺泡弹性蛋白的影响。 特定目标3：表征由于机械通气引起的拉伸激活信号通路的变化。