2011 Elastin and Elastic Fibers GRS GRC

2011 弹性蛋白和弹性纤维 GRS GRC

• 批准号: 8205317
• 负责人: Richard A Pierce
• 金额: $ 3.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205317
• 关键词: Affect; Aging; American; Aneurysm; Atherosclerosis; Award; Biocompatible Materials; Biological Availability; Blood Vessels; Bronchopulmonary Dysplasia; Chronic Obstructive Airway Disease; Cutis Laxa; Deposition; Dermal; Development; Discipline; Disease; Elastic Fiber; Elastic Tissue; Elasticity; Elastin; Elastin Fiber; Fostering; Gender; Genetic; Growth Factor; Health; Health Care Costs; Hereditary Disease; Homeostasis; Human Genetics; Hypertension; In Vitro; Inherited; International; Learning; Lung; Lung diseases; Maine; Marfan Syndrome; Mentors; Musculoskeletal Diseases; National Heart, Lung, and Blood Institute; Nationalities; New England; Pathogenesis; Property; Pulmonary Hypertension; Regenerative Medicine; Research; Research Personnel; Research Support; Role; Scientist; Skin; Staging; Stroke; Systems Biology; Tissues; Travel; Tropoelastin; UV Radiation Exposure; Universities; Vascular Diseases; Vascular remodeling; Workplace; Wound Healing; base; calcification; career; fibulin; human disease; in vivo; insight; interdisciplinary approach; monomer; multidisciplinary; programs; protein function; protein structure; repaired; skin disorder; stem cell population; success; symposium; tissue regeneration; translational approach; ultraviolet damage

DESCRIPTION (provided by applicant): We propose to organize and support the 2011 Gordon Research Conference and Gordon Research Seminar on Elastin and Elastic Fibers to be held July 23-29, 2011 at the University of New England in Biddeford, Maine. This is the leading international research conference on elastin and elastic fibers, which are critical components of the vasculature, lung, skin and other elastic tissues. The conference will open with the latest findings on the protein structure of elastic fiber components including fibrilins, fibulins, LTBPs and tropoelastin monomers and their assembly in vitro and in vivo. Building on this structural basis, we will next learn the latest findings about unexpected roles of elastic fiber components in controlling the bioavailability and activation of growth factors critical for development, tissue homeostasis, wound healing, and tissue regeneration. Next, leading investigators will present the latest findings in human genetic diseases of elastic fiber components and how these offer insights into protein function and assembly. Sessions on acquired human diseases of elastic fibers follow, spanning the vasculature, lung, and skin, and offering new insights into the roles of elastin-producing stem cell populations critical for tissue homeostasis and repair. These translationally-oriented sessions focus on the roles of elastic fiber components in the pathogenesis of diseases including bronchopulmonary dysplasia, COPD, systemic and pulmonary hypertension, aneurysms, and acquired skin disorders including UV damage-induced loss of dermal elasticity and dermal calcification. The conference culminates in sessions on the development of elastin- based biomaterials, their structural and biophysical properties, and their applications to regenerative medicine. The specific objectives and anticipated impact of the combined GRS/GRC conference in 2011 are: 1) To gather diverse (gender, nationality, career stage and working environment) investigators from multiple disciplines together for a focused, comprehensive conference presenting the latest findings and ideas in elastin and elastic fiber research. 2) To foster collaborative opportunities between investigators which will inspire and facilitate multidisciplinary, systems biology and translational approaches to investigating protein structure and fibrillar assembly, the pathogenesis of acquired and genetic elastic fiber diseases in the vasculature, lung and skin, and progress in the development of elastin-based biomaterials and their application to regenerative medicine. 3) To encourage and mentor new trainees through the new Gordon Research Seminar toward career success in elastic fiber-related research and support them through travel and excellence awards.

描述(由申请人提供)： 我们建议组织和支持将于2011年7月23-29日在缅因州比德福德的新英格兰大学举行的2011年戈登研究会议和关于弹性蛋白和弹性纤维的戈登研究研讨会。这是关于弹性蛋白和弹性纤维的领先的国际研究会议，弹性蛋白和弹性纤维是血管、肺、皮肤和其他弹性组织的关键组成部分。会议将首先介绍弹性纤维成分的蛋白质结构的最新发现，包括纤维蛋白、纤维蛋白、LTBP和原弹性蛋白单体，以及它们在体外和体内的组装。在此结构基础上，我们接下来将学习有关弹性纤维成分在控制对发育、组织动态平衡、伤口愈合和组织再生至关重要的生长因子的生物利用度和激活方面的意外作用的最新发现。接下来，主要研究人员将介绍弹性纤维成分在人类遗传性疾病中的最新发现，以及这些发现如何为蛋白质功能和组装提供见解。接下来是关于后天人类弹性纤维疾病的会议，涉及血管系统、肺和皮肤，并提供了对产生弹性蛋白的干细胞群体对组织动态平衡和修复至关重要的作用的新见解。这些面向翻译的会议侧重于弹性纤维成分在各种疾病的发病机制中的作用，这些疾病包括支气管肺发育不良、COPD、全身和肺动脉高压、动脉瘤以及获得性皮肤病(包括紫外线损伤导致的真皮弹性丧失和真皮钙化)。会议的高潮是以弹性蛋白为基础的生物材料的开发，它们的结构和生物物理性质，以及它们在再生医学中的应用。2011年GRS/GRC合并会议的具体目标和预期影响是：1)将来自不同学科的不同(性别、国籍、职业阶段和工作环境)的研究人员聚集在一起，举行一次有重点的、全面的会议，展示弹性蛋白和弹性纤维研究的最新发现和想法。2)促进研究人员之间的合作机会，这将启发和促进多学科、系统生物学和翻译方法，以研究蛋白质结构和纤维组装、血管、肺和皮肤中获得性和遗传性弹性纤维疾病的发病机制，以及基于弹性蛋白的生物材料的开发及其在再生医学中的应用的进展。3)通过新的戈登研究研讨会鼓励和指导新学员，帮助他们在弹性纤维相关研究方面取得事业成功，并通过旅行和优秀奖项支持他们。