2011 Elastin and Elastic Fibers GRS GRC

2011 弹性蛋白和弹性纤维 GRS GRC

• 批准号: 8205317
• 负责人: Richard A Pierce
• 金额: $ 3.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8205317
• 关键词: Affect; Aging; American; Aneurysm; Atherosclerosis; Award; Biocompatible Materials; Biological Availability; Blood Vessels; Bronchopulmonary Dysplasia; Chronic Obstructive Airway Disease; Cutis Laxa; Deposition; Dermal; Development; Discipline; Disease; Elastic Fiber; Elastic Tissue; Elasticity; Elastin; Elastin Fiber; Fostering; Gender; Genetic; Growth Factor; Health; Health Care Costs; Hereditary Disease; Homeostasis; Human Genetics; Hypertension; In Vitro; Inherited; International; Learning; Lung; Lung diseases; Maine; Marfan Syndrome; Mentors; Musculoskeletal Diseases; National Heart, Lung, and Blood Institute; Nationalities; New England; Pathogenesis; Property; Pulmonary Hypertension; Regenerative Medicine; Research; Research Personnel; Research Support; Role; Scientist; Skin; Staging; Stroke; Systems Biology; Tissues; Travel; Tropoelastin; UV Radiation Exposure; Universities; Vascular Diseases; Vascular remodeling; Workplace; Wound Healing; base; calcification; career; fibulin; human disease; in vivo; insight; interdisciplinary approach; monomer; multidisciplinary; programs; protein function; protein structure; repaired; skin disorder; stem cell population; success; symposium; tissue regeneration; translational approach; ultraviolet damage

DESCRIPTION (provided by applicant): We propose to organize and support the 2011 Gordon Research Conference and Gordon Research Seminar on Elastin and Elastic Fibers to be held July 23-29, 2011 at the University of New England in Biddeford, Maine. This is the leading international research conference on elastin and elastic fibers, which are critical components of the vasculature, lung, skin and other elastic tissues. The conference will open with the latest findings on the protein structure of elastic fiber components including fibrilins, fibulins, LTBPs and tropoelastin monomers and their assembly in vitro and in vivo. Building on this structural basis, we will next learn the latest findings about unexpected roles of elastic fiber components in controlling the bioavailability and activation of growth factors critical for development, tissue homeostasis, wound healing, and tissue regeneration. Next, leading investigators will present the latest findings in human genetic diseases of elastic fiber components and how these offer insights into protein function and assembly. Sessions on acquired human diseases of elastic fibers follow, spanning the vasculature, lung, and skin, and offering new insights into the roles of elastin-producing stem cell populations critical for tissue homeostasis and repair. These translationally-oriented sessions focus on the roles of elastic fiber components in the pathogenesis of diseases including bronchopulmonary dysplasia, COPD, systemic and pulmonary hypertension, aneurysms, and acquired skin disorders including UV damage-induced loss of dermal elasticity and dermal calcification. The conference culminates in sessions on the development of elastin- based biomaterials, their structural and biophysical properties, and their applications to regenerative medicine. The specific objectives and anticipated impact of the combined GRS/GRC conference in 2011 are: 1) To gather diverse (gender, nationality, career stage and working environment) investigators from multiple disciplines together for a focused, comprehensive conference presenting the latest findings and ideas in elastin and elastic fiber research. 2) To foster collaborative opportunities between investigators which will inspire and facilitate multidisciplinary, systems biology and translational approaches to investigating protein structure and fibrillar assembly, the pathogenesis of acquired and genetic elastic fiber diseases in the vasculature, lung and skin, and progress in the development of elastin-based biomaterials and their application to regenerative medicine. 3) To encourage and mentor new trainees through the new Gordon Research Seminar toward career success in elastic fiber-related research and support them through travel and excellence awards.

描述（由申请人提供）： 我们建议在2011年7月23日至29日在缅因州比德福德的新英格兰大学组织和支持2011年戈登研究会议和戈登弹性纤维研究研讨会。这是关于弹性蛋白和弹性纤维的领先国际研究会议，它们是脉管系统，肺，皮肤和其他弹性组织的关键组成部分。该会议将以有关弹性纤维成分的蛋白质结构的最新发现，包括纤维蛋白，纤维蛋白，LTBPS和Tropoelastin单体及其体外和体内组装。在这种结构基础的基础上，我们接下来将了解有关弹性纤维成分在控制生长因子的生物利用度和激活中的意外作用的最新发现，这对于发育，组织稳态，伤口愈合和组织再生至关重要。接下来，领先的研究人员将介绍弹性纤维成分人类遗传疾病的最新发现，以及这些发现如何提供对蛋白质功能和组装的见解。随后进行弹性纤维的人类疾病的会话，跨越脉管系统，肺和皮肤，并提供新的见解，以了解产生弹性蛋白的干细胞群体对组织稳态和修复至关重要的作用。这些以翻译为导向的会话着重于弹性纤维成分在包括支气管肺发育异常，COPD，全身性和肺动脉瘤，动脉瘤以及所经过的皮肤疾病在内的疾病的发病机理中的作用，包括紫外线损害诱导的紫外线损害诱导的真皮弹性和皮肤弹性。会议最终会议涉及基于弹性蛋白的生物材料的发展，其结构和生物物理特性及其在再生医学上的应用。 2011年联合GRS/GRC会议的具体目标和预期影响是：1）从多个学科中收集多样化（性别，国籍，职业阶段和工作环境）的各种研究人员，共同进行了一个集中的，全面的会议，介绍了Elastin和Elastic Fiber Research中的最新发现和思想。 2）为了促进调查人员之间的合作机会，这些调查人员将激发和促进多学科，系统生物学和转化方法研究蛋白质结构和原纤维组装，在脉管系统，肺和皮肤中获得的获得和遗传弹性纤维疾病的发病机理，以及基于弹性蛋白基于生物体系的药物的进展。 3）通过新的戈登研究研讨会鼓励和指导新学员，以在与弹性纤维相关的研究中获得职业成功，并通过旅行和卓越奖励为他们提供支持。